Activating Calcium-Sensing Receptor Mutations: Prospects for Future Treatment with Calcilytics [0.03%]
钙敏感受体突变的激活：未来使用 calcilytics 进行治疗的前景
Bernhard Mayr,Markus Glaudo,Christof Schöfl
Bernhard Mayr
Activating mutations of the G protein-coupled receptor, calcium-sensing receptor (CaSR), cause autosomal dominant hypocalcemia and Bartter syndrome type 5. These mutations lower the set-point for extracellular calcium sensing, thereby causi...
Sudharsana R Ande,K Hoa Nguyen,B L Grégoire Nyomba et al.
Sudharsana R Ande et al.
Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB ...
Deborah L Johnson,Bangyan L Stiles
Deborah L Johnson
PTEN is a critical tumor suppressor whose dysregulation leads to metabolic disease and cancer. How these diseases are linked at a molecular level is poorly understood. Maf1 is a novel PTEN target that connects PTEN's ability to repress intr...
Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans [0.03%]
揭秘模式生物小胶虫代谢、寿命和行为之间的联系
George A Lemieux,Kaveh Ashrafi
George A Lemieux
An overview of Caenorhabditis elegans as an experimental organism for studying energy balance is presented. Some of the unresolved questions that complicate the interpretation of lipid measurements from C. elegans are highlighted. We review...
Jens Lund,Matthew Paul Gillum
Jens Lund
Upon activation, brown and beige adipocytes help to fight excessive fat in rodents, and their oxidative properties can be induced by cooling, capsinoids, and fish oil. New research now suggests that synergistic anti-obesity effects can be a...
Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis [0.03%]
脂肪祖细胞在组织发育、稳态、扩张和产热中的新兴作用
Daniel C Berry,Yuwei Jiang,Jonathan M Graff
Daniel C Berry
Stem or progenitor cells are an essential component for the development, homeostasis, expansion, and regeneration of many tissues. Within white adipose tissue (WAT) reside vascular-resident adipose progenitor cells (APCs) that can prolifera...
Current and Emerging Aspects of Diabetes Mellitus in Acromegaly [0.03%]
阿克罗梅格里症的糖尿病 mellitus 的当前和新出现方面
Stefano Frara,Filippo Maffezzoni,Gherardo Mazziotti et al.
Stefano Frara et al.
Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant stat...
Triin Laisk-Podar,Cecilia M Lindgren,Maire Peters et al.
Triin Laisk-Podar et al.
Ovarian function is central to female fertility, and several genome-wide association studies (GWAS) have been carried out to elucidate the genetic background of traits and disorders that reflect and affect ovarian physiology. While GWAS hav...
Josephine M Forbes
Josephine M Forbes
A recent study has highlighted the relationship between mitochondrial ATP generation and protection against organ injury following ischaemia-reperfusion injury in the kidney. Kidneys are fuel-hungry organs and only second to the heart in mi...
Christopher M Henstridge,Andrew J Brown,Maria Waldhoer
Christopher M Henstridge
Since the discovery of the lysophospholipid-sensitive receptor GPR55, hopes have been raised that targeting this G protein-coupled receptor (GPCR) may represent a novel approach for the treatment of metabolic disorders. We discuss conflicti...