Modulation of TNAP activity and apatite formation in biomimetic matrix vesicles studied by 31P solid-state NMR [0.03%]
31P固态NMR研究仿生基质囊泡中的TNAP活性及羟基磷灰石形成
B Z Favarin,N Nassif,T Azaïs et al.
B Z Favarin et al.
Skeletal and dental mineralization relies on a precisely regulated sequence of events culminating in apatite deposition onto collagen fibrils. Matrix vesicles (MVs), extracellular vesicles released by mineralization-competent cells, play a ...
Complexes of star-shaped block copolymers of poly(2-alkyl-2-oxazine)s and curcumin can affect lipid bilayers mimicking biomembranes [0.03%]
星形嵌段共聚物和姜黄素的复合物可以影响仿生膜脂质双层
Svetlana S Efimova,Vera A Martynyuk,Nina D Kozina et al.
Svetlana S Efimova et al.
Poly(2-alkyl-2-oxazine)s (PAlOz) are promising tools for developing delivery systems due to their high biocompatibility, resistance to enzyme hydrolysis, and ability to degrade in biological environments. Here, we investigated the effects o...
Study on the correlation between proton transfer of phenolic hydroxyl groups of 6 flavonoid compounds and their antioxidant activities [0.03%]
6种黄酮类化合物苯酚羟基质子转移与其抗氧化活性相关性研究
Gong Shuangmei,Yang Changying,Li Min et al.
Gong Shuangmei et al.
This study investigated six flavonoids' photophysical properties in various environments, revealing their pKa variations (e.g., quercetin: 7.364 in water vs 9.329 in vesicles) and demonstrating vesicle/liposome systems' protective effects b...
Assessing the anticancer potential of spider venom peptide Latarcin Ltc2a against triple negative breast cancer [0.03%]
评估狼蛛毒肽Latarcin Ltc2a对三阴性乳腺癌的抗癌潜力
Prasanjeet Kaur,Srabaita Roy,Shilpi Minocha et al.
Prasanjeet Kaur et al.
Cancer remains one of the most formidable challenges to human health, necessitating constant exploration of innovative therapeutic strategies. Among the myriad potential candidates, peptides from venom have emerged as potent sources of bioa...
The coronavirus spike HR2 domain: An obscure player entering the limelight during membrane fusion? [0.03%]
冠状病毒刺突蛋白HR2区：在膜融合过程中鲜为人知的登场者？
Elena T Aliper,Roman G Efremov
Elena T Aliper
The coronavirus spike protein, the key entity effectuating membrane fusion, cannot exist without membrane-active fragments. In addition to fusion peptides, among such domains are HR1 and HR2. Crucial to the spike's refolding and membrane fu...
Accurate antibiotic accumulation in Enterobacteriaceae isolates expressing efflux pumps [0.03%]
表达外排泵的肠杆菌科分离株的抗生素累积准确性
Jinane Tabcheh,Julia Vergalli,Jean-Marie Pagès et al.
Jinane Tabcheh et al.
In Enterobacteriaceae, antibiotic susceptibility is frequently influenced by mechanisms such as membrane modifications, target site mutations, and enzymatic resistance barriers. Recently, there has been a notable rise in Klebsiella pneumoni...
Development of amyloid-cationic peptides with antimicrobial activities: Relation to their membranotropic activities [0.03%]
兼具抗菌活性和膜活性的淀粉样-阳离子肽类的研发
Marta Balestra,Lilia Leghmizi,Thierry Drujon et al.
Marta Balestra et al.
We describe here a new class of antimicrobial peptides (named Amy-Cat) comprised of a short amyloid domain and a cationic domain, as a primary amphipathic structure. The nona-arginine sequence was chosen as the cationic motif, while the seq...
Two phase coexistence in ternary mixtures of saturated and polyunsaturated phosphatidylcholines with cholesterol [0.03%]
饱和及多不饱和磷脂与胆固醇三元混合物中的二相共存现象
James H Davis
James H Davis
Combining 2H and 14N nuclear magnetic resonance measurements on ternary lipid/cholesterol mixtures it is possible to quantitate the phase separation into coexisting ℓo and ℓd domains using a single sample whose composition is within the t...
Rescue of sirtuin inhibitor-dependent decrease in claudin-4 expression and paracellular barrier property in keratinocytes by epigallocatechin gallate [0.03%]
儿茶素通过表皮细胞核内受体作用逆转多酚类sirtn抑制剂所导致的紧密连接 Claudin-4表达缺失及通透性屏障功能受损现象
Maika Miwa,Miki Tanabe,Shunsuke Matsuda et al.
Maika Miwa et al.
The barrier function of granular layer in the skin is mainly sustained by claudin-1 (CLDN1) and CLDN4, tight junctional components. We recently found that the activity of sirtuin-2 (SIRT2), an anti-aging molecule, is decreased with aging in...
Novel flavonoid-magnesium complexes as inhibitors of plasma membrane calcium ATPase [0.03%]
一种新的黄酮-镁复合物类质膜钙依赖性胞苷三磷酸酶抑制剂
Mallku Q Ontiveros,Mariel Marder,Rolando C Rossi et al.
Mallku Q Ontiveros et al.
Plasma membrane calcium ATPases (PMCAs) are essential for regulating intracellular calcium (Ca2+) levels by extruding it from the cytosol. Improper regulation of these transporters is associated with numerous diseases, including neurologica...