Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease [0.03%]
代谢综合征与代谢失调相关脂肪肝病之间的联系
Soo Lim,Jin-Wook Kim,Giovanni Targher
Soo Lim
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition characterized by hepatic fat accumulation combined with underlying metabolic dysregulation. Having evolved from the previous term of nonalcoholic fatty live...
Multicolor fluorescence biosensors reveal a burning need for diversity in the single-cell metabolic landscape [0.03%]
多重荧光生物传感器揭示单细胞代谢图谱的多样性至关重要
Md Torikul Islam,William L Holland,Lisa A Lesniewski
Md Torikul Islam
Although cellular heterogeneity has been described for metabolic pathways, the upstream mechanisms, the downstream consequences, and the flexibility and transmission of these preferences to daughter cells remains largely unknown. Using live...
Abdulmaged M Traish
Abdulmaged M Traish
More men died of coronavirus disease 2019 (COVID-19) than women, suggesting estrogens may protect women. However, COVID-19 deaths among men and women were inconsistent among countries throughout the world. Genetics, epigenetics, and inborn ...
Brandon Podyma,Kavya Parekh,Ali D Güler et al.
Brandon Podyma et al.
Metabolic disorders result from dysregulation of central nervous system and peripheral metabolic energy homeostatic pathways. To maintain normal energy balance, neural circuits must integrate feedforward and feedback signals from the intern...
Barbara Cannon,Jan Nedergaard
Barbara Cannon
PERK protein, that is canonically associated with the response to endoplasmic reticulum stress, may be acquiring a new role as a regulator of the growth of mitochondrial cristae. This role is pertinent not only to the recruitment of brown a...
Of 'junk food' and 'brain food': how parental diet influences offspring neurobiology and behaviour [0.03%]
垃圾食品和脑力食物：父母饮食如何影响后代的神经生物学和行为
Carina Bodden,Anthony J Hannan,Amy C Reichelt
Carina Bodden
Unhealthy lifestyles and mental health problems are increasingly prevalent globally. Not only are 'junk food'-induced overweight and obesity risk factors for the development of brain disorders but they are also associated intergenerationall...
Why equalising HIIT and MICT is important: attention to methodological details [0.03%]
为什么使HIIT和MICT平等化很重要：方法细节需要注意
Leonardo Vidal Andreato,Alexandro Andrade,João Victor Esteves
Leonardo Vidal Andreato
Guillaume Mabilleau,Hélène Libouban,Valérie Geoffroy
Guillaume Mabilleau
McDonald and colleagues reported osteoclast-related dynamic mechanisms that lead, by fission, to osteomorphs; motile, fusion-competent cells capable of forming bone-resorbing osteoclasts. scRNA-seq analyses revealed that osteomorphs are tra...
Daniele Bellavia,Fabio Caradonna,Eufrosina Dimarco et al.
Daniele Bellavia et al.
The development of progressive osteopenia and osteoporosis (OP) is due to the imbalance between bone resorption and bone formation, determining a lower bone resistance, major risks of fractures, with consequent pain and functional limitatio...
Thomas Siff,Parash Parajuli,Mohammed S Razzaque et al.
Thomas Siff et al.
Muscle cachexia has a major detrimental impact on cancer patients, being responsible for 30% of all cancer deaths. It is characterized by a debilitating loss in muscle mass and function, which ultimately deteriorates patients' quality of li...