Curcumin inhibits pancreatic steatosis in mice with high fat diet through YAP/P53 pathway and confirmed through ultrasonic imaging [0.03%]
黄酮通过YAP/P53途径抑制高脂饮食小鼠的胰脂肪变性并通过超声成像得到证实
Helin Ke,Ziwei Xu,Lina Han et al.
Helin Ke et al.
Aims: To investigate the mechanism by which curcumin inhibits pancreatic steatosis (PS), and the diagnostic value of ultrasonography in the pancreas of mice with obesity. ...
Production, characterization and biodistribution of therapeutic high-density lipoprotein-like nanoparticles reconstituted with or without histidine-tagged recombinant ApoA1 [0.03%]
组氨酸标签重组载脂蛋白A1重构的治疗性类高密度脂蛋白纳米颗粒的生产，特征和生物分布研究
Sarah Rosanaly,Marie Laurine Apalama,Matthieu Bringart et al.
Sarah Rosanaly et al.
High-density lipoproteins (HDLs) are known for their cardiovascular protection due to apolipoprotein A-1 (ApoA1), their primary protein. ApoA1 promotes cholesterol reverse transport and exhibits antioxidant and anti-inflammatory properties....
Preventive effect of siphonaxanthin, a carotenoid from green algae, against diabetic nephropathy and lipid metabolism insufficiency in skeletal muscle [0.03%]
绿藻类胡萝卜素岩藻黄质对糖尿病肾病和骨骼肌脂质代谢障碍的预防作用
Jiawen Zheng,Yuki Manabe,Tatsuya Sugawara
Jiawen Zheng
Diabetic nephropathy is a complication of diabetes mellitus characterized by the gradual progression of renal insufficiency, resulting in renal failure. Approximately 15 % or more of patients with type 2 diabetes mellitus have diabetic neph...
Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina [0.03%]
揭示BCO2在黄斑色素代谢中的功能：灵长类视网膜中的线粒体处理和表达
Chou Shen,Sepalika Bandara,Sanae S Imanishi et al.
Chou Shen et al.
BCO2 (β-carotene oxygenase 2) converts carotenoids into apocarotenoids by oxidative cleavage across double bonds and controls carotenoid homeostasis in vertebrate tissues. In this study, we examined BCO2's expression, localization, and act...
Pain and functional limitations in knee osteoarthritis are reflected in the fatty acid composition of plasma extracellular vesicles [0.03%]
膝骨关节炎的疼痛和功能障碍体现在血浆细胞外囊泡的脂肪酸组成中
Anne-Mari Mustonen,Petro Julkunen,Laura Säisänen et al.
Anne-Mari Mustonen et al.
This study investigated relationships between fatty acid (FA) profiles of extracellular vesicles (EVs) and cartilage degradation, functional limitations, pain, and psychological well-being in knee osteoarthritis (KOA). Fasting plasma was co...
The influence of IMPDH activity on ciliogenesis and adipogenesis of 3T3-L1 cells while undergoing differentiation [0.03%]
IMPDH活性对3T3-L1细胞分化过程中纤毛生成和脂肪生成的影响
Kolsoom Shahdadnejad,Razieh Yazdanparast
Kolsoom Shahdadnejad
The functional roles of primary cilia and inosine 5'-monophosphate dehydrogenase (IMPDH) are among the hot topics in today's adipogenesis research. Considering the reported interaction between IMPDH and ADP Ribosylation Factor-Like GTPase 1...
What was the scientific context in which I wrote my 1975 "inositol phospholipids and cell surface receptor function" review? [0.03%]
我在1975年撰写关于“肌醇磷脂和细胞表面受体功能”的综述时，科学背景是什么？
Robert H Bob Michell
Robert H Bob Michell
50 years on from my BBA review, I was delighted to hear that many of the current leaders of research across "The Multiverse of Phosphoinositides" are contributing to an authoritative collection of articles on the current state of that cosmo...
RGFP966 inhibits palmitic acid induced VSMCs phenotypic transition by targeting ATGL [0.03%]
RGFP966通过靶向ATGL抑制棕榈酸诱导的血管平滑肌细胞表型转化
Siyi Zhang,Fangqin Nie,Youjie Zeng et al.
Siyi Zhang et al.
Background: The phenotypic switch of vascular smooth muscle cells (VSMCs) underlies the pathology of many cardiovascular diseases. Histone deacetylase 3 (HDAC3) is reported to upregulate in several cardiovascular diseases...
D-allulose enhances lipid oxidation in HepG2 cells via peroxisome proliferator-activated receptor α (PPARα) [0.03%]
D-阿洛酮糖通过过氧化物酶体增殖激活受体α增强HepG2细胞脂质氧化作用
Firas Warda,Jennifer Batch,Lauren Graham et al.
Firas Warda et al.
Lipid accumulation in hepatocytes in non-alcoholic steatohepatitis (NASH) is attributed partly to loss of insulin-responsiveness and/or an increased pro-inflammatory state. Since the rare sugar D-allulose has insulin mimetic and anti-inflam...
Metabolomic and gene networks approaches reveal the role of mitochondrial membrane proteins in response of human melanoma cells to THz radiation [0.03%]
代谢组学和基因网络方法揭示线粒体膜蛋白在人类黑色素瘤细胞对太赫兹辐射反应中的作用
Ekaterina A Butikova,Nikita V Basov,Artem D Rogachev et al.
Ekaterina A Butikova et al.
Terahertz (THz) radiation has gained attention due to technological advancements, but its biological effects remain unclear. We investigated the impact of 2.3 THz radiation on SK-MEL-28 cells using metabolomic and gene network analysis. For...