Assessment and treatment of osteoporosis and fractures in type 2 diabetes [0.03%]
2型糖尿病患者的骨质疏松症和骨折的评估与治疗
Angela Sheu,Jerry R Greenfield,Christopher P White et al.
Angela Sheu et al.
There is substantial, and growing, evidence that type 2 diabetes (T2D) is associated with skeletal fragility, despite often preserved bone mineral density. As post-fracture outcomes, including mortality, are worse in people with T2D, bone m...
Xiong Weng,Samuel Maxwell-Warburton,Annie Hasib et al.
Xiong Weng et al.
CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its essential role in physiological activities in normal cells and pathological activities in cancer cells, such as cell proliferation, adhesion, and migra...
Alexey Moskalev,Zulfiya Guvatova,Ines De Almeida Lopes et al.
Alexey Moskalev et al.
Geroprotectors slow down aging and promote healthy longevity in model animals. Although hundreds of compounds have been shown to extend the life of laboratory model organisms, clinical studies on potential geroprotectors are exceedingly rar...
Jolien Vandewalle,Claude Libert
Jolien Vandewalle
Sepsis is involved in ~ 20% of annual global deaths. Despite decades of research, the current management of sepsis remains supportive rather than curative. Clinical trials in sepsis have mainly been focused on targeting the inflammatory pat...
Predrag Jovanovic,Celine E Riera
Predrag Jovanovic
Olfactory perception guides daily decisions regarding food consumption, social interactions, and predator avoidance in all mammalian species. Volatile inputs, comprising odorants and pheromones, are relayed to the olfactory bulb (OB) from n...
Luigi Ippolito,Pierre Sonveaux,Paola Chiarugi
Luigi Ippolito
The tumor ecosystem evolves with dynamic interactions between cancer and normal cells, and nutrients have emerged as new regulators of cancer hallmarks. Lactate has climbed the rankings as a multifunctional molecule orchestrating many aspec...
Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson's disease: (Trends in Endocrinology & Metabolism 33, 147-157; 2022) [0.03%]
近期研究的思考：帕金森病中的肠道α-突触核蛋白和菌群变化(Trends in Endocrinology & Metabolism 33, 147-157; 2022)
Ehraz Anis,Aoji Xie,Lena Brundin et al.
Ehraz Anis et al.
Jan Martel,Shih-Hsin Chang,Yun-Fei Ko et al.
Jan Martel et al.
The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic and extrinsic factors, including genetic predisposit...
Qin Tang,Yanping Li,Jinhan He
Qin Tang
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum-resident protein and a secretory factor and has beneficial effects in multiple diseases. Recent evidence shows that its circulating levels in humans are ...
Fathima Zahra Nawaz,Edward T Kipreos
Fathima Zahra Nawaz
Folates are B vitamins that function in one-carbon metabolism. Folate receptors are one of three major types of folate transporters. The folate receptors FOLR1 and FOLR2 are overexpressed in multiple cancers. The overexpression of FOLR1 is ...