A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression [0.03%]
蛋白质冠抑制脂质体基因表达的机制解释研究
Sara Palchetti,Luca Digiacomo,Francesca Giulimondi et al.
Sara Palchetti et al.
The past three decades have witnessed fast advances in the use of cationic liposome-DNA complexes (lipoplexes) for gene delivery applications. However, no lipoplex formulation has reached into the clinical practice so far. The primary drawb...
Molecular characterization of the outer membrane of Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌外膜的分子特性分析研究进展
Cesar A López,Helen Zgurskaya,S Gnanakaran
Cesar A López
Discovery of new antibiotics effective against Gram-negative bacteria is hampered by the low permeability of the bacterial two-membrane cell envelopes. The outer membrane (OM) is an asymmetric bilayer of lipopolysaccharides (LPS) and phosph...
The boundary lipid around DMPC-spanning influenza A M2 transmembrane domain channels: Its structure and potential for drug accommodation [0.03%]
环绕DMPC跨膜的流感A M2通道周围的边界脂质：其结构及药物结合位点的潜力
Athina Konstantinidi,Maria Chountoulesi,Nikolaos Naziris et al.
Athina Konstantinidi et al.
We have investigated the perturbation of influenza A M2TM in DMPC bilayers. We have shown that (a) DSC and SAXS detect changes in membrane organization caused by small changes (micromolar) in M2TM or aminoadamantane concentration and aminoa...
Effect of dipole moment on amphiphile solubility and partition into liquid ordered and liquid disordered phases in lipid bilayers [0.03%]
偶极矩对两亲分子在脂质双层中的溶解度及有序相与无序相分配行为的影响
Renato M S Cardoso,Patrícia A T Martins,Cristiana V Ramos et al.
Renato M S Cardoso et al.
Association of amphiphiles with biomembranes is important for their availability at specific locations in organisms and cells, being critical for their biological function. A prominent role is usually attributed to the hydrophobic effect, a...
Modulation of Orai1 by cationic peptides triggers their direct cytosolic uptake [0.03%]
阳离子肽通过调节Orai1诱导其直接胞质摄取
Cristiane R Zuconelli,Samuel Schmidt,Rike Wallbrecher et al.
Cristiane R Zuconelli et al.
At concentrations exceeding 10 μM, arginine-rich cell-penetrating peptides (CPPs) trigger a rapid cytoplasmic import that involves activation of acid sphingomyelinase (ASMase). ASMase activation occurs through a variety of stress signals a...
Detergent-free extraction of a functional low-expressing GPCR from a human cell line [0.03%]
无需洗涤剂的人类细胞系功能型低表达GPCR提取
Juan Francisco Bada Juarez,Juan C Muñoz-García,Rosana Inácio Dos Reis et al.
Juan Francisco Bada Juarez et al.
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regul...
Exploring the role of the membrane bilayer in the recognition of candesartan by its GPCR AT1 receptor [0.03%]
探讨双层膜在坎地沙坦与其GPCR AT1受体识别中所起的作用
Sofia Kiriakidi,Christos Chatzigiannis,Christina Papaemmanouil et al.
Sofia Kiriakidi et al.
Cardiovascular diseases and hypertension in particular are major health risks worldwide and the improvement on their treatment will be beneficial for the human health. AT1R antagonists belong to the sartans family that targets the renin-ang...
Bacterial lipopolysaccharide core structures mediate effects of butanol ingress [0.03%]
丁醇的渗入效应由细菌脂多糖核心结构介导
Jingjing Guo,Geraldine W N Chia,Nikolay V Berezhnoy et al.
Jingjing Guo et al.
The outer membrane (OM) is the first defence for Gram-negative bacteria against their environments making it important in strain improvement for sustainable biobutanol production. While modifying the OM structure using chemical additives co...
The membrane protein KCNQ1 potassium ion channel: Functional diversity and current structural insights [0.03%]
膜蛋白KCNQ1钾通道：功能多样性及结构研究进展
Gunjan Dixit,Carole Dabney-Smith,Gary A Lorigan
Gunjan Dixit
Background: Ion channels play crucial roles in cellular biology, physiology, and communication including sensory perception. Voltage-gated potassium (Kv) channels execute their function by sensor activation, pore-coupling...
Miroslav Jurásek,Klas Flärdh,Robert Vácha
Miroslav Jurásek
DivIVA is a crucial membrane-binding protein that helps to localize other proteins to negatively curved membranes at cellular poles and division septa in Gram-positive bacteria. The N-terminal domain of DivIVA is responsible for membrane bi...