Cynthia M Bulik,Ian M Carroll,Phil Mehler
Cynthia M Bulik
Anorexia nervosa (AN) is a serious and often fatal illness. Despite decades of research, investigators have failed to adequately advance our understanding of the biological aspects of AN that could inform the development of effective interv...
Daniel J Torres,Matthew W Pitts
Daniel J Torres
A new mechanism of leptin extravasation from the bloodstream into the brain may have been discovered. According to recent findings by Butiaeva et al., pericytes within the blood-brain barrier (BBB) express the leptin receptor and, upon acti...
Corticosteroid receptors as a model for the Hsp90•immunophilin-based transport machinery [0.03%]
基于Hsp90•免疫衍生物的运输装置的糖皮质激素受体模型研究进展
Gisela I Mazaira,Graciela Piwien Pilipuk,Mario D Galigniana
Gisela I Mazaira
Steroid receptors form soluble heterocomplexes with the 90-kDa heat-shock protein (Hsp90) and other chaperones and co-chaperones. The assembly and composition of the oligomer is influenced by the presence and nature of the bound steroid. Al...
Shirin Geravandi,Azam Mahmoudi-Aznaveh,Zahra Azizi et al.
Shirin Geravandi et al.
The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into...
Integrating metabolic reprogramming and metabolic imaging to predict breast cancer therapeutic responses [0.03%]
整合代谢重构和代谢影像以预测乳腺癌治疗反应
Yi Liu,Qian Zhou,Shaoli Song et al.
Yi Liu et al.
Metabolic reprogramming is not only an emerging hallmark of cancer, but also an essential regulator of cancer cell adaptation to the microenvironment. Metabolic imaging targeting metabolic signatures has been widely used for breast cancer d...
Niklas Joisten,Sebastian Gehlert,Philipp Zimmer
Niklas Joisten
High-intensity interval training (HIIT) is a common method to increase performance and promote health in elite sports, rehabilitation, and disease prevention. Flockhart et al. suggest a limit of HIIT above which detrimental effects on metab...
Julien Cassereau,Philippe Corcia,Pascal Reynier
Julien Cassereau
Mohassel et al. provide unprecedented dichotomy of consequences on sphingolipid biosynthesis between pathogenic variants in the SPTLC1 gene, responsible for either amyotrophic lateral sclerosis (ALS) or hereditary sensory and autonomic neur...
Roya Solhi,Majid Lotfinia,Roberto Gramignoli et al.
Roya Solhi et al.
Despite the crucial role of cell metabolism in biological processes, particularly cell division, metabolic aspects of liver regeneration are not well defined. Better understanding of the metabolic activity governing division of liver cells ...
Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis [0.03%]
重思琥珀酸：能量稳态中的代谢激素作用分子
Sonia Fernández-Veledo,Victòria Ceperuelo-Mallafré,Joan Vendrell
Sonia Fernández-Veledo
There has been an explosion of interest in the signaling capacity of energy metabolites. A prime example is the Krebs cycle substrate succinate, an archetypal respiratory substrate with functions beyond energy production as an intracellular...
Valentina Capelli,Carlos Diéguez,Jens Mittag et al.
Valentina Capelli et al.
In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH 'central' metabolic action, whic...