Q Raas,F-E Saih,C Gondcaille et al.
Q Raas et al.
Acyl-CoA oxidase 1 (ACOX1) deficiency is a rare and severe peroxisomal leukodystrophy associated with a very long-chain fatty acid (VLCFA) β-oxidation defect. This neurodegenerative disease lacks relevant cell models to further decipher th...
Harmful and protective roles of group V phospholipase A2: Current perspectives and future directions [0.03%]
组V磷脂酶A2的有害和保护作用：当前观点与未来方向
Sachin K Samuchiwal,Barbara Balestrieri
Sachin K Samuchiwal
Group V Phospholipase A2 (Pla2g5) is a member of the PLA2 family of lipid-generating enzymes. It is expressed in immune and non-immune cell types and is inducible during several pathologic conditions serving context-specific functions. In t...
Xiao-Man Sun,Lu-Jing Ren,Quan-Yu Zhao et al.
Xiao-Man Sun et al.
Microalgal lipids have drawn great attention as a promising sustainable resource for biodiesel or food supplement production. The development of high-performance strains of microalgae by metabolic engineering is invaluable for increasing th...
Effects of anticoagulants and storage conditions on clinical oxylipid levels in human plasma [0.03%]
抗凝剂和储存条件对人类血浆临床氧化脂质水平的影响
Hulda S Jonasdottir,Hilde Brouwers,René E M Toes et al.
Hulda S Jonasdottir et al.
Metabolomics and lipidomics are of fundamental importance to personalized healthcare. Particularly the analysis of bioactive lipids is of relevance to a better understanding of various diseases. Within clinical routines, blood derived sampl...
FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism [0.03%]
FTO通过m6A-YTHDF2依赖机制控制细胞周期进程来调节脂肪细胞生成
Ruifan Wu,Youhua Liu,Yongxi Yao et al.
Ruifan Wu et al.
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes. Loss of m6A demethylase FTO increases m6A levels and inhibits adipogenesis of preadipocytes. However, its underlying mechanism remains elusive. Here, w...
Plant hydroperoxide-cleaving enzymes (CYP74 family) function as hemiacetal synthases: Structural proof of hemiacetals by NMR spectroscopy [0.03%]
植物环氧合酶(CYP74族)可作为半缩醛醇合成酶：通过核磁共振光谱技术证实半缩醛醇结构
Lucia S Mukhtarova,Fredi Brühlmann,Mats Hamberg et al.
Lucia S Mukhtarova et al.
Hydroperoxide lyases (HPLs) of the CYP74 family (P450 superfamily) are widely distributed enzymes in higher plants and are responsible for the stress-initiated accumulation of short-chain aldehydes. Fatty acid hydroperoxides serve as substr...
Extended-resolution imaging of the interaction of lipid droplets and mitochondria [0.03%]
脂滴和线粒体相互作用的延拓分辨率成像技术
Maria Pribasnig,Benedikt Kien,Lisa Pusch et al.
Maria Pribasnig et al.
Physical contacts between organelles play a pivotal role in intracellular trafficking of metabolites. Monitoring organelle interactions in living cells using fluorescence microscopy is a powerful approach to functionally assess these cellul...
Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet [0.03%]
补给植物固醇能改善高脂饮食诱导的非酒精性脂肪肝及其血脂异常
Simin Feng,Zhuqing Dai,Anna B Liu et al.
Simin Feng et al.
Objective: To investigate and compare the effects of two common dietary phytosterols, stigmasterol and β-sitosterol, in altering lipid metabolism and attenuating nonalcoholic fatty liver disease (NAFLD). ...
A critical appraisal of the measurement of serum 'cholesterol efflux capacity' and its use as surrogate marker of risk of cardiovascular disease [0.03%]
关于血清“胆固醇流出能力”测定及其作为心血管疾病风险替代标志物使用的批判性评价
Malcolm Anastasius,Celine Luquain-Costaz,Maaike Kockx et al.
Malcolm Anastasius et al.
The 'cholesterol efflux capacity (CEC)' assay is a simple in vitro measure of the capacities of individual sera to promote the first step of the reverse cholesterol transport pathway, the delivery of cellular cholesterol to plasma HDL. This...
Spexin: A novel regulator of adipogenesis and fat tissue metabolism [0.03%]
新型脂肪细胞生成和脂肪组织代谢调节因子Spexin
Pawel A Kolodziejski,Ewa Pruszynska-Oszmalek,Maciej Micker et al.
Pawel A Kolodziejski et al.
Spexin (SPX, NPQ) is a novel peptide involved in the regulation of energy metabolism. SPX inhibits food intake and reduces body weight. In obese humans, SPX is the most down-regulated gene in fat. Therefore, SPX might be involved in the reg...