Biophysical studies on the antimicrobial activity of linearized esculentin 2EM [0.03%]
线性化苦天竺葵素2em的抗菌活性的生物物理研究
Erum Malik,David A Phoenix,Kamal Badiani et al.
Erum Malik et al.
Linearized esculentin 2 EM (E2EM-lin) from the frog, Glandirana emeljanovi was highly active against Gram-positive bacteria (minimum lethal concentration ≤ 5.0 μM) and strongly α-helical in the presence of lipid mimics of their membranes...
Alexander Krah,Roland G Huber,Ulrich Zachariae et al.
Alexander Krah et al.
Bacteria use a number of mechanisms to defend themselves from antimicrobial drugs. One important defense strategy is the ability to export drugs by multidrug transporters. One class of multidrug transporter, the so-called multidrug and toxi...
Interaction of polyphenols with model membranes: Putative implications to mouthfeel perception [0.03%]
多酚与模型膜的相互作用：可能对口腔感觉感知的影响
Ana Reis,Sónia Soares,Carla F Sousa et al.
Ana Reis et al.
Food polyphenols in fruits juices, tea, coffee, wine and beer confer sensory properties such as colour, astringency and bitterness. The development of functional healthy drinks without the unpleasant sensory feeling is boosting research for...
The orientation of a membrane probe from structural analysis by enhanced Raman scattering [0.03%]
增强拉曼散射的结构分析在膜探针取向中的应用
Hannah J Hughes,Steven M E Demers,Aobo Zhang et al.
Hannah J Hughes et al.
Small fluorescent molecules are widely used as probes of biomembranes. Different probes optically indicate membrane properties such as the lipid phase, thickness, viscosity, and electrical potential. The detailed molecular mechanisms behind...
The role of phospholipid composition and ergosterol presence in the adaptation of fungal membranes to harsh environmental conditions-membrane modeling study [0.03%]
磷脂组成和麦角固醇的存在在真菌膜适应恶劣环境条件中的作用-基于膜的模型研究
Paulina Perczyk,Aneta Wójcik,Paweł Wydro et al.
Paulina Perczyk et al.
Soil fungi play an important role in the environment decomposing dead organic matter and degrading persistent organic pollutants (POP). The presence of hydrophobic POP in the soil and membrane-lytic substances excreted by competing microorg...
Hay Azulay,Aviv Lutaty,Nir Qvit
Hay Azulay
The research fields of proteins and origami have intersected in the study of folding and de-novo design of proteins. However, there is limited knowledge on the analogy between protein structures and origami models. We propose a general appr...
Nobukazu Shitan,Kazufumi Yazaki
Nobukazu Shitan
Vacuole is a prominent organelle that often occupies most of the plant cell volume. The vacuolar accumulation of secondary metabolites, also called specialized metabolites, plays important roles in environmental responses such as protecting...
Alexandra Desrames,Sandrine Genetet,Maëlenn Païline Delcourt et al.
Alexandra Desrames et al.
Over the past few decades, studies on the red blood cell (RBC) membrane gave rise to increasingly sophisticated although divergent models of its structural organization, since investigations were often performed in denaturing conditions usi...
Bacteriocin enterocin CRL35 is a modular peptide that induces non-bilayer states in bacterial model membranes [0.03%]
肠球菌素enterocin CRL35是一种模块化肽，可诱导细菌模型膜的非双层结构状态
Carolina Medina Amado,Carlos J Minahk,Eduardo Cilli et al.
Carolina Medina Amado et al.
The mechanism of action of the anti-Listeria peptide enterocin CRL35 was studied with biophysical tools by using lipid mixtures that mimicked Gram-positive plasma membranes. Langmuir monolayers and infrared spectroscopy indicated that the p...
Substituted cysteine scanning in D1-S6 of the sodium channel hNav1.4 alters kinetics and structural interactions of slow inactivation [0.03%]
在钠通道hNav1.4的D1-S6结构域中替代半胱氨酸扫描改变了慢失活的动力学和结构相互作用
Jonathan M Beard,Penny E Shockett,John P O&#x;Reilly
Jonathan M Beard
Slow inactivation in voltage-gated Na+ channels (Navs) plays an important physiological role in excitable tissues (muscle, heart, nerves) and mutations that disrupt Nav slow inactivation can result in pathophysiologies (myotonia, arrhythmia...