Alexis M Ceasrine,Staci D Bilbo
Alexis M Ceasrine
Poor nutrition, lack of exercise, and genetic predisposition all contribute to the growing epidemic of obesity. Overweight/obesity create an environment of chronic inflammation that leads to negative physiological and neurological outcomes,...
Marta Bosch,Albert Pol
Marta Bosch
As major eukaryotic lipid storage organelles, lipid droplets (LDs) are metabolic hubs coordinating energy flux and building block distribution. Infectious pathogens often promote accumulation and physically interact with LDs. The most accep...
Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic-pituitary-ovarian axis [0.03%]
肥胖相关下丘脑-垂体-卵巢轴紊乱的下丘脑机制
Xiaolin Chen,Zhuoni Xiao,Yuli Cai et al.
Xiaolin Chen et al.
Ovulatory disorders are the most common clinical feature exhibited among obese women. Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone (GnRH) released from GnRH neurons located in the hypothalamus. ...
Hanhua Cheng,Rongjia Zhou
Hanhua Cheng
Over the past 440 years since the discovery of the medicinal value of swamp eels, much progress has been made in the study of their biology. The fish is emerging as an important model animal in sexual development, in addition to economic an...
Katia Monsorno,An Buckinx,Rosa C Paolicelli
Katia Monsorno
Microglia, the resident macrophages of the central nervous system (CNS), play important functions in the healthy and diseased brain. In the emerging field of immunometabolism, progress has been made in understanding how cellular metabolism ...
Bibek Gyanwali,Zi Xiang Lim,Janjira Soh et al.
Bibek Gyanwali et al.
Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These plei...
Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson's disease [0.03%]
近期研究的总结：帕金森病中的肠道α-突触核蛋白和菌群变化
Ehraz Anis,Aoji Xie,Lena Brundin et al.
Ehraz Anis et al.
Two hallmarks of Parkinson's disease (PD) are the widespread deposition of misfolded alpha-synuclein (αSyn) protein in the nervous system and loss of substantia nigra dopamine neurons. Recent research has suggested that αSyn aggregates in...
Stefan Bröer
Stefan Bröer
Amino acids modulate glucose homeostasis. Cytosolic levels of amino acids are regulated by amino acid transporters, modulating insulin release, protein synthesis, cell proliferation, cell fate, and metabolism. In β-cells, amino acid transp...
The changing clinical spectrum of endocrine adverse events in cancer immunotherapy [0.03%]
癌症免疫治疗的内分泌不良事件的临床谱变化
Sabrina Chiloiro,Antonio Bianchi,Antonella Giampietro et al.
Sabrina Chiloiro et al.
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of several malignancies, improving patient survival and quality of life. Endocrinopathies have emerged as a clinically significant group of immune-related adverse events ...
A two-front nutritional environment fuels colorectal cancer: perspectives for dietary intervention [0.03%]
双重营养环境促进结直肠癌的发展：饮食干预的视角
Elien Alderweireldt,Charlotte Grootaert,Olivier De Wever et al.
Elien Alderweireldt et al.
Colorectal cancer (CRC) develops and progresses in a nutritional environment comprising a continuously changing luminal cocktail of external dietary and microbial factors on the apical side, and a dynamic host-related pool of systemic facto...