Adipocyte extracellular vesicles: rescuers of cardiac mitochondrial stress [0.03%]
脂肪细胞胞外囊泡：心脏线粒体应激的救援者
Xavier Loyer,Chantal M Boulanger,Soazig Le Lay
Xavier Loyer
Nutrient excess induces mitochondrial dysfunction, which participates in obesity-related complications. Obesity also associates with high cardiac oxidative stress, which contributes to myocardial dysfunction. Crewe et al. recently evidenced...
Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline [0.03%]
痴呆和糖尿病视网膜病变的共同途径：了解与糖尿病相关认知能力下降的机制
Karis Little,María Llorián-Salvador,Sarah Scullion et al.
Karis Little et al.
Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are charact...
Hexokinase domain-containing protein-1 in metabolic diseases and beyond [0.03%]
含己糖激酶结构域蛋白-1在代谢性疾病及相关领域中的作用
Joseph L Zapater,Kristen R Lednovich,Md Wasim Khan et al.
Joseph L Zapater et al.
Glucose phosphorylation by hexokinases (HKs) traps glucose in cells and facilitates its usage in metabolic processes dependent on cellular needs. HK domain-containing protein-1 (HKDC1) is a recently discovered protein with wide expression c...
Stanley S Schwartz,Amy W Rachfal,Barbara E Corkey
Stanley S Schwartz
Current thresholds for diagnosing diabetes are outdated and do not represent advancements in disease understanding or ability to impact course. Today, evidence supports intervening earlier along the disease continuum to mitigate transition ...
Emerging roles of N-linked glycosylation in brain physiology and disorders [0.03%]
N-连接糖基化在脑生理和疾病中发挥的作用愈发凸显
Lindsey R Conroy,Tara R Hawkinson,Lyndsay E A Young et al.
Lindsey R Conroy et al.
N-linked glycosylation is a complex, co- and post-translational series of events that connects metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans multiple cellular compartments, and early N-linked glyc...
Matthew Beymer
Matthew Beymer
Stephanie Fulton,Léa Décarie-Spain,Xavier Fioramonti et al.
Stephanie Fulton et al.
The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral adipose accumulation. Resulting metabolic and vascular dys...
Cedric Zimmer,H Arthur Woods,Lynn B Martin
Cedric Zimmer
Information theory has been applied productively across biology, but it has been used minimally in endocrinology. Here, we advocate for the integration of information theory into stress endocrinology. Presently, the majority of models of st...
Tracy Ann Williams,Martin Reincke
Tracy Ann Williams
Primary aldosteronism (PA) can be sporadic or familial and classified into unilateral and bilateral forms. Sporadic PA predominates with excessive aldosterone production usually arising from a unilateral aldosterone-producing adenoma (APA) ...
Matthew Beymer
Matthew Beymer