HSF4 promotes lipid peroxidation by transcriptionally regulating ALOX15 during lens terminal differentiation [0.03%]
HSF4通过转录调节ALOX15促进晶状体终末分化过程中的脂质过氧化作用
Shaoli Zhang,Yinan Wang,Ning Jiang et al.
Shaoli Zhang et al.
Lens fibers undergo organelle degradation during lens terminal differentiation. Defects in organelle degradation of lens fibers lead to congenital cataract. As a member of heat shock factor family, HSF4 governs lens development by regulatin...
Corrigendum to "Inducible beige adipocytes improve impaired glucose metabolism in interscapular BAT-removal mice" [Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1866 (2021) 158871] [0.03%]
“诱导性贝吉细胞改善肩胛间褐色脂肪组织切除小鼠受损的葡萄糖代谢”一文的勘误[BBA-脂类 metabolism 1866 (2021) 158871]
Xiao-Wei Jia,Dong-Liang Fang,Xin-Yi Shi et al.
Xiao-Wei Jia et al.
Caveolin-2 knockout suppresses the formation and progression of oral leukoplakia via lipid metabolism disruption [0.03%]
Caveolin-2基因敲除通过干扰脂质代谢抑制口腔白斑的形成及进展
Xiao-Jie Chen,Yu-Ting Bai,Ming-Jing Jiang et al.
Xiao-Jie Chen et al.
Background: Caveolin-2 (CAV2) is a lipid droplet (LD)-associated protein. Its role in oral leukoplakia (OLK), an oral potentially malignant disorder, and the underlying lipid metabolism mechanisms remain unclear. ...
Lipid droplet isolation as a novel platform for spectroscopic investigation of cargo modifications [0.03%]
脂滴分离作为一种新颖的用于光谱学研究货物修饰的平台技术
Karolina Chrabąszcz,Agnieszka Panek,Katarzyna Pogoda
Karolina Chrabąszcz
Lipid droplets (LDs) are dynamic organelles that coordinate lipid storage, trafficking, and metabolic adaptation under physiological and stress conditions. Despite their emerging role in cellular homeostasis, the molecular basis of treatmen...
Maternal vitamin A deficiency programs offspring visceral hypersensitivity through RARβ-COX-2/PGE2 signaling [0.03%]
母体维生素A缺乏通过RARβ-COX-2/PGE2信号传导使后代内脏过敏化
Mengxia Tang,Lue Gou,Wenzhi Bao et al.
Mengxia Tang et al.
Visceral hypersensitivity (VH) is regarded as a core pathophysiological mechanism in irritable bowel syndrome (IBS). Although maternal vitamin A deficiency (VAD) during pregnancy has been linked to gastrointestinal dysfunction in offspring,...
Chisom J Onu,Michael Adu,Dania Jabbar et al.
Chisom J Onu et al.
Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from yea...
Trans-10, cis-12 conjugated linoleic acid modulates offspring hepatic lipid metabolism by activating AMPK pathway associated with altered gut microbiota [0.03%]
反式10,顺式12共轭亚油酸通过改变肠道菌群激活AMPK信号通路调节子代肝脂代谢
Shuai Yu,Hongbing Lu,Yu Rao et al.
Shuai Yu et al.
Objective: Trans-10, cis-12 conjugated linoleic acid (t10c12-CLA) can affect lipid metabolism, leading to weight loss and attracting widespread attention. However, its suitability for use in lactating mothers remains uncl...
Enhydrin from yacon attenuates atherosclerosis by modulating the FABP5/PPARγ/ABCA1 axis: An integrated multi-omics and in vivo validation [0.03%]
菊粉中的海德林通过调节FABP5/PPARγ/ABCA1轴抗动脉粥样硬化：多组学和体内验证集成研究
Chao Tian,Guiping He,Ling Zu et al.
Chao Tian et al.
Dysregulated lipid metabolism drives atherosclerosis (AS). Yacon, an Andean lipid-modulating tuber, exerts anti-AS potential, but mechanisms remain unclear. We integrated network pharmacology, machine learning, single-cell RNA sequencing (s...
Role of lipid droplet-mediated lipid peroxidation by GPX4 in docosahexaenoic acid-induced EA.hy926 endothelial cell ferroptosis [0.03%]
GPX4介导的脂滴依赖性脂质过氧化在DHA诱导的内皮细胞铁死亡中的作用研究
Youjia Du,Yan Shen,Ruotong Wang et al.
Youjia Du et al.
Endothelial cells (EC) form the inner lining of the blood vessels and are essential for the vascular homeostasis. EC death has been implicated in the pathology of vascular diseases. Our previous studies indicated that docosahexaenoic acid (...
Maximization of mitochondrial fatty acid oxidation by co-administration of PPARα agonist and peroxisomal β-oxidation inhibitor [0.03%]
PPARα激动剂与过氧化物酶体β氧化抑制剂的联用最大化线粒体脂肪酸氧化作用
Ziyu Zeng,Yicong Li,Junwei Cao et al.
Ziyu Zeng et al.
PPARα plays a pivotal role in regulating hepatic fatty acid oxidation and activation of PPARα has been well known to stimulate mitochondrial β-oxidation and has the potential to reduce hepatic lipid level, while evidences indicate that a...