MiR-432 mediates bidirectional regulation in the determination of adipocyte fate [0.03%]
MiR-432在脂肪细胞命运决定中的双向调控作用中介效应
Liming Tian,Guan Wang,Shuhong Zhang et al.
Liming Tian et al.
Fat deposition represents a fundamental physiological process in mammalian energy metabolism, yet its molecular regulatory mechanisms remain incompletely understood. Adipocytes, the primary site of fat storage, develop through proliferation...
A retrospective on phosphatidylinositol transfer proteins (PITPs) - A fifty-year journey [0.03%]
磷脂酰肌醇转移蛋白(PITPs)的回顾性分析——五十年的研究历程
Shamshad Cockcroft
Shamshad Cockcroft
This retrospective traces the evolution of our understanding of the phosphatidylinositol transfer protein (PITP) family over the past fifty years, beginning with its purification. I summarise the early identification of PITPs as phosphatidy...
ACADVL upregulation is associated with placental ferroptosis in intrahepatic cholestasis of pregnancy [0.03%]
母体妊娠期肝内胆汁淤积症胎盘铁死亡与ACADVL上调表达相关性研究
Mi Tang,Jianghui Cai,Ling Zhang et al.
Mi Tang et al.
Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by maternal pruritus and elevated total bile acid concentrations during pregnancy, posing severe fetal risks associated with placental ...
1H NMR studies of alterations in lipoprotein profiles in women diagnosed with gestational diabetes mellitus (GDM) and after delivery [0.03%]
妊娠糖尿病妇女脂蛋白剖面变化的核磁共振氢谱研究及产后对比分析
Izabela Burzynska-Pedziwiatr,Malgorzata Bukowiecka-Matusiak,Barbara Pacholczyk-Sienicka et al.
Izabela Burzynska-Pedziwiatr et al.
The lipid abnormalities are observed in pregnant women with normal glucose tolerance (NGT) and those diagnosed with gestational diabetes mellitus (GDM), but in the latter, they are intensified and may indicate underlying metabolic dysfuncti...
Curcumol ameliorates high-fat diet-induced hepatic fibrosis via dual regulation of FXR-CREB and Rab18-mediated hepatic stellate cell lipophagy [0.03%]
姜黄素通过FXR-CREB和Rab18介导的HSC脂自噬双重调节改善高脂饮食诱导的肝纤维化
Na Wei,Wanyu Feng,Meijun Pan et al.
Na Wei et al.
Curcumol, a bioactive constituent derived from Rhizoma Curcumae roots, possesses anti-inflammatory and anti-viral properties. This study investigated its therapeutic effects on lipophagy in hepatic stellate cells (HSCs) and lipid accumulati...
MiR-424-3p suppresses adipogenesis via HNRNPA0 targeting and p53-mediated ferroptosis [0.03%]
miR-424-3p通过靶向HNRNPA0和介导p53依赖性铁死亡抑制脂肪生成
Meng Li,Yuqi Ye,Shasha Lin et al.
Meng Li et al.
MicroRNAs (miRNAs), a class of non-coding small RNAs, play critical roles in regulating adipocyte biology, including differentiation, proliferation, and lipid metabolism. This study investigates the role of miR-424-3p in adipogenesis. MiR-4...
Editorial: Celebrating 50 Years of Insight-Bob Michell's Legacy in Phosphoinositide Signalling [0.03%]
庆祝《信号转导》创刊50周年：Bob Mitchel爵士在磷脂酰肌醇信号传导领域的影响与传承
Shamshad Cockcroft,Phillip Hawkins,Len Stephens et al.
Shamshad Cockcroft et al.
Roles in physiology and disease of the inositol phosphatase synaptojanin 1 [0.03%]
肌醇磷酸酶synaptojanin 1的生理及病理作用
Pietro De Camilli
Pietro De Camilli
Synaptojanin 1 (Synj1) is a protein highly enriched in the nervous system which comprises tandemly arranged inositol 4-phosphatase and 5-phosphatase domains. Since its discovery as a synaptically enriched binding partner of SH3 domain conta...
Phosphoinositides at 50: From minor lipids to master organizers of polarity [0.03%]
磷脂酰肌醇五十年——从次要脂质到极性调控的主要组织者
Ama Gassama-Diagne
Ama Gassama-Diagne
Phosphoinositides (PIs) have been at the center of cell signaling and membrane biology since Michell's proposal of the PI-cycle in 1975. Over the past fifty years, these quantitatively minor lipids have emerged as versatile molecular organi...
Morgan M C Ricci,Claire C Weckerly,Gerald R V Hammond
Morgan M C Ricci
Phosphoinositides (PPIn) are low-abundance phospholipids that define membrane identity and direct compartment-specific signaling across eukaryotic cells. Marking fifty years since Michell's seminal 1975 review, we re-evaluate how the subcel...