Xiaoyun Su,Zhenzhen Hao,Bin Yao
Xiaoyun Su
Tiny amounts of exogenous enzymes entering the plasma can exert important health-promoting functions. We propose that orally administered enzymes can potentially translocate across the gut barrier to combat reduced fitness and diseases conc...
Kequan Xu,Peng Xia,Xi Chen et al.
Kequan Xu et al.
The challenges of hepatocellular carcinoma (HCC) pathogenesis, diagnosis, treatment, and prognosis evaluation are obvious. Hepatocyte-specific fatty acid (FA) metabolic reprogramming is an important marker of liver carcinogenesis and progre...
Jacco J A J Bastings,Koen Venema,Ellen E Blaak et al.
Jacco J A J Bastings et al.
Recent studies show a link between the gut microbiota and the regulation of satiety and energy intake, processes that contribute to the development and pathophysiology of metabolic diseases. However, this link is predominantly established i...
Meliha Melin Uygur,Stefano Frara,Luigi di Filippo et al.
Meliha Melin Uygur et al.
Pituitary hormones regulate skeletal physiology, and excess levels affect bone remodeling and alter bone microstructure. Vertebral fractures (VFs) are an early phenomenon of impaired bone health in secreting pituitary adenomas. However, the...
Gonadotropins as pharmacological agents in assisted reproductive technology and polycystic ovary syndrome [0.03%]
辅助生殖技术和多囊卵巢综合征中的促性腺激素药物作用机制研究进展
Rita Singh,Surleen Kaur,Suman Yadav et al.
Rita Singh et al.
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy associated with subfertility/infertility and pregnancy complications. Most PCOS women opt for assisted reproductive technologies (ART) for successful conception; however, optimiza...
First-phase insulin secretion: can its evaluation direct therapeutic approaches? [0.03%]
一相胰岛素分泌检测及其指导治疗的意义
Gianfranco Di Giuseppe,Gea Ciccarelli,Laura Soldovieri et al.
Gianfranco Di Giuseppe et al.
Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance and with β cell function and mass. Starting from path...
Qi Zhang,Michael J Krashes
Qi Zhang
Calculating and selecting what sensory and homeostatic requirements to attend to at any given time is vital for animals' survival. Tang et al. uncovered a circuit emanating from excitatory cortical neurons that transmit nociceptive informat...
Maria A Frias,Ahmet Hatipoglu,David A Foster
Maria A Frias
mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural find...
mTORC1 syndrome (TorS): unified paradigm for diabetes/metabolic syndrome [0.03%]
糖尿病/代谢综合征的统一体系-MTORC1综合征(TorS)
Jacob Bar-Tana
Jacob Bar-Tana
'Glucolipotoxicity' and 'insulin resistance' are claimed to drive type 2 diabetes (T2D) and the non-glycemic diseases of the metabolic syndrome (MetS) (obesity, dyslipidemia, hypertension). In line with that, glycemic and/or insulin control...
Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine [0.03%]
中药疗效评估、活性成分及多靶标探索
Jun-Ling Ren,Le Yang,Shi Qiu et al.
Jun-Ling Ren et al.
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various diseases. However, complexities present in HM due to the unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, and nons...