More trials for the unhappy hypothyroid patient on thyroxine: a clinician's perspective [0.03%]
甲状腺功能减退症患者的治疗试验：临床医生的视角
Timothy A Welborn
Timothy A Welborn
Further clinical trials are proposed for the 5-15% of hypothyroid patients who are dissatisfied with thyroxine (T4) monotherapy. Those responding to combination therapy [T4 plus triiodothyronine (T3)] will show suggestive biochemistry and a...
Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses [0.03%]
新型冠状病毒感染的神经学方面：脂蛋白和外泌体作为“特洛伊木马”
Sin Man Lam,Xun Huang,Guanghou Shui
Sin Man Lam
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets lipid-producing cells for viral tropism. In this review, we connect systemic lipid couriers, particularly high-density lipoproteins (HDLs) and exosomes, with the...
João Pessoa
João Pessoa
Lionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in...
Gilles Mithieux
Gilles Mithieux
The gut microbiota plays a crucial role in host health, providing energy and vitamins from food undigested by the gut enzymes of the host. Bacterial metabolites, such as short-chain fatty acids (SCFAs), are essentially metabolized by the gu...
Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis? [0.03%]
孤儿G蛋白偶联受体GPR146：实现胆固醇稳态的替代治疗途径？
Brendan P Wilkins,Angela M Finch,Yan Wang et al.
Brendan P Wilkins et al.
Atherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hyper...
Luisa Rodriguez,Catherine Dinauer,Gary Francis
Luisa Rodriguez
In 2014, treatment guidelines from the American Thyroid Association reflected the general consensus that levothyroxine (LT4), adjusted to maintain a normal thyrotropin (TSH) level, is the preferred method for treatment of hypothyroidism. Al...
Philippe Icard,Luca Simula
Philippe Icard
We discuss how metabolism changes during different phases of the cell cycle to sustain biosynthesis and replication in normal and cancer cells. We also highlight how several master regulators of cell cycle, such as cyclin-cyclin-dependent k...
Metabolic disorders on cognitive dysfunction after traumatic brain injury [0.03%]
创伤性脑损伤后代谢紊乱对认知功能障碍的影响
Jin-Qing Lai,Yan-Chuan Shi,Shu Lin et al.
Jin-Qing Lai et al.
Cognitive dysfunction is a common adverse consequence of traumatic brain injury (TBI). After brain injury, the brain and other organs trigger a series of complex metabolic changes, including reduced glucose metabolism, enhanced lipid peroxi...
Therapeutic opportunities to modulate immune tolerance through the metabolism-chromatin axis [0.03%]
通过代谢-染色体轴调节免疫耐受的治疗机会
Anne Lise Ferrara,Antonietta Liotti,Antonio Pezone et al.
Anne Lise Ferrara et al.
The ability of the immune system to discriminate external stimuli from self-components - namely immune tolerance - occurs through a coordinated cascade of events involving a dense network of immune cells. Among them, CD4+CD25+ T regulatory ...
Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease [0.03%]
与饮食和微生物群相关的代谢物5-氨基戊酸甜菜碱（5-AVAB）在健康和疾病中的作用
Retu Haikonen,Olli Kärkkäinen,Ville Koistinen et al.
Retu Haikonen et al.
5-Aminovaleric acid betaine (5-AVAB) is a trimethylated compound associated with the gut microbiota, potentially produced endogenously, and related to the dietary intake of certain foods such as whole grains. 5-AVAB accumulates within the m...