Investigation of biophysical properties of ion channels with nonlinear methods [0.03%]
采用非线性方法研究离子通道的生物物理性质
Mahmut Akilli,Fatma Söğüt,Ülkü Çömelrkoğlu et al.
Mahmut Akilli et al.
The aim of this study is to show how nonlinear methods can be used to investigate the biophysical properties of ion channels. For this purpose, the membrane ion current signals of the EAG1 potassium channel of MCF-7 cells and of the TRP cha...
The phospholipolytically active neurotoxin Vipoxin induces changes of the mechanical properties of breast epithelial cells [0.03%]
具磷脂酶活性的神经毒素Vipoxin可诱导乳腺上皮细胞机械性质发生变化
Will Linthicum,Qi Wen,Nancy A Burnham et al.
Will Linthicum et al.
The investigation of how drugs or toxins alter cell mechanics is gaining significant traction in biomedical science, driven by the dual objectives of elucidating their mechanisms of action and enhancing drug screening processes. In this stu...
An advanced spectroscopic and crystallographic study on a synergistic composition of a 1,3,4-thiadiazole derivative and amphotericin B, in model biological liposomal system [0.03%]
一种1,3,4-噻二唑衍生物与两性霉素B在模型生物脂质体系统中的协同作用研究：光谱及晶体学研究表明
Lidia Ślusarczyk,Klaudia Rząd,Daniel Kamiński et al.
Lidia Ślusarczyk et al.
The paper presents the results of the first spectroscopic, microcalorimetric, and crystallographic study analyzing in great detail the strongly synergistic composition containing a selected 1,3,4-thiadiazole derivative: 4-(5-methyl-1,3,4-th...
Amino acids critical for lipid/s-interaction at the lipid-water-interface of TRPV5/TRPV6 remain different during vertebrate radiation: Relevance in cancer, bone disorders and other pathophysiologies [0.03%]
氨基酸在TRPV5/6脂质/界面的脂质-水相互作用中至关重要：癌症、骨病和其他病理生理的相关性
Sweta Agarwal,Vikash Kumar,Anupriya Chattapadhya et al.
Sweta Agarwal et al.
TRPV5 and TRPV6 are members of the TRP superfamily of ion channels and are present in almost all vertebrates as linked-genes with high homology and functional similarities. Abnormalities in the regulation or function of these two channels c...
Membrane properties control the ATPase activity of the ABC transporter BmrA [0.03%]
膜性质控制ABC转运蛋白BmrA的ATP酶活性
Veronika Osten,Dirk Schneider
Veronika Osten
The structure and the function of membrane proteins can be affected by the lipid bilayer environment, yet its impact is often neglected in in vitro studies where proteins are typically analyzed in membrane mimetics, mostly liposomal systems...
Interaction of lensoside Aβ with lipids and proteins of HeLa cells [0.03%]
lensoside Aβ与HeLa细胞脂质和蛋白质的相互作用
Justyna Kapral-Piotrowska,Agata Wawrzyniak,Jarosław Pawelec et al.
Justyna Kapral-Piotrowska et al.
Lensoside Aβ (LAβ) is a quercetin derivative isolated from the leaves and stems of the Lens culinaris cultivar Tina. Flavonoid-membrane interactions are crucial for their physiological and pharmacological activity. We have demonstrated th...
Crotalicidin and NA-CATH-ATRA-1-ATRA-1 peptide-induced membrane disruption in human breast cancer cells [0.03%]
铜头蛇肽和NA-CATH-ATRA-1-ATRA-1多肽诱导的人乳腺癌细胞膜损伤研究
Vanessa Gallego-Londoño,Gloria A Santa-González,Juan M Giraldo-Lorza et al.
Vanessa Gallego-Londoño et al.
Cationic peptides offer a promising alternative for cancer treatment due to their ability to target cancer cells via standard membrane features, thereby overcoming intratumoral heterogeneity. This study investigates the cytotoxic activity a...
Acidic bicelles are a suitable membrane mimic for structural studies of the Lassa virus fusion domain [0.03%]
酸性双胶粒适合作拉沙病毒融合区结构研究的膜模型
Hallie N Pennington,Jinwoo Lee
Hallie N Pennington
Lassa virus (LASV) is the most prevalent arenavirus afflicting humans and has high pandemic potential. The genetic material of LASV is delivered into the host cell via membrane fusion initiated by the LASV fusion domain (FD). However, the m...
Effect of membrane tension on (-)-epigallocatechin gallate-induced burst of single giant unilamellar vesicles [0.03%]
膜张力对(-)-表没食子儿茶素没食子酸酯诱导的单个大单层囊泡爆发的影响
Yukihiro Tamba,Naoya Sugita,Mika Terada et al.
Yukihiro Tamba et al.
(-)-Epigallocatechin gallate (EGCg), a tea catechin, exhibits antimicrobial activity. EGCg induces burst of giant unilamellar vesicles (GUVs), resulting in leakage of their internal contents. Here, we examined the effect of membrane tension...
Amyloid-liposome composites as hybrid platforms for doxorubicin delivery [0.03%]
用于紫杉醇输送的淀粉样蛋白-脂质体复合杂交平台
Valeriya Trusova,Uliana Malovytsia,Kateryna Vus et al.
Valeriya Trusova et al.
The feasibility of engineering the sophisticated hybrid drug delivery platforms through the integration of phospholipid vesicles within a matrix of amyloid suspensions has been evaluated. Utilizing the equilibrium dialysis methodology and s...