Alexander Behnke,Evan Shaulson,Herman Pontzer et al.
Alexander Behnke et al.
Evolved constraints to human energy transformation force the body-brain system to operate an economy of energy. To survive and thrive, an organism's finite internal energy resources must be dynamically reallocated, forcing trade-offs from o...
H19 long noncoding RNA in maternal obesity-driven metabolic programming [0.03%]
母体肥胖驱动代谢编程中的H19长链非编码RNA
Sharmeen Islam,Min Du
Sharmeen Islam
Maternal obesity alters H19 expression, disrupting epigenetic modifications during embryonic development, impairing muscle development, promoting fibrogenesis, and perturbing metabolic homeostasis, thereby predisposing offspring to fibrosis...
A fuel partitioning perspective on appetite suppression by GLP-1 receptor agonists [0.03%]
从燃料分配的角度探讨GLP-1受体激动剂的抑制食欲作用
Mark I Friedman,Jens Lund
Mark I Friedman
Appetite suppression by glucagon-like peptide-1 receptor agonists (GLP-1RAs) is thought to result from direct actions on neural circuits controlling food intake. In this article, we (1) propose that a shift in fuel partitioning toward fat o...
Understanding hypoparathyroidism as a disease of broad functional deficiency [0.03%]
理解低甲状旁腺素血症是一种功能广泛缺失的疾病
Maria Luisa Brandi,Jean-Philippe Bertocchio,Istvan Takacs et al.
Maria Luisa Brandi et al.
Hypoparathyroidism (HypoPT) is a rare disease defined by undetectable, low, or inappropriately normal parathyroid hormone (PTH) concentrations in the presence of hypocalcemia. Calcium and active vitamin D are often used for the treatment of...
Khaled Tighanimine,Brendan D Manning
Khaled Tighanimine
Tumor cells can thrive in nutrient-scarce environments. Glucose deprivation can trigger adaptive responses that coordinate cell-cell communication within the tumor microenvironment (TME). Recently, Luciano-Mateo et al. demonstrated that glu...
Sara Della Torre
Sara Della Torre
Glycine (aminoacetic acid) [0.03%]
甘氨酸（氨甲酸）
Jinwang Hou,Xugang Luo,Chuanlong Wang
Jinwang Hou
Amylin [0.03%]
胰岛素折叠蛋白淀粉样沉淀病
Giulia Mazzini,Thomas A Lutz
Giulia Mazzini
Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives [0.03%]
脂质信号网络在胰腺癌进展及治疗中的作用和前景分析
Andrea Costamagna,Giulia Milan,Maria Chiara De Santis et al.
Andrea Costamagna et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, driven by aggressive biology, profound therapy resistance, and scarce treatment options. Beyond classical metabolic rewiring, recent discoveries reveal that lipid...
Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation [0.03%]
转换燃料，加大热量！肉碱合成作为生理适应的介质
Nicolai R Hathiramani,Alexandra E Jerrett,Jessica B Spinelli
Nicolai R Hathiramani
To what extent does de novo carnitine synthesis in tissues dictate their fuel preference? Recently, Auger et al. identified Solute Carrier 25A45 (SLC25A45) as a mitochondrial trimethyllysine importer for carnitine biosynthesis. SLC25A45 ena...