Hypertriglyceridemia impairs HDL functionality, promotes macrophage metabolic activation and exacerbates antigen-induced rheumatoid arthritis in mice which can be reversed by fenofibrate treatment [0.03%]
高甘油三酯血症损害HDL功能，促进巨噬细胞代谢活化并加剧抗原诱导的小鼠类风湿性关节炎且苯扎贝特处理可逆转上述作用
Isidoros Axiotis,Asimina Kakale,Despina Lazaridou et al.
Isidoros Axiotis et al.
Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk, partly attributed to altered lipid metabolism. Apolipoprotein C-III (ApoC-III), a key regulator of triglyceride-rich lipoproteins in the plasma, has b...
Pulmonary surfactant protein SP-C regulates lipid vesicle uptake by alveolar type II cells and macrophages: Role of lipids, palmitoylation, and environment [0.03%]
肺表面活性物质蛋白SP-C通过脂质、棕榈酰化和环境调节肺泡II型细胞及巨噬细胞的脂质囊泡内吞作用及其机制研究
Mishelle Morán-Lalangui,Marta Villoslada-González,Carmen Hevia-Lorenzo et al.
Mishelle Morán-Lalangui et al.
Pulmonary surfactant protein C (SP-C) may play a key role in alveolar homeostasis by modulating vesicle uptake in alveolar cells. This study explores how SP-C regulates internalization of model unilamellar lipid vesicles by type II alveolar...
Age-related changes in cardiolipin profile and functional consequences of altered fatty acid supply [0.03%]
与年龄相关的线粒体四烯酸卡尼汀水平下降及脂肪酸组成变化导致的心肌收缩功能受损
Philipp W Weiß,Philip P Kaltenborn,Christiane Frahm et al.
Philipp W Weiß et al.
Cardiolipins (CLs) are primarily expressed in the inner mitochondrial membrane where they play essential roles in membrane architecture and mitochondrial functions. CLs have a unique structure characterized by four acyl chains with differen...
Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease [0.03%]
调控I类磷脂酰肌醇3-激酶（PI3K）的分子机制及其在人类疾病中的靶向作用
Alexandria L Shaw,Isobel Barlow-Busch,John E Burke
Alexandria L Shaw
The class I phosphoinositide 3-kinase pathway (PI3K) is a master regulator of cellular growth, and plays essential roles in controlling immune cell function, metabolism, chemotaxis and proliferation. Activation of class I PI3Ks generates th...
Combination of hydroxycitric acid and capsaicin regulates IRS-1/AMPK-mTOR-SREBP-1c Axis/NLRP3-NF-κB/Nrf-2-ARE signaling pathways to ameliorate the two-hit process in high-fat diet-induced hepatic steatosis [0.03%]
羟基柠檬酸和辣椒素通过调节IRS-1/AMPK-mTOR-SREBP-1c轴/NLRP3-NF-κB/Nrf-2-ARE信号通路缓解高脂饮食诱导的二次打击肝脂肪变性过程
V V Sathibabu Uddandrao,Deepthi Krishna,M N Vasantha et al.
V V Sathibabu Uddandrao et al.
Metabolic (Dysfunction) Associated Steatotic Liver Disease (MASLD) is a complex metabolic condition, the progression of which toward steatohepatitis can be explained by the 'two-hit' hypothesis: the first hit involves lipid accumulation, an...
Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis [0.03%]
花生四烯酸诱导的内皮细胞凋亡中p38MAPK和Caspase-1对脂滴生物发生的作用
Youjia Du,Xucheng Lv,Yan Shen et al.
Youjia Du et al.
Endothelial cells form a single layer of endothelium that lines the inner surface of the blood vessels. Healthy endothelial cells play important roles in the maintenance of the circulation homeostasis, while endothelial cell apoptosis has b...
Sterol analysis of MARCHF6-deficient cells reveals a new pinch point in the cholesterol biosynthesis pathway [0.03%]
sterol分析揭示了MARCHF6缺陷细胞中胆固醇生物合成途径中的一个新的瓶颈点
Nicole M Fenton,Laura J Sharpe,Andrew M Jenner et al.
Nicole M Fenton et al.
Echinacoside suppresses macrophage lipid accumulation and attenuates atherosclerosis via the MDM2/PPARγ/ABCA1 signaling axis [0.03%]
雷公藤内酯通过MDM2/PPARγ/ABCA1信号轴抑制巨噬细胞脂质积累和动脉粥样硬化形成
Qin-Yi Zhou,Jing Zhou,Zhao-Bing Li et al.
Qin-Yi Zhou et al.
Macrophage cholesterol efflux, a critical step in reverse cholesterol transport, plays a pivotal role in the attenuation of atherosclerosis. Echinacoside, a natural compound with anti-inflammatory, antioxidant, and antitumor properties, has...
Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation [0.03%]
多供者间充质干细胞成骨分化的脂代谢适应性研究
Daniela S C Bispo,Inês Graça,Catarina S H Jesus et al.
Daniela S C Bispo et al.
Mesenchymal stem cell (MSC) osteodifferentiation is accompanied by important lipid metabolic adaptations, which may reveal relevant biomarkers and potential osteoinductive species. However, high donor variability remains a challenge for bio...
Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes [0.03%]
与增殖和上皮间质转化表型相关的乳腺癌细胞系具有不同的脂质组学谱型
Hanneke Leegwater,Zhengzheng Zhang,Xiaobing Zhang et al.
Hanneke Leegwater et al.
Rewiring of lipid metabolism is a hallmark of cancer, supporting tumor growth, survival, and therapy resistance. However, lipid metabolic heterogeneity in breast cancer remains poorly understood. In this study, we systematically profiled th...