Yahya Sohrabi,Holger Reinecke
Yahya Sohrabi
Unhealthy lifestyles and dietary habits often lead to diet-associated inflammatory diseases such as obesity and atherosclerosis. Recent studies have provided novel insight into the role of RIPK1 in inflammation and metabolism. RIPK1 silenci...
Zhongjie Fu,Lois E H Smith
Zhongjie Fu
Pathologic angiogenesis causes blindness in many eye diseases. Crespo-Garcia, Tsuruda, and Dejda et al. employed bioinformatics to characterize cell senescence as a primary factor in the common pathogenesis of retinopathies. They validated ...
Devanshi Mishra,Chinmoy Sankar Dey
Devanshi Mishra
Protein kinase C alpha (PKCα) is known to participate in various signaling pathways due to its ubiquitous and dynamic characteristics. Previous studies report that PKCα abrogates peripheral insulin resistance, and recent publications show...
Growth Hormone Modulation of Hepatic Epidermal Growth Factor Receptor Signaling [0.03%]
生长激素对肝脏表皮生长因子受体信号转导的调控
Lorena González,María E Díaz,Johanna G Miquet et al.
Lorena González et al.
Epidermal growth factor receptor (EGFR) signaling has a central role in the regenerative response of the liver upon injury and is involved in cellular transformation linked to chronic damage. Hepatic EGFR expression, trafficking, and signal...
Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective [0.03%]
中链脂肪酸的健康代谢作用：临床视角
Lili Huang,Lin Gao,Chen Chen
Lili Huang
Medium-chain fatty acids (MCFAs) serve not only as an energy source but also regulate glucose and lipid metabolism. The unique transport and rapid metabolism of MCFAs provide additional clinical benefits over other substrates such as long-c...
Miriam Butler,Laurens T van der Meer,Frank N van Leeuwen
Miriam Butler
Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment response in therapy resistant cancers as well as mitigate treatment-related toxicities by reducing the need for genotoxic agents. To meet their in...
Rebekah J Nicholson,Nirupama Ramkumar,Scott A Summers
Rebekah J Nicholson
Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular ...
Nektarios Barabutis
Nektarios Barabutis
Growth hormone releasing hormone (GHRH) is the integral regulator of the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis. It exerts mitogenic effects in a plethora of progressive cancers. Recent evidence suggests the emerging ...
Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion [0.03%]
乙酰辅酶A和代谢物通量调控白色脂肪组织的扩张
Jessica B Felix,Aaron R Cox,Sean M Hartig
Jessica B Felix
White adipose tissue (WAT) depends on coordinated regulation of transcriptional and metabolic pathways to respond to whole-body energy demands. We highlight metabolites that contribute to biosynthetic reactions for WAT expansion. Recent stu...
Shivani K Patel,Cindy S Ma,Spiros Fourlanos et al.
Shivani K Patel et al.
Up to 15% of individuals with a clinical phenotype of type 1 diabetes (T1D) do not have evidence of seropositivity for pancreatic islet autoantibodies. On this basis, they are classified as nonimmune or idiopathic, and remain an understudie...