Gut and vaginal microbiomes on steroids: implications for women's health [0.03%]
类固醇下的肠道和阴道菌群及其对女性健康的影响
Madeline E Graham,William G Herbert,Stephanie D Song et al.
Madeline E Graham et al.
This review discusses the interactions of steroids with the gut and vaginal microbiomes within each life phase of adult women and the implications for women's health. Each phase of a woman's life is characterized by distinct hormonal states...
The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health [0.03%]
泛素-蛋白酶体系统与自噬作用：代谢健康的自我消化作用
Jia Liang Sun-Wang,Alex Yarritu-Gallego,Saška Ivanova et al.
Jia Liang Sun-Wang et al.
Type 2 diabetes mellitus (T2DM) is a global health challenge. Therefore, understanding the molecular mechanisms underlying the pathophysiology of T2DM is key to improving current therapies. Loss of protein homeostasis leads to the accumulat...
Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation [0.03%]
胰岛β细胞成熟及功能适应的转录机制
Matthew Wortham,Maike Sander
Matthew Wortham
Pancreatic β-cells secrete insulin commensurate to circulating nutrient levels to maintain normoglycemia. The ability of β-cells to couple insulin secretion to nutrient stimuli is acquired during a postnatal maturation process. In mature ...
John Henderson,Steven O&#x;Reilly
John Henderson
The metabolic shift that cancer cells undergo towards aerobic glycolysis was identified as a defining feature in tumours almost 100 years ago; however, it has only recently become apparent that similar metabolic reprogramming is a key featu...
Fructose-1,6-bisphosphate promotes PI3K and glycolysis in T cells? [0.03%]
果糖-1,6-二磷酸促进T细胞中PI3K和糖酵解？
Philippe Icard,Marco Alifano,Emmanuel Donnadieu et al.
Philippe Icard et al.
We propose that fructose-1,6-bisphosphate (F-1,6-BP) promotes a feedback loop between phosphofructokinase-1 (PFK1), phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), and PFK2/PFKFB3, which enhances aerobic glycolysis and sustains e...
Ferritinophagy and ferroptosis in the management of metabolic diseases [0.03%]
铁死亡和铁蛋白自噬在代谢性疾病管理中的作用
Amir Ajoolabady,Hamid Aslkhodapasandhokmabad,Peter Libby et al.
Amir Ajoolabady et al.
Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for huma...
Temporal single-cell regeneration studies: the greatest thing since sliced pancreas? [0.03%]
时间单细胞再生研究：自从切片胰腺以来最伟大的发现？
Juan Domínguez-Bendala,Mirza Muhammad Fahd Qadir,Ricardo Luis Pastori
Juan Domínguez-Bendala
The application of single-cell analytic techniques to the study of stem/progenitor cell niches supports the emerging view that pancreatic cell lineages are in a state of flux between differentiation stages. For all their value, however, suc...
Nikolai P Jaschke,Sophie Paehlig,Tilman D Rachner
Nikolai P Jaschke
Soluble mediators secreted by skeletal muscles (collectively referred to as myokines) exert systemic effects by signaling to distant organs. Rai et al. have now uncovered a muscle-to-central nervous system (CNS) signaling axis, which is eng...
Assessing the risk of having a child with classic 21-hydroxylase deficiency: a new paradigm [0.03%]
评估孩子患经典21-羟化酶缺乏症风险的新方法
Jacob Ilany,Ohad Cohen
Jacob Ilany
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a complicated condition genetically, clinically, and treatment wise. Genetically, there are numerus mutations with different effect on enzyme activity that make geneti...
Maceler Aldrovandi,Maria Fedorova,Marcus Conrad
Maceler Aldrovandi
Lipid peroxidation (LPO) is the molecular mechanism involved in oxidative damage of cellular membranes and the hallmark of a nonapoptotic form of cell death, known as ferroptosis. This iron-dependent cell death is an emerging strategy in ca...