Wanqian Guo,Wusheng Xiao
Wanqian Guo
In a recent Cell study, Zuo et al. identified pyruvylation as a previously unrecognized post-translational modification (PTM) mechanism that suppresses type I interferon signaling and antiviral immunity through pyruvate-mediated pyruvylatio...
Indole-3-propionic acid [0.03%]
印防己碱
Qinlin Luo,Shuyi Mi,Dingjiacheng Jia
Qinlin Luo
Extracellular ligand-pseudokinase axis rewires lipid metabolism in steatohepatitis [0.03%]
细胞外配体假激酶轴重新布线steatohepatitis中的脂质代谢
Zhibo Shen,Tianyu Jiang,Pengfei Xu
Zhibo Shen
Metabolic dysfunction-associated steatohepatitis is traditionally viewed as a hepatocyte-autonomous metabolic disorder. A recent study by Xi et al. identifies a soluble glycoprotein nonmetastatic melanoma protein B ectodomain that activates...
Andrea Moro,Paolo Santambrogio,Sonia Levi
Andrea Moro
Brain iron dysregulation is linked to stress-related disorders, but its functional role remains opaque. Wang et al. define 'ferroplasticity', a form of experience-dependent, iron-mediated synaptic remodeling driven by a glucocorticoid-trans...
The role of noradrenergic innervation and β-cell dedifferentiation in diabetes [0.03%]
去甲肾上腺素能神经元轴突末端缺失和β细胞脱分化在糖尿病发病中的作用研究
Adriana Avolio,Cassandra Morciano,Shawn Gugliandolo et al.
Adriana Avolio et al.
β-Cell dedifferentiation is a key mechanism of β-cell failure in type 2 diabetes (T2D). To survive metabolic stress, β-cells adopt a progenitor-like state, allowing for potential redifferentiation and T2D remission when conditions improv...
Yuqing Zhang,Zi-Jiang Chen,Han Zhao
Yuqing Zhang
Parental metabolic health prior to conception can shape offspring's metabolic risk through germline epigenetic reprogramming. This forum advances a preconception-centered, dual-germline prevention paradigm that positions interventions befor...
Physiological mechanisms mediating socio-environmental influences on pregnancy outcomes in Black people [0.03%]
影响黑人妊娠结局的社经济社会因素的作用机制
Grace E A Amedor,Dino A Giussani
Grace E A Amedor
Black women and their infants experience higher mortality rates than their White counterparts. While systemic racism, socioeconomic disadvantage, and environmental stressors are recognized contributors, physiological pathways that mediate t...
Mechanics, inflammation, and metabolism as integrated drivers of heart failure [0.03%]
力学、炎症和代谢在心力衰竭中的相互作用及驱动因素
Ramona Emig,Pilar Alcaide
Ramona Emig
Heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Mechanical remodeling of the cardiac extracellular matrix (ECM) impairs cardiomyocyte contractility and causes cardiac stiffening. Chronic low-grade inflammati...
Flavia A Cimini,Aida Cuenca-Royo,Maria Gomis-Gonzalez et al.
Flavia A Cimini et al.
Type 2 diabetes (T2D) is increasingly associated with cognitive impairment and dementia, reflecting the combined impact of metabolic dysregulation, vascular injury, neuroinflammation, and defective brain insulin signaling. While this link i...
Cholesterol-LXR axis in metabolic regulation of liver fibrosis and hepatocarcinogenesis [0.03%]
胆固醇-LXR轴在肝纤维化和肝细胞癌代谢调控中的作用
Elena Piccinin,Gaetano Villani,Antonio Moschetta
Elena Piccinin
Metabolic dysfunction-associated steatotic liver disease is increasing worldwide, and its progression to metabolic dysfunction-associated steatohepatitis (MASH) and ultimately hepatocellular carcinoma (HCC) remains a major clinical challeng...