Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance [0.03%]
Shewanella oneidensis中的多个KASIII同源物在脂肪酸合成起始和抗卡瑞烯素作用中的角色
Qiu Meng,Huihui Liang,Haichun Gao
Qiu Meng
It is fully established that the condensing reaction for the initiation of fatty acid synthesis is essential for viability of many bacteria. In model bacteria such as Escherichia coli, this reaction is exclusively catalyzed by β-ketoacyl-A...
Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization [0.03%]
激活细胞中磷脂酶A2选择性水解磷脂产生多不饱和脂肪酸的机制研究
Alma M Astudillo,María A Balboa,Jesús Balsinde
Alma M Astudillo
Phospholipase A2s are enzymes that hydrolyze the fatty acid at the sn-2 position of the glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of fatty acids within phospholipids, where saturated fatty acids t...
Group 1B phospholipase A2 in metabolic and inflammatory disease modulation [0.03%]
ⅠB组磷脂酶A2在代谢及炎症性疾病中的作用机制研究进展
David Y Hui
David Y Hui
The group 1B phospholipase A2 (PLA2G1B) is a secreted phospholipase that catalyzes the hydrolytic removal of the sn-2 fatty acyl moiety from phospholipids. This enzyme is synthesized most abundantly in the pancreas and is also expressed in ...
Schizosaccharomyces pombe cardiolipin synthase is part of a mitochondrial fusion protein regulated by intron retention [0.03%]
裂殖酵母线粒体融合蛋白通过内含子保留受调节包括心磷脂合成酶
Veronika Virčíková,Lucia Pokorná,Dana Tahotná et al.
Veronika Virčíková et al.
Cardiolipin (CL) is a unique lipid component of mitochondria in all eukaryotes. It is important for the architecture of mitochondrial membranes and for mitochondrial dynamics. CL also creates a highly specific microenvironment of mitochondr...
Piero Pingitore,Stefano Romeo
Piero Pingitore
The human patatin-like phospholipase domain-containing 3 (PNPLA3) gene encodes for a protein of 481 amino-acids. The variant rs738409 is a cytosine to guanine substitution, encoding for the isoleucine to methionine substitution at position ...
Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation [0.03%]
遗传重构出一种新的假酵母极长链多不饱和磷脂分子并鉴定Cld1在缓解心磷脂过氧化效应中的新作用
Wenjia Lou,Hsiu-Chi Ting,Christian A Reynolds et al.
Wenjia Lou et al.
Cardiolipin (CL) is a unique phospholipid localized almost exclusively within the mitochondrial membranes where it is synthesized. Newly synthesized CL undergoes acyl remodeling to produce CL species enriched with unsaturated acyl groups. C...
Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids [0.03%]
大肠杆菌心磷脂合酶具有内源性和外来性磷脂依赖的特异性磷酸脂肪酶D活性
Aike Jeucken,J Bernd Helms,Jos F Brouwers
Aike Jeucken
E. coli has three Cls-isoenzymes for cardiolipin (CL) synthesis but the differences between these three enzymes remain unresolved. All three Cls enzymes contain the phospholipase D (PLD) characteristic HKD motive and synthesize CL using PLD...
Cell proliferation and apoptosis inhibition: essential processes for recruitment of the full thermogenic capacity of brown adipose tissue [0.03%]
细胞增殖和凋亡抑制：棕色脂肪组织产热招募的两个重要过程
Jan Nedergaard,Yanling Wang,Barbara Cannon
Jan Nedergaard
In mice living under normal animal house conditions, the brown adipocytes in classical brown adipose tissue depots are already essentially fully differentiated: UCP1 mRNA and UCP1 protein levels are practically saturated. This means that an...
GD3 ganglioside-enriched extracellular vesicles stimulate melanocyte migration [0.03%]
GD3神经节苷脂富集的细胞外囊泡刺激黑色素细胞迁移
Andreia Hanada Otake,Renata de Freitas Saito,Ana Paula Marques Duarte et al.
Andreia Hanada Otake et al.
Melanomas often accumulate gangliosides, sialic acid-containing glycosphingolipids found in the outer leaflet of plasma membranes, as disialoganglioside GD3 and its derivatives. Here, we have transfected the GD3 synthase gene (ST8Sia I) in ...
Glucose-derived acetate and ACSS2 as key players in cisplatin resistance in bladder cancer [0.03%]
葡萄糖衍生的乙酸和ACSS2在膀胱癌顺铂耐药中的关键作用
He Wen,Sujin Lee,Wei-Guo Zhu et al.
He Wen et al.
Cisplatin is an important chemotherapeutic agent against metastatic bladder cancer, but resistance often limits its usage. With the recent recognition of lipid metabolic alterations in bladder cancers, we studied the metabolic implications ...