The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications [0.03%]
IL-1途径与2型糖尿病及其心血管并发症的关系
Christian Herder,Elise Dalmas,Marianne Böni-Schnetzler et al.
Christian Herder et al.
Patients with type 2 diabetes (T2D) exhibit chronic activation of the innate immune system in pancreatic islets, in insulin-sensitive tissues, and at sites of diabetic complications. This results from a pathological response to overnutritio...
Bhagirath Chaurasia,Scott A Summers
Bhagirath Chaurasia
In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage induces cellular dysfunction that underlies diabetes and cardiovascular disease (i.e., lipotoxicity). Of the myriad lipids that accrue under these co...
The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease [0.03%]
内源大麻素系统：肥胖与代谢性疾病的决定性调节因素
Wilfrid Mazier,Nicolas Saucisse,Blandine Gatta-Cherifi et al.
Wilfrid Mazier et al.
The endocannabinoid system (ECS) functions to adjust behavior and metabolism according to environmental changes in food availability. Its actions range from the regulation of sensory responses to the development of preference for the consum...
Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space? [0.03%]
大网膜间皮细胞：居安思危还是仅仅占位呢？
Olga T Gupta,Rana K Gupta
Olga T Gupta
Visceral adiposity and pathological adipose tissue remodeling, a result of overnutrition, are strong predictors of metabolic health in obesity. Factors intrinsic to visceral adipose depots are likely to play a causal role in eliciting the d...
Insulin-Mediated Diseases: Adrenal Mass and Polycystic Ovary Syndrome [0.03%]
胰岛素介导的疾病：肾上腺肿块和多囊卵巢综合征
Giovanna Muscogiuri,Annamaria Colao,Francesco Orio
Giovanna Muscogiuri
Adrenal incidentalomas (AIs) and polycystic ovary syndrome (PCOS) have often been associated with compensatory hyperinsulinemia and insulin resistance (IR). The link between these diseases and IR may be changes in hormone secretions that pr...
GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases [0.03%]
GPR43——一种原型代谢物传感器 将代谢疾病和炎症疾病联系起来
Craig I McKenzie,Charles R Mackay,Laurence Macia
Craig I McKenzie
Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modula...
Cholsoon Jang,Zolt Arany
Cholsoon Jang
Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance vi...
Christoforos Thomas,Jan-Åke Gustafsson
Christoforos Thomas
Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activ...
Michael Rosenbaum,Rob Knight,Rudolph L Leibel
Michael Rosenbaum
Numerous studies of rodents suggest that the gut microbiota populations are sensitive to genetic and environmental influences, and can produce or influence afferent signals that directly or indirectly impinge on energy homeostatic systems a...
Pura Muñoz-Cánoves,Antonio L Serrano
Pura Muñoz-Cánoves
Defective muscle regeneration is usually accompanied by excessive matrix accumulation (fibrosis). A recent study reveals how this fibrotic process is prevented to allow successful regeneration, through a timely interplay between macrophages...