Julia Ugras,Costas A Lyssiotis
Julia Ugras
Liankui Zhou,Ying Liu
Liankui Zhou
The mitochondrial unfolded protein response (UPRmt) is a transcriptional program that alleviates mitochondrial dysfunction by facilitating the recovery of the mitochondrial network. In Caenorhabditis elegans, reproductive maturity leads to ...
Almudena Veiga-Lopez,Elana R Elkin,Sean M Harris et al.
Almudena Veiga-Lopez et al.
Despite the crucial role of the placenta in supporting pregnancy and fetal development, research into its susceptibility to environmental exposures has been limited by methodological challenges. We review diverse approaches to studying plac...
Understanding metabolic resilience by unraveling temporal dynamics of cellular responses [0.03%]
揭示细胞反应时间动态以理解代谢韧性
Paniz Jasbi,Alex E Mohr,Meghana Hosahalli Shivananda Murthy et al.
Paniz Jasbi et al.
Metabolic resilience is essential for organismal homeostasis under diverse external pressures, because responding and adapting to stressors requires energy and drives changes at every omic level. The goal of this paper is to synthesize rece...
Wenqiang Chen,Stephanie Kullmann,Elizabeth M Rhea
Wenqiang Chen
Insulin resistance is a central feature of metabolic disorders such as type 2 diabetes (T2D). While studies on this disorder have largely been linked to glucose metabolism and intracellular signaling, recent advances reveal that insulin res...
Zi-Qing Zheng,Liang Shen,Li-Ming Zhao et al.
Zi-Qing Zheng et al.
The rising prevalence of depressive disorder worldwide requires better interventional avenues. B vitamins are gaining increasing interest as potential therapeutic approaches in this context given current evidence for a bidirectional associa...
Xiaochen Wang,Zhiyu Qiu,Zhenyu Zhong et al.
Xiaochen Wang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the global population and spans a spectrum of liver abnormalities, including simple steatosis, inflammation, fibrosis, cirrhosis, and hepatocellular carcin...
Julia Füreder,Eva S Schernhammer,A Heather Eliassen et al.
Julia Füreder et al.
Breast cancer (BC) remains the most prevalent malignancy among women worldwide. While genetic predisposition and reproductive history are key contributors to its development, modifiable risk factors are also important, particularly those li...
Julianna G Supplee,Ronen Marmorstein,Kathryn E Wellen
Julianna G Supplee
Disorders of lipid metabolism, including hyperlipidemia, atherosclerosis, and metabolic dysfunction-associated steatotic liver disease, are increasing across the globe. Bempedoic acid (BPA) is a first-in-class drug for the treatment of hype...
Healthy choices, healthy futures: promoting healthy nutrition to curb non-communicable diseases [0.03%]
健康选择，健康未来——促进健康饮食以控制非传染性疾病
Saurabh Kumar Gupta,Tina Rawal,Monika Arora
Saurabh Kumar Gupta
Non-communicable diseases (NCDs) pose a serious challenge to global public health, compounded by unhealthy nutrition and obesogenic environments. This science and society article emphasizes several evidence-based behavior-change strategies,...