Development, activation, and therapeutic potential of thermogenic adipocytes [0.03%]
生热脂肪细胞的发育、激活和治疗潜力
Margo P Emont,Dong-Il Kim,Jun Wu
Margo P Emont
During the last decade, significant progress has been made in understanding adipocytes with a particular focus on thermogenic fat cells, which effectively convert chemical energy into heat in addition to their other metabolic functions. It ...
Deborah Goody,Alexander Pfeifer
Deborah Goody
Brown adipose tissue (BAT) dissipates energy as heat and its activity correlates with leanness in human adults. Understanding the mechanisms behind the activation of BAT and the process of "browning", i.e. the appearance of inducible brown ...
Olga Gulyaeva,Jon Dempersmier,Hei Sook Sul
Olga Gulyaeva
White adipose tissue (WAT) is the primary energy storage organ and its excess contributes to obesity, while brown adipose tissue (BAT) and inducible thermogenic (beige/brite) adipocytes in WAT dissipate energy via Ucp1 to maintain body temp...
Revati S Dewal,Kristin I Stanford
Revati S Dewal
Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adi...
Adaptive thermogenesis by dietary n-3 polyunsaturated fatty acids: Emerging evidence and mechanisms [0.03%]
膳食n-3多不饱和脂肪酸介导的生热适应：新兴证据与机制研究进展
Rong Fan,Karsten Koehler,Soonkyu Chung
Rong Fan
Brown/beige fat plays a crucial role in maintaining energy homeostasis through non-shivering thermogenesis in response to cold temperature and excess nutrition (adaptive thermogenesis). Although numerous molecular and genetic regulators hav...
OTUD7B controls oxLDL uptake by stabilizing Lox-1 in THP-1 and U937 cells [0.03%]
OTUD7B通过稳定Lox-1控制THP-1和U937细胞摄取氧化型低密度脂蛋白(oxLDL)
Background: The scavenger receptor Lox-1 plays a crucial role in mediating the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages, thereby promoting foam cell formation and the development of atherosclerosi...
Decoding the excited-state dynamics of carbonyl-containing carotenoids: Insights from the Ind series [0.03%]
含羰基类胡萝卜素激发态动力学的解码：Ind 系列的见解
Carotenoids are naturally occurring pigments essential for both light-harvesting and photoprotection in photosynthetic processes. Among these, carbonyl-containing carotenoids exhibit distinctive excited state properties due to the presence ...