Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma [0.03%]
来自Cyp27a1基因敲除小鼠脑和血浆分析的胆固醇代谢额外途径的证据
William J Griffiths,Peter J Crick,Anna Meljon et al.
William J Griffiths et al.
Cytochrome P450 (CYP) 27A1 is a key enzyme in both the acidic and neutral pathways of bile acid biosynthesis accepting cholesterol and ring-hydroxylated sterols as substrates introducing a (25R)26-hydroxy and ultimately a (25R)26-acid group...
Thermogenic fat [0.03%]
产热脂肪组织
Sarah J Marx,Paul Cohen
Sarah J Marx
Channeling of newly synthesized fatty acids to cholesterol esterification limits triglyceride synthesis in SND1-overexpressing hepatoma cells [0.03%]
新生脂肪酸向胆固醇酯化途径的转移限制了SND1过表达肝癌细胞中的三酰甘油合成
Hiart Navarro-Imaz,Yolanda Chico,Yuri Rueda et al.
Hiart Navarro-Imaz et al.
SND1 is a putative oncoprotein whose molecular function remains unclear. Its overexpression in hepatocellular carcinoma impairs cholesterol homeostasis due to the altered activation of the sterol regulatory element-binding protein (SREBP) 2...
Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway [0.03%]
母体二十碳五烯酸喂养通过Sirtuin-1非依赖性炎症途径促进胎盘血管生成
Jie Peng,Yuanfei Zhou,Zhang Hong et al.
Jie Peng et al.
Maternal overnutrition or obesity is associated with a wide range of metabolic disorders and may impair placental angiogenesis. Previous studies have shown that n-3 polyunsaturated fatty acids (PUFA) promote fetal growth in both rodents and...
Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis [0.03%]
基于高通量定量图像分析的酵母中控制脂滴大小基因产物鉴定研究
Xuchao Lv,Jiaming Liu,Yiran Qin et al.
Xuchao Lv et al.
Lipid droplets (LDs) are important organelles involved in energy storage and expenditure. LD dynamics has been investigated using genome-wide image screening methods in yeast and other model organisms. For most studies, genes were identifie...
iPLA2β and its role in male fertility, neurological disorders, metabolic disorders, and inflammation [0.03%]
group iia磷脂酶a2在男性生育、神经障碍、代谢紊乱和炎症中的作用研究
John Turk,Tayleur D White,Alexander J Nelson et al.
John Turk et al.
The Ca2+-independent phospholipases, designated as group VI iPLA2s, also referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and η forms of the enzyme. The iPLA2s are ubiquitously expressed, sha...
Calcium-independent phospholipase A2γ (iPLA2γ) and its roles in cellular functions and diseases [0.03%]
钙非依赖型磷脂酶A2γ（iPLA2γ）及其在细胞功能和疾病中的作用
Shuntaro Hara,Emiko Yoda,Yuka Sasaki et al.
Shuntaro Hara et al.
Calcium-independent phospholipase A2γ (iPLA2γ)/patatin-like phospholipase domain-containing lipase 8 (PNPLA8) is one of the iPLA2 enzymes, which do not require Ca2+ ion for their activity. iPLA2γ is a membrane-bound enzyme with unique fe...
Of mice and men: The physiological role of adipose triglyceride lipase (ATGL) [0.03%]
脂联素胰脂酶（ATGL）的生理作用：小鼠与人类中的比较研究
Renate Schreiber,Hao Xie,Martina Schweiger
Renate Schreiber
Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view on intracellular triglyceride (TG) mobilization - a process termed lipolysis. ATGL initiates the hydrolysis of TGs to release fatty acids (FAs) that ar...
Molecular characterization of Penicillium oxalicum 6R,8R-linoleate diol synthase with new regiospecificity [0.03%]
具有新立体选择性的青霉菌氧化学酸二醇合成酶的分子特征研究
Min-Ju Seo,Woo-Ri Kang,Eun-Joo Yang et al.
Min-Ju Seo et al.
Diol synthase-derived metabolites are involved in the sexual and asexual life cycles of fungi. A putative diol synthase from Penicillium oxalicum was found to convert palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6)...
DGAT1 deficiency disrupts lysosome function in enterocytes during dietary fat absorption [0.03%]
DGAT1缺乏通过破坏肠道细胞中膳食脂肪吸收过程中的溶酶体功能来扰乱肠道健康
Yu-Han Hung,Kimberly K Buhman
Yu-Han Hung
Enterocytes, the absorptive cells of the small intestine, mediate the process of dietary fat absorption by secreting triacylglycerol (TAG) into circulation. When levels of dietary fat are high, TAG is stored in cytoplasmic lipid droplets (C...