The multifaceted phosphatidylinositol 5 phosphate 4-kinase proteins: molecular properties and biological functions [0.03%]
多面体磷脂酰肌醇5磷酸4激酶蛋白：分子特性及生物学功能
Harini Krishnan,Aishwarya Venugopal,Preethi Alex et al.
Harini Krishnan et al.
Phosphoinositides are regulators of key cell biological processes such as plasma membrane function, vesicular transport, cytoskeletal and nuclear organization. In turn, their levels are tightly controlled by the function of lipid kinases an...
Arabidopsis AtCYP71B23: Detection of non-CYP74 enzyme of oxylipin biosynthesis [0.03%]
拟南芥AtCYP71B23：识别氧脂素生物合成中的非CYP74酶
Svetlana S Gorina,Natalia V Lantsova,Tatiana M Iljina et al.
Svetlana S Gorina et al.
The CYP71 clan comprises the majority of Arabidopsis thaliana P450s. The functional role of the great majority of CYP71 clan enzymes remains unknown hitherto. Some Arabidopsis CYP71B subfamily proteins, such as AtCYP71B23, exhibit primary s...
Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation [0.03%]
带有p.E297G突变的胆盐出口泵功能缺陷型小鼠模型的构建与表征
Antonia Felzen,Willemien F J Hof,Hilde de Vries et al.
Antonia Felzen et al.
Background & aims: Bile Salt Export Pump (BSEP) deficiency is a rare genetic cholestatic liver disease, often necessitating liver transplantation. The p.E297G missense mutation is associated with residual BSEP function in...
Decoding class II PI3K signaling: From membrane identity to human disease [0.03%]
剖析PI3K类第二信号转导：从膜定位到人类疾病
Roberta Rubino,Gabriele Squillero,Lorenzo Prever et al.
Roberta Rubino et al.
This review provides an integrated overview of the current understanding of class II PI3Ks, with particular attention to their structural and enzymatic properties, lipid substrate specificity, and emerging roles in membrane trafficking, cel...
Palmitoyl-protein thioesterase 1 mediated depalmitoylation regulates lipid accumulation in the oleaginous fungus Mucor circinelloides [0.03%]
棕榈酰蛋白硫酯酶 1 介导的去棕榈酰化调控产油真菌穆氏腐皮壳中脂质积累
Hequn Li,Zhen Wang,Hongjuan Yuan et al.
Hequn Li et al.
Palmitoyl-protein thioesterase 1 (PPT1), a key depalmitoylating enzyme, modulates substrate protein function and lipid metabolism through enzymatic thioester bond hydrolysis of the palmitoyl-thioester bond. While PPT1 may regulate lipid met...
ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress [0.03%]
ABHD6抑制可减轻小鼠内毒素应激下的促炎反应并促进巨噬细胞向抗炎表型极化
P Poursharifi,C Schmitt,I Chenier et al.
P Poursharifi et al.
α/β-hydrolase domain-containing-6 (ABHD6) hydrolyzes various lipids, including monoacylglycerols (MAGs). Pharmacological inhibition of ABHD6 with WWL70 is anti-inflammatory in animal models. However, because of the multiple substrates of ...
Physiological role of plasmalogen homeostasis in the liver - A link to cholesterol metabolism [0.03%]
肝脏磷脂类稳态的生理作用——与胆固醇代谢的关系
Masanori Honsho,Fabian Dorninger,Johannes Berger et al.
Masanori Honsho et al.
In mammals, plasmalogens are enriched in the brain, kidney, and heart, while the lowest amounts of plasmalogens are found in the liver. The physiological significance of the low level of plasmalogens in the liver remains unknown. Here, we u...
Integrated proteomic and metabolomic analysis reveals lipid metabolic dysregulation and ferroptosis as potential drivers of placental dysfunction in intrahepatic cholestasis of pregnancy [0.03%]
整合蛋白质组学和代谢组学分析揭示了妊娠期肝内胆汁淤积胎盘功能障碍的潜在驱动因素为脂质代谢调节异常和铁死亡
Ruirui Dong,Gaoying Wang,Yingxian Shi et al.
Ruirui Dong et al.
Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse fetal outcomes, while current biomarkers such as total bile acid remain suboptimal. This study aimed to identify novel biomarkers and clarify metabolic pathways underlyi...
John Z Chan,Michelle V Tomczewski,Antonia N Berdeklis et al.
John Z Chan et al.
Barth Syndrome (BTHS) is an ultra-rare, X-linked mitochondrial disorder caused by a variety of different mutations in the cardiolipin remodeling gene TAFAZZIN that results in cardiac and skeletal myopathy, as well as immunological deficits....
ApoB: The intracellular protein detection dilemma in lipoprotein biology [0.03%]
APOB：细胞内蛋白质检测的困境及脂蛋白生物学中的作用
Ankia Visser,Floris A Feiner,Willemien Heerema-van Zwol et al.
Ankia Visser et al.