Jennifer van der Laan,Filipe Cabreiro
Jennifer van der Laan
Interactions between the gut microbiome, nutrients, drugs, and host physiology are inherently complex. Gut microbes contribute significantly towards host homeostasis and can modulate host-targeted drugs, affecting therapeutic outcomes. Find...
Luxia Yao,Lei Wang,Runshuai Zhang et al.
Luxia Yao et al.
Metformin, an oral antihyperglycemic drug that has been in use for over 60 years, remains a first-line therapy for type 2 diabetes (T2D). Numerous studies have suggested that metformin promotes health benefits beyond T2D management, includi...
Zhen Zhang,Renlei Yang,Zhike Zi et al.
Zhen Zhang et al.
Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are conv...
Muhammad Naveed,Kathryn Smedlund,Qi-Gang Zhou et al.
Muhammad Naveed et al.
Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety of brain parameters including neuronal energy metabolism. Exciting recent studies have shown that obesity and diabetes can impact on astrocyte func...
Inuk Zandvakili,Diego Perez-Tilve
Inuk Zandvakili
Despite sharing incretin activity with glucagon-like peptide 1 (GLP-1), the development of gastric inhibitory polypeptide (GIP)-based drugs has been hindered by the minor effects of native GIP on appetite and body weight and genetic studies...
Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases [0.03%]
线粒体与NAD+代谢在心代谢病中的相互作用的新进展
Azadeh Nasuhidehnavi,Weronika Zarzycka,Ignacy Górecki et al.
Azadeh Nasuhidehnavi et al.
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD+ and mitochondria, with consequences for mitochondrial function....
Benjamin J Dwyer,Janina E E Tirnitz-Parker
Benjamin J Dwyer
Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are e...
Mindy Kim,Ze Zheng
Mindy Kim
Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of ...
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts [0.03%]
具有代谢和内分泌干扰影响的持久性污染物全氟和多氟烷基物质
Lucas Gaillard,Robert Barouki,Etienne Blanc et al.
Lucas Gaillard et al.
The widespread use of per- and polyfluoroalkyl substances (PFASs), and their resistance to degradation, renders human exposure to them inevitable. PFAS exposure disturbs endocrine function, potentially affecting cognitive development in new...
Exploring the heterogeneous targets of metabolic aging at single-cell resolution [0.03%]
单细胞分辨率下探究代谢衰老的异质性目标
Shuhui Sun,Mengmeng Jiang,Shuai Ma et al.
Shuhui Sun et al.
Our limited understanding of metabolic aging poses major challenges to comprehending the diverse cellular alterations that contribute to age-related decline, and to devising targeted interventions. This review provides insights into the het...