Control of ALOX5 expression in monocytic cells using a synthetic riboswitch [0.03%]
利用合成核糖开关控制单核细胞中ALOX5的表达
Robin W Bruckhoff,Julia H Oberlis,Dieter Steinhilber et al.
Robin W Bruckhoff et al.
The human 5-lipoxygenase (5-LOX), which is encoded by the arachidonate 5-lipoxygenase (ALOX5) gene, has its canonical function in leukotriene (LT) biosynthesis, which controls inflammatory and allergic responses. Besides oxylipin formation ...
Polyunsaturated fatty acids in kidney diseases: Navigating the fine line between healing and damage [0.03%]
多不饱和脂肪酸与肾脏疾病：治疗与损伤之间的微妙平衡
Mehrdad Aghasizadeh,Ahmad Reza Bahrami,Maryam M Matin
Mehrdad Aghasizadeh
Polyunsaturated fatty acids (PUFAs) regulate renal inflammation through metabolites generated by COX, LOX, and CYP pathways. While prostaglandins, leukotrienes, and 20-hydroxyeicosatetraenoic acid (20-HETE) exacerbate kidney injury, epoxyei...
Effect of α-ketoglutarate on maternal lipid homeostasis and mitochondrial status perturbed by gestational arsenic exposure [0.03%]
α-酮戊二酸改善母体砷暴露造成的脂代谢紊乱及线粒体损伤效应研究
Tong Zhan,Shuang-Rui Bao,Ying Sun et al.
Tong Zhan et al.
Arsenic is a common environmental toxicant with known hepatotoxic effects, yet its impact on maternal lipid metabolism during pregnancy remains poorly understood. In this study, we established a pregnant mouse model to investigate the effec...
Linarin alleviates high-fat diet-induced NAFLD via modulating the PI3K/Akt/mTOR pathway, autophagy, and gut microbiota [0.03%]
通过调节PI3K/Akt/mTOR途径、自噬和肠道微生物群，Linarin缓解高脂饮食引起的NAFLD
Mengfan Lv,Yaxin Zhai,Hao Yu et al.
Mengfan Lv et al.
Linarin (Lin) is a flavonoid compound widely found in traditional herbal medicines and is recognized for its diverse biological properties, including anti-inflammatory, analgesic, antioxidant, hepatoprotective, and anti-apoptotic effects. N...
Metformin promotes lipid droplet-mitochondria coupling and improves insulin secretion in pancreatic β-cells exposed to lipotoxicity [0.03%]
二甲双胍促进脂滴-线粒体偶联改善脂毒性损伤胰岛β细胞的胰岛素分泌
Aneta M Dobosz,Ewelina Krogulec,Nataniel Stefanowski et al.
Aneta M Dobosz et al.
Lipotoxicity that is caused by excess lipid accumulation is a major factor that contributes to gradual impairments of β-cell function and the development of type 2 diabetes. Metformin has shown protective effects against lipid-induced dama...
Molecular mechanisms of cytochrome P450-derived epoxy-fatty acids neuroprotection [0.03%]
细胞色素P450衍生的环氧脂肪酸神经保护作用的分子机制
Cynthia Navarro-Mabarak,Julio Morán
Cynthia Navarro-Mabarak
The epoxyeicosatrienoic acids (EETs) are metabolites that result from the oxidation of the arachidonic acid by cytochrome P450 (CYP) epoxygenases. EETs are known to exert anti-inflammatory, antioxidant, vasodilatory, pro-angiogenic and anti...
Fatty acid binding protein 1 (FABP1) depletion promotes an oxidative metabolic shift in Caco-2 colorectal cancer cells [0.03%]
脂肪酸结合蛋白1（FABP1）的耗竭可促进Caco-2结直肠癌细胞向氧化代谢转变
Delfina Lucía Borús,Giorgia Zadra,Daniel Minsky et al.
Delfina Lucía Borús et al.
Lipid metabolism reprogramming is a well-established hallmark of many cancer types, including colorectal cancer (CRC). Nevertheless, a clear understanding on how fatty acid (FA) metabolism is fine-tuned during CRC development and progressio...
Paulo Gaspar,André R A Marques,Maria J Ferraz et al.
Paulo Gaspar et al.
Glucocerebrosidase (GCase) catalyzes the lysosomal degradation of glucosylceramide (GlcCer). GCase deficiency results in Gaucher disease (GD), a lysosomal storage disorder with characteristic hepatosplenomegaly. Transport of GCase to lysoso...
Partial inhibition of adipose CIDEC improves insulin sensitivity and increases energy expenditure in high-fat diet-fed mice via activating ATGL-PPARα pathway [0.03%]
脂肪组织CIDEC部分抑制通过激活ATGL-PPARα通路改善高脂饮食喂养小鼠的胰岛素敏感性和增加能量消耗
Qinghua Fu,Peng Wang,Weilin Li et al.
Qinghua Fu et al.
Obesity poses a significant risk for metabolic disorders, such as insulin resistance and metabolic-associated fatty liver disease (MAFLD), yet effective treatments remain limited. Cell Death-Inducing DNA Fragmentation Factor-α-Like Effecto...
The inositol 5-phosphatases OCRL and INPP5B: Cellular functions and roles in disease [0.03%]
肌醇磷酸酶OCRL和INPP5B的细胞功能及其在疾病中的作用
Aloka de Sa,Gaoyu Li,Connor Byrne et al.
Aloka de Sa et al.
OCRL and INPP5B are evolutionary conserved inositol 5-phosphatases that are preferentially hydrolyse PI(4,5)P2, a key regulator of numerous cellular processes. Mutation of OCRL causes Lowe syndrome and Dent-2 disease that manifest in the ey...