Adcy8 deficiency contributes to impaired lipolysis and an increased prevalence of obesity in mice [0.03%]
Adcy8缺陷通过损害脂解作用促进小鼠肥胖发生率升高
Mengxue Han,Qing Shu,Ruili Yu et al.
Mengxue Han et al.
Obesity is a global chronic disease characterized by an imbalance in energy homeostasis. Dysfunction of adipocytes and adipose tissue are fundamental defects that contribute to the development of obesity. Adenylate cyclase 8 (ADCY8) serves ...
Hyperoxic recovery impacts on metabolic adaptations induced by hypoxic exercise: A lipidomics approach [0.03%]
富氧恢复对缺氧运动诱导的代谢适应性的影响：脂质组学方法研究
Simone Serrao,Eleonora Bossi,Vanna Denti et al.
Simone Serrao et al.
This study investigates the effect of recovery phases in either hyperoxic air or hypoxic air during physical exercise in hypoxia on lipid metabolism in 11 male athletes. We observed a long-term effect leading to increased plasma triacylglyc...
Eicosapentaenoic acid inhibits cholesterol efflux pathways from cholesterol-loaded human THP-1 macrophages by reducing the hydrolysis of cholesteryl esters mediated by carboxylesterase 1 [0.03%]
二十碳五烯酸通过减少脂肪酶1介导的胆固醇酯水解抑制胆固醇负载的人单核细胞胆固醇流出路径
Maxime Nowak,Hani Dakroub,Benoît Noel et al.
Maxime Nowak et al.
A diet high in n-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) (C20:5 n-3), is cardioprotective. PUFAs integrate into membrane phospholipids, altering membrane protein function. We investigated the effects ...
Upregulation of the maresin pathway and PGE2 metabolism in the failing human left ventricle [0.03%]
人左心室功能障碍时maresin通路及PGE2代谢的上调作用
Amel Bouhadoun,Hasanga D Manikpurage,Gaelle Merheb et al.
Amel Bouhadoun et al.
Chronic inflammation is involved in the pathogenesis of heart failure (HF), with cardiac remodeling and fibrosis resulting from sustained myofibroblasts activation. This is due to an imbalance between pro-inflammatory and pro-resolving medi...
A natural thiophene from Eclipta prostrata (L.) combats obesity by enhancing adipocytes thermogenesis in high-fat diet-fed obese mice [0.03%]
穿心莲内酯通过增强高脂饮食喂养的肥胖小鼠的脂肪细胞产热来对抗肥胖
Xiaochun Zhang,Chunhua Lu,Yuemao Shen
Xiaochun Zhang
The rising global prevalence of obesity has become a serious public health concern. Recent studies have revealed that natural products derived from medicinal plants can activate adipocytes thermogenesis, presenting promising therapeutic str...
The role of ancient ubiquitous protein 1 (Aup1) in regulating hepatic lipid droplet levels, endoplasmic reticulum stress, and inflammation in zebrafish (Danio rerio) [0.03%]
古 ubiquitin 蛋白 1(AUP1)在调节斑马鱼肝脂滴水平、内质网应激和炎症中的作用
Shuangyang Xu,Yanan Shen,Zengqi Zhao et al.
Shuangyang Xu et al.
Excessive supplementation of palm oil (PO) in aquafeeds induces hepatic endoplasmic reticulum (ER) stress and inflammatory responses in fish, while lipid droplet (LD) formation has been demonstrated to alleviate stress and inflammation by s...
Tumor necrosis factor alpha-induced activation of SREBP2 promotes cholesterol biosynthesis in cholestasis [0.03%]
肿瘤坏死因子α激活SREBP2促进胆汁淤积中的胆固醇生物合成
Ziqian Xu,Xinyu Cao,Zhixian Zhu et al.
Ziqian Xu et al.
Background and aims: Cholestasis is frequently associated with lipid metabolism disorders, elevated cholesterol levels and disruptions in bile acid homeostasis. Nevertheless, the mechanisms underlying cholesterol elevatio...
Phosphoinositide acyl chain diversity: comparative analysis across species and mouse tissues [0.03%]
磷脂肌醇酰基链的多样性：跨物种和小鼠组织的比较分析
David Barned,Vishnu Janardan,John Swales et al.
David Barned et al.
Cells create acyl chain compositions for their phosphoinositide (PIPn) pools that are distinct from other phospholipid classes. While some lower eukaryotes present highly heterogeneous PIPn (e.g., yeast, fly), more complex organisms typical...
Neurogenin 2-induced central neurons from iPSC-established patients with NPC display attenuated neurite outgrowth while accumulating cholesterol [0.03%]
由NPC患者诱导的多能干细胞建立的神经元中心神经胶质细胞分化显示胆固醇累积并抑制轴突生长
Miki Igarashi,Takashi Miyajima,Chen Wu et al.
Miki Igarashi et al.
Niemann-Pick disease type C (NPC) is a lysosome disease hallmarked by autosomal recessive mutations in the NPC1 or NPC2 genes. It results in the accumulation of unesterified cholesterol in the late endosome/lysosome compartment, and then in...
Laminar shear stress promotes accumulation of polyunsaturated fatty acid in aortic endothelial cells through upregulation of LPCAT3 enzyme activity [0.03%]
层流剪切应力通过上调LPCAT3酶活性促进内皮细胞多不饱和脂肪酸的积累
Delphine Bousquet,Nicolas Guillot
Delphine Bousquet
Objective: Endothelial cells (ECs) play an important role in tissue homeostasis. Hemodynamic laminar shear stress are involved in both the physiological and pathological function of endothelial cells EC. Lipid metabolism ...