Yehua Li,Xiaodong Wang
Yehua Li
Copper (Cu) is an essential trace element that plays a fundamental role in various biological processes, including electron transfer and enzymatic reactions. Cu homeostasis is tightly regulated by transporters, including CTR1 and ZnT1, that...
Industrialized diets modulate host eating behavior via the microbiome-gut-brain axis [0.03%]
工业化饮食通过微生物群-肠-脑轴调节宿主摄食行为
Yi Jia Liow,Amar Sarkar,Rachel N Carmody
Yi Jia Liow
The gut microbiome is an important participant in the gut-brain axis and a key mediator of host-diet interactions that shape feeding behavior. These effects occur through microbial metabolism of dietary components - fiber, sugar, fat, and p...
Daniel Jimenez-Blasco,Rebeca Lapresa,Jesus Agulla et al.
Daniel Jimenez-Blasco et al.
Neurons are exceptionally energy-demanding cells but have limited energy storage, relying on a constant supply of fuel and oxygen. Although glucose is the brain's main energy source, neurons reduce glycolysis under normal conditions. This s...
Miao Sun,Weidong Mi
Miao Sun
Brain insulin resistance (BIR) contributes to neurodegenerative diseases such as Alzheimer's disease (AD). Recently, Chen et al. revealed that microglial insulin signaling loss drives neuroinflammation and amyloid-β (Aβ) accumulation, pro...
Targeting cardiometabolic risk in type 1 diabetes through incretin physiology [0.03%]
通过肠泌肽生理学作用降低1型糖尿病患者的心血管代谢风险
Ruth Frampton,Samantha Hocking,Jennifer R Snaith et al.
Ruth Frampton et al.
People living with type 1 diabetes have significantly increased cardiovascular risk compared with the general population. Traditional risk factors include hypertension, dyslipidaemia, and obesity. However, those with type 1 diabetes contend...
Unraveling the sweet connection between pancreatic cancer and hyperglycemia [0.03%]
揭秘胰腺癌与高血糖之间的甜蜜联系
Zoë Post,Dauris Rosario Lora,Wojciech Blogowski
Zoë Post
Pancreatic adenocarcinoma (PaC) is one of the deadliest cancers, primarily due to late-stage diagnosis and limited treatment options. A bidirectional relationship exists between PaC and diabetes mellitus (DM), where glucose abnormalities bo...
Zhangtie Wang,Changzheng Yuan,Tao Huang et al.
Zhangtie Wang et al.
Current research on inflammatory disorders tends to focus on the advanced stages of disease; however, acting against chronic low-grade inflammation (a stage before overt disease) through early nutritional interventions may be an alternative...
Takeshi Yoneshiro,Makoto Arai,Juro Sakai
Takeshi Yoneshiro
Heme has remarkable functions in mitochondrial energetics. Recently, Duerre et al. found that branched-chain amino acids (BCAA) are preferentially utilized for heme biosynthesis to facilitate mitochondrial thermogenesis in brown fat. Disrup...
Ananya Hota,Anton M Bennett
Ananya Hota
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are essential regulators of MAPK signaling pathways. MKPs perform critical roles in various cellular responses by dephosphorylating the regulatory residues and thereby inactivating...
Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise [0.03%]
运动引起的骨骼肌适应中的线粒体先天免疫信号转导
Jin Ma,Annie Yujin Son,Youlim Son et al.
Jin Ma et al.
Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial by promoting metabolic adaptation which, for example, decreases obesity and lowers the risk o...