Immune antibodies recognizing the stem region of SARS-CoV-2 spike protein: Molecular modeling and in vitro study of synthetic peptides presentation to the antibodies [0.03%]
针对SARS-CoV-2刺突蛋白茎部区域的免疫抗体：合成肽段与抗体结合的分子模拟和体外研究
Elena T Aliper,Ivan M Ryzhov,Polina S Obukhova et al.
Elena T Aliper et al.
Antibodies to peptide 1147 (amino acids 1147-61) of the SARS-CoV-2 S protein are highly diagnostic. Peptide 1147, although located in a region that is partly spatially hidden in the intact protein, is not subject to mutations, suggesting th...
The relationship between the structural transitions of DMPG membranes and the melting process, and their interaction with water [0.03%]
DMPG膜的结构转变及其与熔化过程的关系和与水的作用力之间的相互作用关系研究
Thomas Heimburg,Holger Ebel,Peter Grabitz et al.
Thomas Heimburg et al.
During the melting transition of dimyristoyl phosphatidylglycerol (DMPG), the order of the lipid chains and the three-dimensional, vesicular structural arrangement change simultaneously. These changes result in peculiar heat capacity profil...
MPP1 controls lipid domain remodelling in giant vesicles containing reconstituted flotillins [0.03%]
含有重构的flotillin的大囊泡中的液滴域重塑由MPP1控制
Agnieszka Chytła,Agnieszka Biernatowska,Weronika Gajdzik-Nowak et al.
Agnieszka Chytła et al.
Membrane palmitoylated protein 1 (MPP1), a protein found to directly interact with flotillins, has been shown to play a crucial role as a raft-capturing molecule, modulating dynamics of flotillin-nanodomains and affects plasma membrane (PM)...
Lateral lipid packing governs bilayer solubilization by styrene-maleic acid copolymers: a case study with cardiolipin-containing membranes [0.03%]
侧向脂质排列决定苯乙烯-马来酸共聚物对双层溶解的作用：含心磷脂膜的案例研究
Joseph C Iovine,Benjamin T Garrett,Nathan N Alder
Joseph C Iovine
Styrene-maleic acid (SMA) copolymers are powerful tools for the detergent-free solubilization of biological membranes. Yet the influence of specific lipids on SMA activity remains an open question. Here, we examined the effects of the mitoc...
Temperature, pressure and salt effects on bilayers of an acidic phospholipid, dipalmitoylphosphatidylglycerol [0.03%]
温度、压力和盐对酸性磷脂二棕榈酰卵磷脂甘油的双层的影响
Masaki Goto,Saeko Tanaka,Nobutake Tamai et al.
Masaki Goto et al.
The effects of thermal pretreatments and a monovalent added salt (NaCl) on the thermotropic and barotropic bilayer phase behavior of an acidic phospholipid, dipalmitoylphosphatidylglycerol (DPPG), were investigated by differential scanning ...
Unveiling the impact of membrane fluidity in shaping lipid-based drug delivery systems development [0.03%]
揭示膜流动性在塑造脂质基药物递送系统开发中的影响
Mariana Biscaia-Caleiras,Ana Sofia Lourenço,João Nuno Moreira et al.
Mariana Biscaia-Caleiras et al.
Membrane fluidity is a fundamental property extensively studied in biological membranes and biophysical research, where it is critical to understanding membrane structure and function. However, its application in the development and manufac...
Transmembrane channel-like 4 (TMC4) could act as a negative regulator of KCNQ1 (Kv7.1) potassium channel [0.03%]
跨膜通道样4(TMC4)可能是KCNQ1(Kv7.1)钾通道的负调控因子
Hirota Aoyagi,Koya Kawaguchi,Saori Yano-Nashimoto et al.
Hirota Aoyagi et al.
TMC4 is a member of the transmembrane channel-like (TMC) protein family. In this family, TMC1 and TMC2 are thought to form the mechano-electrical transduction (MET) channel in the inner ear. On the other hand, the intrinsic functions of the...
Brandon S Veron,Kyle Lethcoe,Robert O Ryan
Brandon S Veron
The SpyCatcher/SpyTag system represents a unique technology that allows facile conjugation of proteins via formation of a covalent isopeptide bond between the 113 residue SpyCatcher protein and a 16 residue SpyTag peptide. Herein this techn...
Small angle neutron scattering study of rhodopsin oligomerization and G-protein coupling in a physiologically relevant lipid membrane [0.03%]
生理相关脂质膜中视紫红质寡聚化及与G蛋白偶联的小角中子散射研究
Olivier Soubias,Jonathan D Nickels,Kirk G Hines et al.
Olivier Soubias et al.
Although the oligomeric states of G-protein-coupled receptors (GPCRs) and interactions with cognate G proteins are central to their signal transduction capabilities, they remain poorly defined. In this study, we used small-angle neutron sca...
Mark J Arcario,Vikram Dalal,David Fan et al.
Mark J Arcario et al.
Nanodiscs, soluble membrane mimetics composed of an amphipathic membrane scaffold protein encircling a lipid bilayer, are widely used in biophysical and structural studies of membrane proteins. Because many membrane proteins are responsive ...