Spatial gradients of lipase activity govern lipid droplet remodeling in the zebrafish embryo [0.03%]
斑马鱼胚胎中脂酶活性的梯度决定脂滴重构
Sudipta Sarkar,Sayani Haldar,Subhasis Mandal et al.
Sudipta Sarkar et al.
Early zebrafish embryos rely on maternally supplied yolk lipids to fuel growth before the onset of feeding; yet, how these lipids are mobilized and redistributed remains poorly understood. Here, we combine live imaging with the solvatochrom...
Study on the response of Punicalagin to AGEs - Induced inflammation based on lipidomics [0.03%]
基于脂质组学的 punicalagin 对AGEs诱导炎症反应的研究
Lang Lang,Jiaqi He,Xinwen Zhang et al.
Lang Lang et al.
Background: Punicalagin (PUN), the main bioactive in pomegranate peel polyphenols, plays a key therapeutic effect against diverse ailments, especially inflammatory diseases. Advanced Glycation End Products (AGEs) can disr...
Metabolic interaction between catecholamines and cholesterol derivatives is a potential mechanism for immune homeostasis of chicken adipose tissue [0.03%]
儿茶酚胺与胆固醇衍生物之间的代谢相互作用是调控鸡脂肪组织免疫稳态的潜在机制
Jia Li,Yi Jiang,Meiqi Xia et al.
Jia Li et al.
In recent years, the immunomodulatory role of adipose tissue (AT) has gained attention, yet the metabolic basis for immune homeostasis in AT remains unclear. Catecholamines (CAs) activate adipocyte β3-adrenergic receptors (β3-AR) to promo...
METTL3 mitigates angiotensin II-induced renal hypertensive injury by regulating fatty acid oxidation [0.03%]
METTL3通过调节脂肪酸氧化来缓解血管紧张素II诱导的肾高血压损伤
Xue-Jie Fei,Meng-Yao Xie,Ruo-Ran Liu et al.
Xue-Jie Fei et al.
Hypertension is a major contributor to cardiovascular diseases and all-cause mortality worldwide. It can cause damage to multiple target organs, with the kidneys being particularly susceptible. Conditional knockdown of methyltransferase-lik...
Tomoyuki Suzuki,Keisuke Yanagida,Takao Shimizu et al.
Tomoyuki Suzuki et al.
Platelet-activating factor (PAF) is a key mediator of systemic anaphylaxis. The principal target cell type of PAF in systemic anaphylaxis remains unclear. Endothelial cell-specific PAFR-deficient mice were protected from mortality in PAF-in...
Enzymatic basis underlying the biosynthesis of Δ7-desaturated C22 polymethylene-interrupted fatty acids across marine invertebrates [0.03%]
海洋无脊椎动物Δ7去饱和C22间断多亚甲基脂肪酸生物合成的酶学基础研究
Yingying Peng,Ai Iinuma,Yo Nakano et al.
Yingying Peng et al.
Polymethylene-interrupted fatty acids (PMI-FA) represent a structurally unusual class of polyunsaturated fatty acids characterised by double bonds separated by two or more methylene groups. Among them, Δ7-desaturated C22 PMI-FA are widely ...
trans-Cinnamic acid alleviates high-fat diet induced hepatic steatosis by activating AMPK-mTOR pathway [0.03%]
对映-香豆酸通过激活AMPK-mTOR途径缓解高脂饮食诱导的肝脂肪变性
Kun Jia,Lei Zhang,Peng Shi et al.
Kun Jia et al.
trans-Cinnamic acid (CA), a bioactive compound from cinnamon bark, exhibits well-known pharmacological properties; however, its effects and underlying mechanisms in hepatic steatosis (HS) remain elusive. Therefore, this study aims to evalua...
Crucial importance of the chirality of phosphatidylglycerol for growth and photosynthesis in Synechocystis sp. PCC 6803 [0.03%]
磷脂甘油酸的手性对于蓝藻丝氨酸PCC 6803生长和光合作用的至关重要性
Yoshiki Tanase,Masato Abe,Keisuke Yamada et al.
Yoshiki Tanase et al.
The chirality of biomolecules such as sugars and amino acids is highly specific and critical for biological functions. Phosphatidylglycerol (PG), the sole major phospholipid in cyanobacterial membranes, plays an indispensable role in photos...
LncRNA SNHG5 promotes macrophage lipid accumulation and aggravates atherosclerosis by targeting the miR-216a-5p/HDAC3/ABCA1 axis [0.03%]
长链非编码RNA SNHG5通过靶向miR-216a-5p/HDAC3/ABCA1轴促进巨噬细胞脂质积累并加重动脉粥样硬化
Xian Liu,Hui-Hui Wang,Xin-Yu Lan et al.
Xian Liu et al.
Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) has been implicated in cell death, glucose homeostasis, and tumor progression, yet its role in atherosclerosis (AS) remains unclear. In this study, SNHG5 expression was markedly ele...
Jiehan Li,Yuchang Li,Vassilios Papadopoulos
Jiehan Li
Obesity is frequently associated with elevated serum cholesterol and 27-hydroxycholesterol (27HC), a metabolite recently identified as a key link between hypercholesterolemia and increased cancer risk. 27HC exerts pathophysiological effects...