Sandeep Artham,Ching-Yi Chang,Donald P McDonnell
Sandeep Artham
Gender differences in the functionality of the immune system have been attributed, in part, to direct and indirect effects of sex steroids, especially estrogens, on immune cell repertoire and activity. Notable are studies that have defined ...
Angela Sheu,Jerry R Greenfield,Christopher P White et al.
Angela Sheu et al.
Type 2 diabetes (T2D) is associated with numerous complications, including increased risk of fragility fractures, despite seemingly protective factors [e.g., normal bone mineral density and increased body mass index(BMI)]. However, fracture...
Natalie M Garza,Abhinav B Swaminathan,Krishna P Maremanda et al.
Natalie M Garza et al.
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in diverse physiological processes, including mitochondrial energy generation. Copper enters cells through a dedicated copper transporter and is distributed...
Alexandra Wendler,Martin Wehling
Alexandra Wendler
Several receptors for nongenomically initiated actions of progesterone (P4) exist, namely membrane-associated P4 receptors (MAPRs), membrane progestin receptors (mPRs), receptors for neurosteroids [GABAA receptor (GABAAR), NMDA receptor, si...
Guy Stern
Guy Stern
Comparative analysis of high-intensity interval training (HIIT) suffers from a lack of standardized metrics for intervention programming. Given the huge amount of research and general public attention to exercise as medicine, understanding ...
Can sodium-glucose cotransporter 2 inhibitors 'spin the thread of life'? [0.03%]
钠-葡萄糖共转运蛋白2抑制剂能“延年益寿”吗？
Giuseppe Maltese,Theocharis Koufakis,Kalliopi Kotsa et al.
Giuseppe Maltese et al.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) were first used as antidiabetic agents that lower the blood glucose levels by promoting glycosuria. In recent years, randomised clinical trials have demonstrated that SGLT2i reduce cardiova...
Emerging role of T3-binding protein μ-crystallin (CRYM) in health and disease [0.03%]
三碘甲状腺原氨酸结合蛋白μ-结晶蛋白(CRYM)在健康和疾病中的新兴作用
Osman Aksoy,Brigitte Hantusch,Lukas Kenner
Osman Aksoy
Thyroid hormones are essential metabolic and developmental regulators that exert a huge variety of effects in different organs. Triiodothyronine (T3) and thyroxine (T4) are synthesized in the thyroid gland and constitute unique iodine-conta...
Mengwei Zang,Bin Gao
Mengwei Zang
Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight i...
Contributions of physical inactivity and sedentary behavior to metabolic and endocrine diseases [0.03%]
久坐和身体不活动对代谢及内分泌疾病的影响
Nathan R Kerr,Frank W Booth
Nathan R Kerr
Physical inactivity is the fourth leading global cause of death and is a major contributor to metabolic and endocrine diseases. In this review we provide a current update of the past 5 years in the field as it pertains to the most prevalent...
Cannabinoids and terpenes for diabetes mellitus and its complications: from mechanisms to new therapies [0.03%]
大麻素和萜类化合物在糖尿病及其并发症中的作用：从机制到新疗法
Esmaeel Ghasemi-Gojani,Igor Kovalchuk,Olga Kovalchuk
Esmaeel Ghasemi-Gojani
The number of people diagnosed with diabetes mellitus and its complications is markedly increasing worldwide, leading to a worldwide epidemic across all age groups, from children to older adults. Diabetes is associated with premature aging....