ATGL-mediated lipolysis is essential for myocellular mitochondrial function, mitochondria-lipid droplet interaction and mitochondrial network connectivity [0.03%]
ATGL介导的脂解对维持肌细胞线粒体功能、线粒体-脂滴相互作用及线粒体网络连接是必需的
Anne Gemmink,Tineke van de Weijer,Gert Schaart et al.
Anne Gemmink et al.
Defects in Adipose tissue TriGlyceride Lipase (ATGL)-mediated myocellular lipid droplet (LD) lipolysis results in mitochondrial dysfunction of unknown origin, which can be rescued by PPAR agonists. Here we examine if ATGL-mediated lipolysis...
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels [0.03%]
鞘氨醇诱导的溶酶体膜透化：与亚细胞氧化水平的相互作用
Guodong Cheng,Changxi Qi,Huiling Xu et al.
Guodong Cheng et al.
Sphinganine (SA), a fundamental sphingolipid whose cytotoxicity remains incompletely characterized, has received less attention compared to other sphingoid bases. Here, we demonstrate that SA predominantly triggers cell death via lysosomal ...
Melatonin ameliorates ox-LDL-induced lipid accumulation and enhances ABCA1 expression in VSMCs via inhibition of the TRPV1-Ca2+-calpain signaling pathway [0.03%]
褪黑素通过抑制TRPV1-Ca2+-钙蛋白酶信号途径缓解氧化低密度脂蛋白诱导的血管平滑肌细胞内脂质蓄积并增强其ABCA1表达
Yuehong Tang,Yujiao Peng,Yaling Zhang et al.
Yuehong Tang et al.
Oxidized low-density lipoprotein (ox-LDL) has been shown to induce significant lipid accumulation and disrupt cholesterol homeostasis in vascular smooth muscle cells (VSMCs), which may contribute to the development of atherosclerosis (AS). ...
Functional analysis and regulation mechanism of FGF19 on lipid metabolism in liver of large yellow croaker (Larimichthys crocea) [0.03%]
FGF19对大黄鱼肝脏脂代谢的功能及调控机制分析
Jianlong Du,Yuning Sun,Jinze Zhang et al.
Jianlong Du et al.
Fibroblast growth factor 19 (FGF19) is a key intestinally secreted factor in mammals, its physiological role in teleost remains largely unclear. This study aimed to investigate the function and underlying mechanisms of FGF19 in the regulati...
Regulation of macroautophagy and microautophagic lipophagy by phosphatidylserine synthase Cho1 and external ethanolamine [0.03%]
卵磷脂合成酶Cho1和外源乙醇胺调控巨自噬和微自噬脂自噬作用
Nanaru Mineoka,Rikako Konishi,Yuri Nakashima et al.
Nanaru Mineoka et al.
Phospholipids play crucial roles in autophagy; however, the underlying mechanisms remain elusive. We previously found that the phosphatidylserine (PtdSer) transporter Osh5 is critical for autophagosome formation. Therefore, in this study, w...
Induction of lipid autophagy by chitosan-coated selenium nanoparticles mitigates NAFLD in vitro and in vivo [0.03%]
壳聚糖硒纳米颗粒诱导脂质自噬可改善体外和体内的非酒精性脂肪肝病
Yanqiu Zhu,Yihan Wang,Chenglong Xia et al.
Yanqiu Zhu et al.
Excessive lipid accumulation within the liver is a main factor inducing non-alcoholic fatty liver diseases (NAFLD). Chitosan coated selenium nanoparticles (CS-SeNPs), a new kind of selenium supplement. In vitro study, CS-SeNPs remarkably de...
The multifaceted phosphatidylinositol 5 phosphate 4-kinase proteins: molecular properties and biological functions [0.03%]
多面体磷脂酰肌醇5磷酸4激酶蛋白：分子特性及生物学功能
Harini Krishnan,Aishwarya Venugopal,Preethi Alex et al.
Harini Krishnan et al.
Phosphoinositides are regulators of key cell biological processes such as plasma membrane function, vesicular transport, cytoskeletal and nuclear organization. In turn, their levels are tightly controlled by the function of lipid kinases an...
Arabidopsis AtCYP71B23: Detection of non-CYP74 enzyme of oxylipin biosynthesis [0.03%]
拟南芥AtCYP71B23：识别氧脂素生物合成中的非CYP74酶
Svetlana S Gorina,Natalia V Lantsova,Tatiana M Iljina et al.
Svetlana S Gorina et al.
The CYP71 clan comprises the majority of Arabidopsis thaliana P450s. The functional role of the great majority of CYP71 clan enzymes remains unknown hitherto. Some Arabidopsis CYP71B subfamily proteins, such as AtCYP71B23, exhibit primary s...
Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation [0.03%]
带有p.E297G突变的胆盐出口泵功能缺陷型小鼠模型的构建与表征
Antonia Felzen,Willemien F J Hof,Hilde de Vries et al.
Antonia Felzen et al.
Background & aims: Bile Salt Export Pump (BSEP) deficiency is a rare genetic cholestatic liver disease, often necessitating liver transplantation. The p.E297G missense mutation is associated with residual BSEP function in...
Decoding class II PI3K signaling: From membrane identity to human disease [0.03%]
剖析PI3K类第二信号转导：从膜定位到人类疾病
Roberta Rubino,Gabriele Squillero,Lorenzo Prever et al.
Roberta Rubino et al.
This review provides an integrated overview of the current understanding of class II PI3Ks, with particular attention to their structural and enzymatic properties, lipid substrate specificity, and emerging roles in membrane trafficking, cel...