RcAlb-PepII, a synthetic small peptide bioinspired in the 2S albumin from the seed cake of Ricinus communis, is a potent antimicrobial agent against Klebsiella pneumoniae and Candida parapsilosis [0.03%]
一种新型抗菌肽RcAlb-PepII：蓖麻种子仁中2S清蛋白的片段对肺炎克雷伯氏菌和白念珠菌具有较强的抑菌活性
Lucas P Dias,Pedro F N Souza,Jose T A Oliveira et al.
Lucas P Dias et al.
Antimicrobial peptides (AMPs) are important constituents of the innate immunity system of all living organisms. They participate in the first line of defense against invading pathogens such as viruses, bacteria, and fungi. In view of the in...
Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP [0.03%]
聚集决定膜活性抗癌和抗菌肽的选择性：以killerFLIP为例
Zahra Vaezi,Annalisa Bortolotti,Vincenzo Luca et al.
Zahra Vaezi et al.
Host defense peptides selectively kill bacterial and cancer cells (including those that are drug-resistant) by perturbing the permeability of their membranes, without being significantly toxic to the host. Coulombic interactions between the...
DNA-membrane complex formation during electroporation is DNA size-dependent [0.03%]
电穿孔过程中DNA-膜复合物的形成与DNA大小有关
Shaurya Sachdev,Sara Feijoo Moreira,Yasmine Keehnen et al.
Shaurya Sachdev et al.
Size of DNA molecules governs their interaction with the cell membrane during electroporation and their subsequent transport inside the cell. In order to investigate the effect of DNA size on DNA-membrane interaction during electroporation,...
Molecular dynamics study of membrane permeabilization by wild-type and mutant lytic peptides from the non-enveloped Flock House virus [0.03%]
flock house病毒非包膜裂解肽野生型和突变体介导的细胞膜透化作用的分子动力学研究
Shivangi Nangia,Kevin J Boyd,Eric R May
Shivangi Nangia
Flock House virus (FHV) serves as a model system for understanding infection mechanisms utilized by non-enveloped viruses to transport across cellular membranes. During the infection cycle of FHV, a fundamental stage involves disruption of ...
The influence of cationic lipoid - 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine - on model lipid membranes [0.03%]
阳离子脂类-1-棕榈酰-2-油基-sn-甘油-3-乙基磷胆碱对模型脂质膜的影响
Marzena Mach,Magdalena Kowalska,Karolina Olechowska et al.
Marzena Mach et al.
The triesters of phosphatidylcholine as the derivatives of natural phosphatidylcholines are less cytotoxic than the other cationic lipoids, therefore they can be applied in lipofection and in drug delivery. However, a successful and effecti...
Ionpair-π interactions favor cell penetration of arginine/tryptophan-rich cell-penetrating peptides [0.03%]
离子对-π相互作用促进富含精氨酸/色氨酸的细胞穿透肽的细胞摄取
Astrid Walrant,Antonio Bauzá,Claudia Girardet et al.
Astrid Walrant et al.
Cell-penetrating peptides (CPPs) internalization occurs both by endocytosis and direct translocation through the cell membrane. These different entry routes suggest that molecular partners at the plasma membrane, phospholipids or glycosamin...
Sundar Thangapandian,Karan Kapoor,Emad Tajkhorshid
Sundar Thangapandian
P-glycoprotein (Pgp) is a biomedically important member of the ABC transporter superfamily that mediates multidrug resistance in various cancer types. Substrate binding and transport in Pgp are modulated by the presence of cholesterol in th...
Guillaume Roussel,Stephen H White
Guillaume Roussel
The Escherichia coli SecA ATPase motor protein is essential for secretion of proteins through the SecYEG translocon into the periplasmic space. Its function relies upon interactions with the surrounding lipid bilayer as well as SecYEG trans...
Study on the structure and membrane disruption of the peptide oligomers constructed by hIAPP18-27 peptide and its d,l-alternating isomer [0.03%]
由人IAPP18-27肽及其DL交替异构体构建的寡聚体结构和膜破坏作用研究
Shuang Wang,Feihong Meng,Ruijie Hao et al.
Shuang Wang et al.
Increasing lines of evidence show that the oligomeric intermediates of amyloid peptides/proteins are toxic to biological membranes. However, the structural features of the oligomers that are closely associated with the ability to damage bio...
V K Sharma,E Mamontov,M Tyagi
V K Sharma
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for their antipyretic, anti-inflammatory, and painkiller actions despite a wide spectrum of side effects. The mechanisms involved in their therapeutic actions and side-effe...