Cortisol and cardiometabolic disease: a target for advancing health equity [0.03%]
皮质醇与心代谢病：促进健康公平的靶点
Robin Ortiz,Bjorn Kluwe,Sophie Lazarus et al.
Robin Ortiz et al.
Stress, in both intrinsic psychosocial and extrinsic physical environmental forms, can impact the development of, and outcomes in, cardiovascular disease (CVD) through allostatic load. Cortisol is a core hormonal mediator of allostatic load...
Nicolas Gutierrez-Castellanos,Basma F A Husain,Inês C Dias et al.
Nicolas Gutierrez-Castellanos et al.
Sex is fundamental for the evolution and survival of most species. However, sex can also pose danger, because it increases the risk of predation and disease transmission, among others. Thus, in many species, cyclic fluctuations in the conce...
PM2.5-induced adipose tissue dysfunction can trigger metabolic disturbances [0.03%]
PM2.5诱导的脂肪组织功能障碍可诱发代谢紊乱
Lucio Della Guardia,Andrew C Shin
Lucio Della Guardia
Exposure to particulate matter ≤2.5 μm in diameter (PM2.5) alters cardiometabolic homeostasis. The reduced oxidative capacity in brown adipocytes and the development of inflammation and insulin resistance in white adipose tissue (WAT) can...
NAFLD and thyroid function: pathophysiological and therapeutic considerations [0.03%]
非酒精性脂肪肝病与甲状腺功能：病理生理和治疗考量
Erifili Hatziagelaki,Stavroula A Paschou,Martin Schön et al.
Erifili Hatziagelaki et al.
Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic, but also extrahepatic, complications. Thyroid hormones are master regulators of energy and lipid homeostasis, and the presence of abnormal thyroid ...
David Aguilar-Recarte,Emma Barroso,Xavier Palomer et al.
David Aguilar-Recarte et al.
Although a large number of drugs are available for the treatment of type 2 diabetes mellitus (T2DM), many patients do not achieve adequate disease control despite adhering to medication. Recent findings indicate that the pharmacological mod...
Come out and play [0.03%]
出来玩玩吧
Marco Pagliusi Jr
Marco Pagliusi Jr
We all know that we should exercise so that we can reach a healthier physiological state. However, this knowledge is often not enough to prompt us to regularly engage in exercise. Here, I discuss why and what we could do to try to overcome ...
Michelangelo Certo,Alba Llibre,Wheeseong Lee et al.
Michelangelo Certo et al.
Metabolites generated from cellular and tissue metabolism have been rediscovered in recent years as signalling molecules. They may act as cofactor of enzymes or be linked to proteins as post-translational modifiers. They also act as ligands...
Martijn C G J Brouwers
Martijn C G J Brouwers
Evidence is accumulating that specifically fructose exerts adverse cardiometabolic effects in humans. Recent experimental studies have shown that fructose not only serves as a substrate for, among others, intrahepatic lipid formation, but a...
Immune-metabolic interactions in homeostasis and the progression to NASH [0.03%]
免疫代谢相互作用在稳态及向NASH进展中的作用
Joanne A Hoogerland,Bart Staels,David Dombrowicz
Joanne A Hoogerland
The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) and predisposes to fibrosis and hepatocellula...
Location matters: hexokinase 1 in glucose metabolism and inflammation [0.03%]
位置决定一切：己糖激酶1在葡萄糖代谢和炎症中的作用
Sivaraj M Sundaram,Luke A Doughty,Michael W Sereda
Sivaraj M Sundaram
Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidenc...