Yasuhiro Onogi,Siegfried Ussar
Yasuhiro Onogi
Brown adipose tissue (BAT) is often considered as a sink for nutrients to generate heat. However, when the complex hormonal and nervous inputs and intracellular signaling networks regulating substrate utilization are considered, BAT appears...
SGLT-2 inhibitors and GLP-1 receptor agonists in metabolic dysfunction-associated fatty liver disease [0.03%]
代谢紊乱相关脂肪肝病中的SGLT-2抑制剂和GLP-1受体激动剂治疗
Jun Sung Moon,Jun Hwa Hong,Yong Jin Jung et al.
Jun Sung Moon et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition that affects nearly one billion people globally, characterized by triacylglycerol accumulation in the liver as a consequence of metabolic abnormalities (obe...
Jakob Triebel,Juan Pablo Robles,Magdalena Zamora et al.
Jakob Triebel et al.
Proteolysis of protein hormones is primarily acknowledged in the context of breakdown and metabolic clearance by hepatorenal elimination. However, less explored is the specific proteolytic processing of large protein hormones, for which can...
Metabolic changes favor the activity and heterogeneity of reactive astrocytes [0.03%]
代谢变化有利于反应性星形胶质细胞的活性和异质性
Xiao-Yi Xiong,Yong Tang,Qing-Wu Yang
Xiao-Yi Xiong
Reactive astrocytes undergo morphological, molecular, metabolic, and functional remodeling in response to central nervous system (CNS) damage. However, we still know very little about how the metabolic switching of astrocytes influences, or...
Gisela Pachón-Peña,Miriam A Bredella
Gisela Pachón-Peña
Recent studies have highlighted the role of bone marrow adipose tissue (BMAT) as a regulator of skeletal homeostasis and energy metabolism. While long considered an inert filler, occupying empty spaces from bone loss and reduced hematopoies...
Lessons from neonatal β-cell epigenomic for diabetes prevention and treatment [0.03%]
新生儿β细胞表观基因研究对糖尿病防治的启示
Amar Abderrahmani,Cécile Jacovetti,Romano Regazzi
Amar Abderrahmani
Pancreatic β-cell expansion and functional maturation during the birth-to-weaning period plays an essential role in the adaptation of plasma insulin levels to metabolic needs. These events are driven by epigenetic programs triggered by gro...
Shruti Bhargava,Sofia de la Puente-Secades,Leon Schurgers et al.
Shruti Bhargava et al.
Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foa...
Proteostasis and resilience: on the interphase between individual's and intracellular stress [0.03%]
稳态与韧性：个体和细胞应激之间的相互作用
Mei-Li Díaz-Hung,Claudio Hetz
Mei-Li Díaz-Hung
A long proportion of the population is resilient to the negative consequences of stress. Glucocorticoids resulting from endocrine responses to stress are essential adaptive mediators, but also drive alterations to brain function, negatively...
A matter of time: temporal structure and functional relevance of macrophage metabolic rewiring [0.03%]
时间问题：巨噬细胞代谢重组的时空结构及功能相关性
Gretchen L Seim,Jing Fan
Gretchen L Seim
The response of macrophages to stimulation is a dynamic process which coordinates the orderly adoption and resolution of various immune functions. Accumulating work over the past decade has demonstrated that during the immune response macro...
Growth variations with opposite clinical outcomes and the emerging role of IGF-1 [0.03%]
不同的生长模式及其临床意义和生长激素的新兴作用
Anastasios Papadimitriou,Chrisanthi Marakaki,Dimitrios T Papadimitriou
Anastasios Papadimitriou
Normal growth pattern variations [i.e., constitutional advancement and constitutional delay of growth and puberty (CAGP and CDGP)] are the mirror image of each other and are associated with early puberty (EP) and delayed puberty (DP), respe...