Calpain-1 is required for abnormality of liver function and metabolism in apolipoprotein E knockout mouse evaluated noninvasively by small animal MRI and PET-CT [0.03%]
小动物MRI和PET-CT无创评价技术在评估Apoe基因敲除鼠肝功能和代谢异常中的作用及钙蛋白酶-1的必要性研究
Mohamed Ali Awad,Wenjiao Gu,Shuangyi Li et al.
Mohamed Ali Awad et al.
We previously reported that calpain-1 knockout (KO) improved liver dysfunction in C57 mouse fed with high-fat diet (HFD). In the present study, Apolipoprotein E KO (ApoE KO) mouse was hybridized with calpain-1 KO mouse to obtain ApoE/calpai...
Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities [0.03%]
磷脂酰肌醇-4-磷酸：小体内的千面人生
Tamas Balla
Tamas Balla
Phosphorylated products of phosphatidylinositol (PI), named Diphosphoinositide (DPI) and triphosphoinositide (TPI) were identified long time ago and found to exhibit high turnover rates based on their rapid 32P-phosphate labeling. The PI ki...
Measurement of skin carotenoids and their association with diseases: a narrative review [0.03%]
皮肤类胡萝卜素的测定及其与疾病的关系：综述文章
Akira Obana
Akira Obana
Skin carotenoids are highly correlated with blood carotenoid concentrations and can be measured noninvasively using optical methods. Skin carotenoid levels are widely used in nutritional education as indicators of fruit and vegetable intake...
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway [0.03%]
phlorizin载药脂质体通过调节炎症及Nrf2信号通路促进颈动脉粥样硬化修复
Xiaoyu Wu,Chuanbo Ding,Xinglong Liu et al.
Xiaoyu Wu et al.
Carotid atherosclerosis (CAS) is a complex cardiovascular disease linked to inflammatory response and oxidative stress. This study aimed to develop and assess the therapeutic efficacy of Phlorizin liposomes (Phlorizin-Lips) in repairing CAS...
Phosphatidylethanolamine species with n-3 and n-6 fatty acids modulate macrophage lipidome and attenuate responses to LPS stimulation [0.03%]
含n-3和n-6脂肪酸的磷脂乙醇胺通过调节巨噬细胞脂质组分减轻LPS刺激反应
Tatiana Maurício,Inês M S Guerra,Marisa Pinho et al.
Tatiana Maurício et al.
Phospholipids are increasingly recognized as key regulators of biological processes, including macrophage polarization and function. Among these, phosphatidylethanolamine (PE), a major constituent of cell membranes, is pivotal in maintainin...
The synthetic TRPML1 agonist ML-SA1 mitigates intracellular lipid accumulation induced by antipsychotics in vitro by stimulating release of extracellular microvesicles [0.03%]
合成TRPML1激动剂ML-SA1通过刺激细胞外微囊分泌减轻抗精神病药物诱导的体内细胞内脂质聚集作用研究
Irene Chavarría-Cubel,Yessenia L Molina,Bohdan Babiy et al.
Irene Chavarría-Cubel et al.
Antipsychotics drugs disrupt lipid homeostasis by inhibiting cholesterol biosynthesis and impairing intracellular cholesterol trafficking, leading to lipid accumulation in endolysosomes. Moreover, transient receptor potential mucolipin 1 (T...
Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement [0.03%]
细胞骨架通过控制脂滴运动调节脂滴融合及脂肪蓄积
Yan Liang,Zanzan Zhu,Yiming Lu et al.
Yan Liang et al.
Lipid droplets (LDs) are highly dynamic organelles that maintain cellular lipid homeostasis through size and number control. In adipose tissue, CIDEC plays a crucial role in LD fusion and lipid homeostasis. However, the regulatory factors a...
Lipid metabolism associated PLPP4 gene drives oncogenic and adipogenic potential in breast cancer cells [0.03%]
与乳腺癌细胞致癌和成脂潜能相关的脂质代谢相关PLPP4基因
Sneha Soni,Sweta H Makwana,Shivani Bansal et al.
Sneha Soni et al.
Lipid metabolic reprogramming plays a pivotal role in cancer cell evolution and causing subsequent cancer growth, metastasis and therapy resistance. Cancer associated adipocyte and/or cancer derived adipocyte-like cells often supply fuels a...
Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation [0.03%]
磷脂酰乙醇胺代谢的改变影响肝细胞的脂质储存、能量稳态和增殖
Courtney M Holdaway,Kelly-Ann Leonard,Randal Nelson et al.
Courtney M Holdaway et al.
Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in eukaryotic membranes and is involved in several cellular processes. An important pathway for de novo PE synthesis is the Kennedy Pathway. The rate limiting enz...
Walnut oil as a dietary intervention for atherosclerosis: Efficacy and mechanistic pathways [0.03%]
核桃油作为动脉粥样硬化的饮食干预措施：功效及机制路径
Shujuan Hu,Si Tang,Dang Liu et al.
Shujuan Hu et al.
Background and aims: Walnut oil (WO) and peanut oil (PO) are common vegetable oils rich in unsaturated fatty acids, known to alleviate atherosclerosis (AS) and reduce the risk of cardiovascular diseases (CVD). WO contains...