Alibek Moldakozhayev,Vadim N Gladyshev
Alibek Moldakozhayev
We propose a two-mode (pursuit/maintenance) model of metabolism defined by usable resource availability. Pursuit, consisting of anabolism and catabolism, dominates when usable resources are plentiful and leads to the generation of metabolic...
Corticosteroid-binding globulin (CBG): spatiotemporal distribution of cortisol in sepsis [0.03%]
皮质类固醇结合球蛋白(CBG)：脓毒症中皮质醇的时空分布
Jessica H Lee,Emily J Meyer,Marne A Nenke et al.
Jessica H Lee et al.
Corticosteroid-binding globulin (CBG) is a 50-60 kDa circulating glycoprotein with high affinity for cortisol. CBG is adapted for sepsis; its cortisol binding is reduced reversibly by pyrexia and acidaemia, and reduced irreversibly by neutr...
Frances M Ashcroft,Matthew Lloyd,Elizabeth A Haythorne
Frances M Ashcroft
Type 2 diabetes (T2D) is a global health problem characterised by chronic hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised to stimulate insulin release it was initially argued that drugs that stimulate...
N6-methyladenosine in macrophage function: a novel target for metabolic diseases [0.03%]
巨噬细胞功能中的N6-甲基腺苷：代谢疾病的新型治疗靶点
Xiao Zhu,HaoJun Tang,Min Yang et al.
Xiao Zhu et al.
N6-methyladenosine (m6A) is one of the most prevalent internal transcriptional modifications. Evidence has highlighted changes in m6A in metabolic disorders and various metabolic diseases. However, the precise mechanisms of these m6A change...
The controversy about the effects of artemisinins on pancreatic α cell reprogramming and diabetes [0.03%]
关于青蒿素对胰岛α细胞重编程和糖尿病影响的争议
Yufeng Zhang,Xinrui Lin,Jin Li
Yufeng Zhang
It has been reported that artemisinin treatment induces β cell regeneration and alleviates hyperglycemia, although the therapeutic potential and mechanism have been questioned by various groups. We discuss the existing evidence and future ...
Joshua D Gross,Yang Zhou,Lawrence S Barak et al.
Joshua D Gross et al.
As allosteric complexes, G-protein-coupled receptors (GPCRs) respond to extracellular stimuli and pleiotropically couple to intracellular transducers to elicit signaling pathway-dependent effects in a process known as biased signaling or fu...
Sarah Mele,Felipe Martelli,Jiayi Lin et al.
Sarah Mele et al.
Amino acid disorders (AADs) are a large group of rare inherited conditions that collectively impact one in 6500 live births, often resulting in rapid neurological decline and death during infancy. For several AADs, including phenylketonuria...
Dured Dardari
Dured Dardari
The pathophysiology of Charcot neuroarthropathy (CN) includes a number of gray areas, particularly regarding the onset of inflammation which induces the disruption of the bone remodeling factor responsible for the onset of bone lysis. This ...
'Rotor free-wheeling' in impaired F1FO-ATPase induces congenital hypermetabolism [0.03%]
受损F1FO-ATP酶中'转子自由轮动'诱导先天性高代谢症
Salvatore Nesci,Giovanni Romeo
Salvatore Nesci
A de novo heterozygous variant in the catalytic subunit of mitochondrial F1FO-ATPase has been recently discovered by Ganetzky et al. to be the main cause of an autosomal dominant syndrome of hypermetabolism associated with defective ATP pro...
Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal [0.03%]
糖尿病大血管并发症中的高级糖基化终末产物：着重于甲基乙二醛
Casper G Schalkwijk,Linda Renata Micali,Kristiaan Wouters
Casper G Schalkwijk
Diabetes is associated with vascular injury and the onset of macrovascular complications. Advanced glycation endproducts (AGEs) and the AGE precursor methylglyoxal (MGO) have been identified as key players in establishing the relationship b...