Alessio Molfino,Giovanni Imbimbo,Maurizio Muscaritoli
Alessio Molfino
Andrew J Monteith,Eric P Skaar
Andrew J Monteith
Nutrient transition metals are required cofactors for many proteins to perform functions necessary for life. As such, the concentration of nutrient metals is carefully maintained to retain critical biological processes while limiting toxici...
Terpenoid treatment in osteoporosis: this is where we have come in research [0.03%]
香萜素治疗骨质疏松症：研究进展及其作用机制
Daniele Bellavia,Fabio Caradonna,Eufrosina Dimarco et al.
Daniele Bellavia et al.
Lower bone resistance to load is due to the imbalance of bone homeostasis, where excessive bone resorption, compared with bone formation, determines a progressive osteopenia, leading to a high risk of fractures and consequent pain and funct...
Etherglycerophospholipids and ferroptosis: structure, regulation, and location [0.03%]
乙太甘油磷脂与铁死亡：结构、调节及定位
David Balgoma,Mikael Hedeland
David Balgoma
Two pioneering studies by Zou et al. and Cui et al. have reported that the synthesis of etherglycerophospholipids (etherPLs) sensitizes cells to ferroptosis. The location and regulation of etherPLs suggest that: (i) lipid peroxidation in th...
Kathryn B Smedlund,Edwin R Sanchez,Terry D Hinds Jr
Kathryn B Smedlund
The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis an...
Jekyll and Hyde: nuclear receptors ignite and extinguish hepatic oxidative milieu [0.03%]
杰克与海德：核受体点燃和熄灭肝脏氧化微环境
Anushna Sen,Sayeepriyadarshini Anakk
Anushna Sen
Nuclear receptors (NRs) are ligand-binding transcription factors that regulate gene networks and physiological responses. Often oxidative stress precedes the onset of liver diseases, and Nrf2 is a key regulator of antioxidant pathways. NRs ...
Genna E Moldovan,Lucio Miele,Asgerally T Fazleabas
Genna E Moldovan
The Notch signaling pathway is conserved among mammalian species and controls proliferation, differentiation, and cell death in many organs throughout the body including the reproductive tract. Notch signaling plays critical roles in the de...
Skylar R Batty,Paul R Langlais
Skylar R Batty
Microtubules (MT) have a role in the intracellular response to insulin stimulation and subsequent glucose transport by glucose transporter 4 (GLUT4), which resides in specialized storage vesicles that travel through the cell. Before GLUT4 i...
Salva R Yurista,Christopher T Nguyen,Anthony Rosenzweig et al.
Salva R Yurista et al.
Accumulating evidence suggests that the failing heart reverts energy metabolism toward increased utilization of ketone bodies. Despite many discrepancies in the literature, evidence from both bench and clinical research demonstrates benefic...
Takumi Satoh
Takumi Satoh
Drift of oxygen concentrations in the atmosphere was one of the main drivers of the evolution of vertebrates. The drop in oxygen concentrations at the Permian-Triassic (PT) boundary may have been the biggest challenge to vertebrates. This h...