Dietary and pharmacological energy restriction and exercise for healthspan extension [0.03%]
饮食限制、药物限制和运动对健康寿命的影响
Maria Lastra Cagigas,Isabella De Ciutiis,Andrius Masedunskas et al.
Maria Lastra Cagigas et al.
Extending healthspan - the years lived in optimal health - holds transformative potential to reduce chronic diseases and healthcare costs. Dietary restriction (DR), particularly when combined with nutrient-rich diets and exercise, is among ...
Shuqin Zeng,Shaopu Wang,Dezhi Mu
Shuqin Zeng
Establishment of the early-life gut microbiome, coinciding with the host development, predisposes to long-term disease risk if disrupted. Recently, Hill et al. precisely delineated a critical early-life window in humans and mice during whic...
Christian Dölle,Charalampos Tzoulis
Christian Dölle
Neurodegenerative diseases (NDDs) pose a significant and rapidly growing global health challenge, but there are no effective therapies to delay or halt progression. In recent years augmentation of nicotinamide adenine dinucleotide (NAD) has...
Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes [0.03%]
妊娠期糖尿病致2型糖尿病的遗传学及表观遗传学机制研究进展
Dewei Kong,Oliwia Kowalik,Emma Garratt et al.
Dewei Kong et al.
Gestational diabetes mellitus (GDM) is a common pregnancy complication and a risk factor for the subsequent development of type 2 diabetes (T2D) in mothers and of several metabolic diseases in offspring. However, the molecular underpinnings...
Promising results but caution needed in GLP-1RA large scale epidemiology [0.03%]
大型流行病学研究结果令人鼓舞但仍需谨慎评估(GLP-1RA)
Salil V Deo,Naveed A Sattar
Salil V Deo
Investigating the association between glucagon-like peptide 1 receptor agonists (GLP1-RAs) and incident disease across 175 health outcomes in US Veterans with diabetes, Xie et al. recently reported lower risk for cardiokidney disease and su...
Md Saidur Rahman,Yunjeong Park,Hossein Hosseinirad et al.
Md Saidur Rahman et al.
Endometriosis, characterized by uterine-like tissue growth outside the uterus, is a complex disorder with significant clinical implications. This review explores how body composition - both low body mass index (BMI) and obesity - modulates ...
Jie Cheng,Yifeng Xiao,Peng Jiang
Jie Cheng
Fumarate is a key metabolite produced primarily by the tricarboxylic acid (TCA) and urea cycles. In addition to having a metabolic role, its electrophilicity enables it to covalently modify cysteines; moreover, because of its α-ketoglutara...
(Poly)phenols as bioactive constituents linked to dietary fibre metabolic fate [0.03%]
多酚作为与膳食纤维代谢命运相关的生物活性成分
Jara Pérez-Jiménez,Yolanda Sanz,Rosa M Lamuela-Raventós
Jara Pérez-Jiménez
Lingling Wang,Qingyi Jia,Jinhan He et al.
Lingling Wang et al.
The increasing global prevalence of obesity presents a substantial challenge to public health. Current nutrient-stimulated hormone (NuSH)-based therapeutics are hindered by receptor desensitization, muscle loss, and weight regain. The adipo...
Yu Wang,Hou-Zao Chen,Xiaoqiang Tang
Yu Wang