Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis [0.03%]
肝内从头合成脂质的底物供给、隔室划分及利用方式
Daniel J Pape,Eric B Taylor
Daniel J Pape
Hepatic de novo lipogenesis (DNL) is a fundamental process that supports energy storage, membrane biogenesis, and lipid signaling. However, chronically elevated hepatic DNL is a risk factor for insulin resistance and liver fat accumulation....
Gabriel Á Martos-Moreno,Blanca Guijo,Manuel Tena-Sempere et al.
Gabriel Á Martos-Moreno et al.
Advances in our understanding of hypothalamic control of energy homeostasis have resulted in the identification of genetic forms of obesity, both syndromic and nonsyndromic, with some precision treatments now being employed. In this review ...
The 3M roles of the gut microbiome in pharmacotherapy for diabetes: mediator, modifier, and marker [0.03%]
肠道微生态在糖尿病药理治疗中的三种作用：介质、修正和标志物
Jeong In Seo,Ara Koh,Soo Lim et al.
Jeong In Seo et al.
The rising global prevalence of type 2 diabetes mellitus (T2DM) presents major challenges to healthcare systems; thus, more effective treatment strategies are urgently needed. In this context, the growing recognition of the gut microbiome's...
The immunoregulatory role of progesterone during embryo implantation and pregnancy [0.03%]
孕酮在胚胎着床和妊娠中的免疫调节作用
Alessandra Colamatteo,Fortunata Carbone,Clorinda Fusco et al.
Alessandra Colamatteo et al.
Progesterone (P4), the 'pregnancy hormone', plays a pivotal role in the establishment and maintenance of pregnancy by modulating maternal immune responses, thereby promoting immune tolerance toward the semi-allogeneic fetus. In this review,...
Philippe Icard,Laurent Plard,Stéphane Allouche et al.
Philippe Icard et al.
Citrate metabolism remains poorly understood during mitosis, raising unresolved questions about citrate dynamics, compartmentalization, and targeting in cancer. Here, we propose a comprehensive model to explain how ATP-citrate lyase degrada...
Enzo Nisoli,Maurizio Ragni,Chiara Ruocco et al.
Enzo Nisoli et al.
Mitochondrial dysfunction, circadian disruption, and the accumulation of senescent cells converge to impair metabolic flexibility, a unifying phenotype of obesity and aging. We frame obesity as a nutrient-driven and aging as a time-driven e...
Fudi Wang
Fudi Wang
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global epidemic, with its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), driving cirrhosis and hepatocellular carcinoma. Ferroptosis, an iron...
Xavier Palomer,Ricardo Rodríguez-Calvo,Marta Tajes et al.
Xavier Palomer et al.
The most common dietary and plasma fatty acids (FAs), palmitic and oleic acids, have opposing effects on the risk of developing insulin resistance and type 2 diabetes mellitus (T2DM). Palmitic acid has been strongly associated with the pres...
Hiroshi Ohno
Hiroshi Ohno
Andrew J Elmendorf,Jonathan D Douros,Patrick J Knerr et al.
Andrew J Elmendorf et al.
Incretin-based therapies have transformed obesity and type 2 diabetes treatment. While current therapeutics safely reduce food intake and lower body weight, a compensatory drop-in basal metabolic rate represents a barrier to sustainable wei...