Bijoya Basu,Mahim Jain,Atul R Chopra
Bijoya Basu
Hormones have traditionally been classified by their mode of biosynthetic origin. We postulate a mode of hormone biosynthesis that leads to a new subclass of protein hormones. Members of this class are derived from a cleavage event that als...
Sex differences in Alzheimer's disease: metabolic reprogramming and therapeutic intervention [0.03%]
阿尔茨海默病中的性别差异：代谢重编程及治疗干预
Lloyd A Demetrius,Anne Eckert,Amandine Grimm
Lloyd A Demetrius
Studies on the sporadic form of Alzheimer's disease (AD) have revealed three classes of risk factor: age, genetics, and sex. These risk factors point to a metabolic dysregulation as the origin of AD. Adaptive alterations in cerebral metabol...
Early adversity and insulin: neuroendocrine programming beyond glucocorticoids [0.03%]
早期逆境和胰岛素：超出糖皮质激素的神经内分泌编程
Aashita Batra,Maeson Latsko,Andre Krumel Portella et al.
Aashita Batra et al.
Exposure to direct or contextual adversities during early life programs the functioning of the brain and other biological systems, contributing to the development of physical as well as mental health issues in the long term. While the role ...
Gabriella Milan,Scilla Conci,Marta Sanna et al.
Gabriella Milan et al.
We describe adipose stromal/stem cells (ASCs) in the structural/functional context of the adipose tissue (AT) stem niche (adiponiche), including cell-cell interactions and the microenvironment, and emphasize findings obtained in humans and ...
Mechanisms of lipid metabolism in uterine receptivity and embryo development [0.03%]
脂质代谢在子宫容受性和胚胎发育中的机制
Qianhong Ye,Xiangzhou Zeng,Shuang Cai et al.
Qianhong Ye et al.
Metabolic regulation plays important roles in embryo development and uterine receptivity during early pregnancy, ultimately influencing pregnancy efficiency in mammals. The important roles of lipid metabolism during early pregnancy have not...
GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism [0.03%]
GDF15：一个新兴的免疫调节因子及其与铁代谢相关的COVID-19策略
Luc Rochette,Marianne Zeller,Yves Cottin et al.
Luc Rochette et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of respiratory and cardiovascular diseases, known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes the structural proteins spike (S), envelope (E),...
From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI [0.03%]
从苯二氮平类受体到脂肪酸及更多：重新审视ACBP / DBI的作用
Thierry Alquier,Catherine A Christian-Hinman,Julieta Alfonso et al.
Thierry Alquier et al.
Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABAA receptor, and was thus termed diazepam binding inhibitor (DBI). Shortly after, an ident...
Mansour Haidar,Melanie Loix,Jeroen F J Bogie et al.
Mansour Haidar et al.
Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions. In recent ye...
Susanne Keipert,Mario Ost
Susanne Keipert
Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) are established as stress-responsive cytokines that can modulate energy balance by increasing energy expenditure or suppressing food intake, respectively. Desp...
Vitamin D toxicity related to its physiological and unphysiological supply [0.03%]
与维生素D的生理性和非生理性供给相关的维生素D中毒问题
David R Fraser
David R Fraser
Vitamin D is defined as a nutrient despite its rare occurrence in food. Vitamin D status is determined mainly by solar UV light action in skin. However, the strategy to combat vitamin D deficiency has been to increase oral intake of vitamin...