OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle [0.03%]
OPA1对骨骼肌和心肌线粒体动力学的调节作用
John Noone,Donal J O&#x;Gorman,Helena C Kenny
John Noone
The mitochondria are double-membrane organelles integral for energy metabolism. Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and OMM) proteins, which promote fission and fusion. Optic atrophy 1 (OPA1) r...
Benjamin Geffroy
Benjamin Geffroy
In recent years, observations of distinct organisms have linked the quality of the environment experienced by a given individual and the sex it will develop. In most described cases, facing relatively harsh conditions resulted in masculiniz...
Mesenchymal stromal cells as a tool to unravel the developmental origins of disease [0.03%]
利用间充质基质细胞揭示疾病的发育起源
Pia Todtenhaupt,Melissa van Pel,Arno A W Roest et al.
Pia Todtenhaupt et al.
The intrauterine environment can induce alterations of the epigenome that have a lasting impact on disease risk. Current human studies in the field focus on a single epigenetic mark, DNA methylation, measured in blood. For in-depth mechanis...
GLP-1 agonists: superior for mind and body in antipsychotic-treated patients? [0.03%]
GLP-1受体激动剂：能否改善抗精神病药所致躯体及精神损害？
Katerina Horska,Jana Ruda-Kucerova,Silje Skrede
Katerina Horska
Antipsychotics (APDs) represent a core treatment for severe mental disorders (SMEs). Providing symptomatic relief, APDs do not exert therapeutic effects on another clinically significant domain of serious mental disorders, cognitive impairm...
Marija Gjorgoska,Tea Lanisnik Rizner
Marija Gjorgoska
Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving mutational landscapes of endometrial tumors that hold great potential for tailoring t...
Jing-Fu Bao,Qin-Ying She,Pan-Pan Hu et al.
Jing-Fu Bao et al.
Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a mediator of exercise-induced metabolic improvements, such as brown...
Iron effects versus metabolic alterations in hereditary hemochromatosis driven bone loss [0.03%]
遗传性铁沉积病所致骨质疏松中的铁依赖效应与代谢改变的区别
Ulrike Baschant,Sandro Altamura,Peter Steele-Perkins et al.
Ulrike Baschant et al.
Hereditary hemochromatosis (HH) is a genetic disorder in which mutations affect systemic iron homeostasis. Most subtypes of HH result in low hepcidin levels and iron overload. Accumulation of iron in various tissues can lead to widespread o...
Pathogenic variants of the mitochondrial aspartate/glutamate carrier causing citrin deficiency [0.03%]
线粒体天冬氨酸/谷氨酸载体的致病突变导致的citrin缺乏症
Sotiria Tavoulari,Denis Lacabanne,Chancievan Thangaratnarajah et al.
Sotiria Tavoulari et al.
Citrin deficiency is a pan-ethnic and highly prevalent mitochondrial disease with three different stages: neonatal intrahepatic cholestasis (NICCD), a relatively mild adaptation stage, and type II citrullinemia in adulthood (CTLN2). The cau...
Carlos H Sponton,Jose Carlos de Lima-Junior,Luiz O Leiria
Carlos H Sponton
Owing to its unique capacity to clear macronutrients from circulation and use them to produce heat, thermogenic fat is capable of regulating glucose, lipids, and branched-chain amino acids (BCAA) circulatory levels. At the same time, its ac...
IFN-I signaling in cancer: the connection with dysregulated Insulin/IGF axis [0.03%]
干扰素I信号在癌症中的作用：与胰岛素/胰岛素样生长因子轴失调的关系
Veronica Vella,Ernestina Marianna De Francesco,Eduardo Bonavita et al.
Veronica Vella et al.
Type I interferons (IFN-Is) are prototypical inflammatory cytokines produced in response to stress. IFN-Is have a critical role in antitumor immunity by driving the activation of leukocytes and favoring the elimination of malignant cells. H...