Investigating the electrostatics underlying activation of the β2 adrenergic receptor [0.03%]
探究β₂肾上腺素受体激活的电荷效应
Julia M Montgomery,Justin A Lemkul
Julia M Montgomery
G-protein coupled receptors (GPCRs) are the largest family of membrane proteins in humans and represent critical targets for drug discovery efforts. Among GPCRs, the β-2 adrenergic receptor (β2AR) has served as a prototypical example of t...
Small rubber particle protein 1 of Hevea brasiliensis exhibits biophysical characteristics similar to apolipoproteins [0.03%]
海芙蓉小橡胶颗粒蛋白1表现出与载脂蛋白相似的生物物理特性
Christie Howard,Paul M M Weers,Robert O Ryan et al.
Christie Howard et al.
Plants produce natural rubber in specialized organelles, termed rubber particles (RP). The structure of the RP consists of a polyisoprene (rubber) core surrounded by a shell layer composed of a lipid monolayer and proteins. Among the promin...
A Roldán,P Fernández-García,V Lladó et al.
A Roldán et al.
Antimicrobial peptides (AMPs) represent a current strategy to develop new antibiotics against multi-resistant pathogens. The potential antibiotic activity of AMPs is related to their amphipathic properties and the presence of positively cha...
Mechanistic insight into the role of lipoglycopeptide drugs in hepatotoxicity [0.03%]
脂糖肽药物肝毒性的机制研究见解
Akash Kumar Jha,Vetriselvan Subramaniyan,Raj Gupta et al.
Akash Kumar Jha et al.
Understanding how antibiotics interact with membranes is crucial for predicting their off-target effects, particularly hepatotoxicity. This work compares two clinically important glycopeptide antibiotics, Teicoplanin and Oritavancin, using ...
Nanoscopic remodeling of lipid bilayers by cell-penetrating peptide penetratin [0.03%]
细胞穿透肽penetratin对脂质双层的纳米级重塑作用
Yasith Indigahawela Gamage,Jianjun Pan
Yasith Indigahawela Gamage
Cell-penetrating peptides (CPPs) such as penetratin are known to traverse lipid membranes, yet the nanoscale structural consequences of their membrane interactions remain incompletely understood. Using atomic force microscopy (AFM), we visu...
Structural and dynamics of apoA-1 mimetic peptide lipid nanodisc assemblies: A molecular dynamics study [0.03%]
一种模拟apoA-1肽的脂质纳米盘组件的结构和动力学研究——基于分子动力学方法
Rohith Ravi,Evgeniy S Salnikov,Burkhard Bechinger et al.
Rohith Ravi et al.
Apolipoprotein A-I (apoA-I) mimetic peptides, inspired by the principal protein component of high-density lipoprotein, self-assemble with lipids to form discoidal nanodiscs widely used in biomedical research and as versatile scaffolds for c...
Acylation of the RTX toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol [0.03%]
MbxA RTX 毒素的酰基化通过特异性结合胆固醇来刺激宿主细胞膜破裂
Feby Mariam Chacko,Sarah Michelle Ganz,Anne Pfitzer-Bilsing et al.
Feby Mariam Chacko et al.
RTX toxins (Repeat in ToXins) are pore-forming toxins secreted by gram-negative bacteria. They are known for their ability to disrupt host cell membranes, among which various human cells. The acylation of specific lysine residues in these t...
Nidhi Sorout,Volkhard Helms
Nidhi Sorout
The integral membrane pore Sec61 catalyzes the translocation of many secretory precursor proteins into the endoplasmic reticulum, as well as the insertion of transmembrane proteins into the cell and organellar membranes. Precursor proteins ...
Effect of amyloid-beta 1-40 and 1-42 peptides on the lateral diffusion and signaling of receptor for advanced glycation endproducts (RAGE) [0.03%]
Αβ肽对晚期糖基化终产物受体（RAGE）横向扩散及信号转导的影响研究
Chamari S Wijesooriya,Sharifur Rahman,Emily A Smith
Chamari S Wijesooriya
The receptor for advanced glycation endproducts (RAGE) is a pattern recognition receptor that interacts with different ligands, including the amyloid-beta (Aβ) peptides, to initiate signaling pathways and creates pro-inflammatory mediators...
Emad Ghazizadeh,Mahdi Zeidi,Wylie Stroberg
Emad Ghazizadeh
The endoplasmic reticulum (ER) is a highly dynamic organelle that undergoes continuous remodeling between tubular and sheet-like structures, driven by curvature-inducing proteins and membrane mechanics. Understanding the physical principles...