Hahn Nahmgoong,Jae Bum Kim
Hahn Nahmgoong
The functional versatility of adipose tissue is mediated by various cell types and their capacity to transition between distinct functional states upon pathophysiological stimuli. Recent advances in single-cell transcriptomics have enabled ...
Adipose tissue-derived extracellular vesicles as drivers of endothelial dysfunction in obesity [0.03%]
肥胖相关脂肪组织源性外泌体诱导内皮功能障碍的作用机制研究
Daphne Lintsen,Lisa Schuetz,Paula Pincela Lins et al.
Daphne Lintsen et al.
Obesity and (white) adipose tissue (AT) inflammation are closely linked to endothelial dysfunction (ED) and neurological conditions associated with an impaired blood-brain barrier (BBB). AT-derived extracellular vesicles (AT-EVs), cell-deri...
Zhen Wang,Weiwei Yu,Di Wang
Zhen Wang
One-carbon (1C) metabolism serves as a central hub governing anabolism-supporting and epigenetic modification processes through its shunts, the tetrahydrofolate (THF) cycle, and the methionine cycle. The 1C shunts exhibit divergent characte...
Polyamines [0.03%]
多胺
Zhaoyi Li,Ziyan Xia,Peng Jiang
Zhaoyi Li
Yongrui Hai,Xuejing Duan,Gaofei Wei
Yongrui Hai
Cancer cachexia lacks effective therapies due to an incomplete understanding of its upstream drivers. A recent study by Morigny et al. identifies one-carbon metabolism as a conserved endocrine-metabolic program that links tumor signals to s...
Ren Zhang,Kezhong Zhang
Ren Zhang
The compartmentalization of NAD(H) and NADP(H) is fundamental to cellular metabolism, enabling precise coordination of redox balance, biosynthetic reactions, and energy homeostasis. Within mitochondria, NADP(H) has long been viewed as a red...
MetALD at the crossroads of metabolic and alcohol-related liver disease [0.03%]
代谢和酒精相关性肝病交叉路口的METALD
Gustavo Ayares,Luis Antonio Díaz,Juan Pablo Arab et al.
Gustavo Ayares et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD) are leading causes of global liver morbidity. Addressing the complex interplay of metabolic and alcohol-related factors has led to t...
Regulation of skeletal muscle mitochondrial fuel utilization during exercise [0.03%]
运动时骨骼肌线粒体燃料利用的调节机制研究进展
Likun Yang,Tingting Fu,Hao Yu et al.
Likun Yang et al.
Skeletal muscle exhibits remarkable metabolic plasticity, with mitochondria playing a central role in adapting to energy demands during exercise. These organelles form a dynamic and specialized system capable of remodeling to meet metabolic...
Brown adipose tissue and beyond: lipolysis and glycerolipid cycling in thermogenesis [0.03%]
褐色脂肪组织及其他：生热作用中的脂解和甘油酯周转
Dominique Langin,André C Carpentier
Dominique Langin
Following cold exposure, brown adipose tissue (BAT) generates heat through uncoupling protein 1-mediated thermogenesis. Intracellular lipolysis, mediated by neutral lipases, provides nonesterified fatty acids that fuel BAT mitochondrial res...
Exercise timing and circadian regulation of metabolism in type 2 diabetes [0.03%]
2型糖尿病的运动时间与昼夜节律代谢调节
Signe Schmidt Kjølner Hansen,Juleen R Zierath,Harriet Wallberg-Henriksson
Signe Schmidt Kjølner Hansen
The circadian system regulates daily rhythms in metabolism and hormone secretion; however, in type 2 diabetes, disrupted clock gene oscillations in skeletal muscle impair metabolic regulation. Insulin resistance, mitochondrial dysfunction, ...