Sang Mun Han,Hahn Nahmgoong,Kyung Min Yim et al.
Sang Mun Han et al.
Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an ...
Yoshitaka Sakurai,Naoto Kubota,Takashi Kadowaki
Yoshitaka Sakurai
The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesit...
Gregory E Demas,Yuqi Han,Hannah F Fink
Gregory E Demas
Maternal-fetal mechanisms underlying adaptation to hypoxia during early pregnancy [0.03%]
妊娠早期适应低氧应激的母胎机制研究进展
Indrani C Bagchi,Milan K Bagchi
Indrani C Bagchi
During the process of implantation, the embryo first attaches to the uterine epithelium and then invades the underlying stroma, resulting in the transformation of the stroma into a secretory tissue that surrounds the embryo. An intricate di...
Xiaoyan Yang,Bing Zhou
Xiaoyan Yang
Axon regeneration requires the mobilization of intracellular resources, including proteins, lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the biosynthetic demands needed to achieve axonal regeneration...
Autophagy and lysosomal dysfunction in diabetes and its complications [0.03%]
自噬和溶酶体功能障碍在糖尿病及其并发症中的作用
Catherine Arden,Seo H Park,Xaviera Riani Yasasilka et al.
Catherine Arden et al.
Autophagy is critical for energy homeostasis and the function of organelles such as endoplasmic reticulum (ER) and mitochondria. Dysregulated autophagy due to aging, environmental factors, or genetic predisposition can be an underlying caus...
Maria E R Garcia-Rendueles,Luis Varela,Tamas L Horvath
Maria E R Garcia-Rendueles
Shweta Tiwary,Cristina D Guerena,Jenna L Jewell
Shweta Tiwary
The intestine is a proliferative tissue subjected to a variety of stresses that disturb its homeostasis. A recent study by Tucker et al. demonstrated that loss of the tumor suppressor SIRT4 leads to increased cell proliferation via the de n...
Panwei Song,Zhi Peng,Xiaohuan Guo
Panwei Song
The gut microbiota plays a crucial role in maintaining homeostasis and promoting health. A growing number of studies have indicated that gut microbiota can affect cancer development, prognosis, and treatment through their metabolites. By re...
Non-SCFA microbial metabolites associated with fiber fermentation and host health [0.03%]
与纤维发酵和宿主健康相关的非SCFA微生物代谢物
Erica T Grant,Hélène De Franco,Mahesh S Desai
Erica T Grant
Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for other microbial metabolites in shaping host health. In th...