Targeting prokaryotic ion channel by a chimera of fluorescent protein and artificial peptide toxin [0.03%]
荧光蛋白和人工肽毒素嵌合体作用于古细菌离子通道
Valentina A Iunusova,Nikita A Orlov,Oksana V Nekrasova et al.
Valentina A Iunusova et al.
KcsA, a potassium channel from Streptomyces lividans, is one of the most extensively studied transmembrane proteins. Despite significant research in structural biology, relatively few ligands of KcsA have been identified. One such ligand is...
Improving chemical synthesis and the antimicrobial activity of human defensins through disulfide bond engineering of HBD-3 [0.03%]
通过半胱氨酸残基定点突变及人工二硫键的引入改造人源性宿主防御蛋白HBD-3抗氧化性能及其抗菌活性
Aleksandra Walewska,Paulina Kosikowska-Adamus,Anna Wardowska et al.
Aleksandra Walewska et al.
Human β-defensins are disulfide-rich peptides that exhibit broad-spectrum antimicrobial activity against bacteria, fungi, and certain viruses, while also exerting immunomodulatory effects. As naturally occurring host defense peptides in th...
Steady dimer formation by the S31N mutant of influenza A virus M2 protein in living cell membranes [0.03%]
流感A病毒M2蛋白S31N突变体在活细胞膜上形成稳定的二聚体
Kenichi Kawano,Tyuji Hoshino,Yoshiaki Yano et al.
Kenichi Kawano et al.
The integral matrix protein M2 of the influenza A virus (H3N2) has been proposed to form a proton-selective channel, and is a target of the antiviral drug amantadine hydrochloride (Am). A significant increase in the number of drug-resistant...
SARS-CoV E protein couples asymmetric leaflet thickness and curvature deformations [0.03%]
SARS-CoV E蛋白连接不对称叶片厚度和曲率变形
Jesse W Sandberg,Grace Brannigan
Jesse W Sandberg
The Envelope protein (E protein) of SARS-CoVs 1 and 2 has been implicated in the viral budding process and maintaining the spherical shape of the virus, but direct evidence linking the protein to long-range membrane deformation is still lac...
Peter M Macdonald
Peter M Macdonald
In 1987 Seelig and colleagues proposed that the phosphocholine headgroup of phosphatidylcholine behaved as a universal sensor of surface electrostatic charge, both cationic and anionic, in lipid bilayers (J. Seelig, P.M. Macdonald, P.G. Sch...
Evaluation of the effects of bovine lactoferrin on the membrane of human erythrocytes [0.03%]
牛乳铁蛋白对人红细胞膜影响的评价
Leilismara Sousa Nogueira,Bárbara Martins Cordeiro,Gilvânia Aparecida Rabelo Cordeiro et al.
Leilismara Sousa Nogueira et al.
Lactoferrin (Lf) is an iron-binding glycoprotein involved in various biological functions, including iron metabolism and immune response. Bovine lactoferrin (bLf) has gained attention due to its potential therapeutic applications. This stud...
Daptomycin membrane activity is modulated by the localized interplay between calcium ions and phospholipids in monolayers and bilayers containing a lysyl-phosphatidylglycerol analogue [0.03%]
钙离子和磷脂在含有赖氨磷脂酸甘油的单层和双层膜中对达托霉素膜活性的局部调节作用
Maria Hoernke,Shuai Shi,Alasdair T M Hubbard et al.
Maria Hoernke et al.
Using the stable synthetic analogue 3-aza-dehydroxylysyl-phosphatidylglycerol (3adLPG), the putative role of native staphylococcal LPG in inhibiting the antibiotic daptomycin from binding to its target phosphatidylglycerol (PG), was investi...
Antileishmanial, cytotoxic activities, and membrane rigidity effects of three synthetic compounds [0.03%]
三种合成化合物的抗利什曼病、细胞毒性作用及膜僵硬效应
Éder Jéferson Souza Cardoso,Ellyêssa Nascimento Borges,Kleber Santiago Freitas E Silva et al.
Éder Jéferson Souza Cardoso et al.
Three antileishmanial compounds incorporating a butylated hydroxytoluene (BHT) moiety and an acrylate-based Michael acceptor scaffold were rationally designed from the lead structures LQFM064 and LQFM332, which feature a chalcone-derived co...
Estelle Morvan,Axelle Grélard,Erick J Dufourc
Estelle Morvan
Following the publication of biological membrane models in the 1970s, Joachim Seelig was the first to experimentally demonstrate the dynamic nature of these membranes. He conducted the first ssNMR experiments to measure the order parameters...
Biophysical investigations of the membrane interactions of collagen VI-derived host defense peptides [0.03%]
来源于VI型胶原的宿主防御肽与细胞膜相互作用的生物物理研究
Kathakali De,Karin Bryder,Christopher Aisenbrey et al.
Kathakali De et al.
Collagen VI is an extracellular matrix protein forming complex microfibrillar networks in connective tissues. Specifically, we focused on its role in innate immunity, in particular on cationic sequence motifs from the α3(VI)-chain, which e...