Glucagon receptor antagonism requires further mechanistic attention on α-cell physiology [0.03%]
胰高血糖素受体拮抗作用需要进一步关注α细胞生理学机制
Jianxin Jia,Zhehui Li,Liyuan Zhao et al.
Jianxin Jia et al.
Glucagon receptor (GCGR) antagonism improves glycemic control; however, it also brings adverse effects through unclear underlying mechanisms. Here, we summarize emerging findings about the impact of GCGR blockade on α cells and discuss the...
Spatiotemporal coordination between local flux and systemic homeostasis in the small intestine [0.03%]
小肠局部物质传输与全身稳态的时空协调关系研究
Jian Zhang,Siwen Zhang,Liheng Du et al.
Jian Zhang et al.
The small intestine has a pivotal role in nutrient absorption, host defense, and endocrine functions, with the maintenance of its homeostasis relying on the synergistic interplay of intrinsic and extrinsic factors. These encompass a highly ...
Andrew E Hogan,Cian Davis,Benjamin J Jenkins et al.
Andrew E Hogan et al.
Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory phenotype, with each underpinning the other. Over the past decade, new classes of drug, such as glucagon-like peptide-1 (GLP-1)-based therapies and s...
Hui Yang,Shanshan Zhu,Zhe Yang et al.
Hui Yang et al.
Brown adipose tissue (BAT) is a compelling therapeutic target against metabolic diseases. Mechanical cues regulate BAT function and may offer novel, non-pharmacological therapeutic approaches. Herein, we discuss the biomechanical pathways u...
Carlos Matute,Alexei Verkhratsky
Carlos Matute
Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at maintaining brain function upon limited gluc...
Triglyceride-based lipotoxicity in the pathophysiology of chronic diseases [0.03%]
甘油三酯诱导的脂毒性与慢性疾病病理生理学的关系研究进展
Junjun Liu,Xiude Fan,Yongfeng Song et al.
Junjun Liu et al.
Since the introduction of the concept of 'lipotoxicity' 30 years ago, it has become widely accepted that ectopic triglyceride deposition is a key contributor to metabolic diseases. Subsequently, clinical observations have also revealed that...
Exercise pills for cardiometabolic health cannot mimic the exercise milieu [0.03%]
运动药丸不能模仿运动的生理环境以促进心代谢健康
Abel Plaza-Florido,Malene E Lindholm,Pedro Carrera-Bastos et al.
Abel Plaza-Florido et al.
Physical exercise can play an important role both in primary and secondary cardiovascular disease prevention by virtue of its multisystem effects. These beneficial adaptations at the whole-body level include improvements in mitochondrial he...
Noncanonical clock regulators control stress responses in digestive diseases [0.03%]
非经典的时钟调节因子控制消化系统疾病的应激反应
Dishu Zhou,Roberto E López-Valiente,Samer G Mattar et al.
Dishu Zhou et al.
The digestive system is essential for nutrient absorption, processing, and waste elimination. The expression of many genes and physiological processes within this system exhibits a 24-h rhythmicity. However, modern lifestyle factors, such a...
A multidimensional epidemiological perspective on frailty dynamics and prevention [0.03%]
从多维度流行病学视角看衰弱的动态变化及预防措施
Meijie Jiang,Peifeng Guo,Shuzhen Liu et al.
Meijie Jiang et al.
Frailty, characterized by reduced resilience and increased vulnerability, is a growing public health concern in aging populations. It is increasingly recognized as a dynamic and potentially reversible condition, with transitions between non...
Metabolic-immune microenvironment crosstalk mediating ICI resistance in MASH-HCC [0.03%]
代谢免疫微环境互作介导MASH型肝癌ICI耐药机制研究
Yi Ju,Kequan Xu,Xi Chen et al.
Yi Ju et al.
As a pivotal immunotherapy modality, immune checkpoint inhibitors (ICIs) have demonstrated significant clinical efficacy in a variety of malignant tumors, including viral hepatocellular carcinoma (HCC). However, metabolic-associated steatoh...