Androgen regulates seasonal changes in triglyceride synthesis through the AR-SREBP1-FASN axis in the scented glands of muskrats (Ondatra zibethicus) [0.03%]
雄激素通过AR-SREBP1-FASN轴调节麝鼠（Ondatra zibethicus）香腺内三酰甘油合成的季节性变化
Xinjing Shi,Qingjing Gao,Wenjing Lu et al.
Xinjing Shi et al.
SREBP1 (sterol regulatory element binding protein 1) plays an important role in maintaining lipid balance in mammals. Previous research showed that androgen significantly regulated the secretion of lipid-rich musky odor substances from the ...
Endogenous synthesis of n-3 PUFAs can reduce lipid synthesis in Fad3 transgenic cattle [0.03%]
内源合成n-3 PUFA可降低转基因fad3牛的脂质合成
Danyi Li,Yuxin Gao,Xiaoyu Zhao et al.
Danyi Li et al.
n-3 polyunsaturated fatty acids (PUFAs) play important roles in the health, development and growth of mammals. However, most mammals, including humans, cannot synthesize n-6 and n-3 PUFAs and can only obtain them from the diet. The fatty ac...
Acetyl-CoA acyltransferase 2 as a metabolic modulator: Unraveling its impact on hepatic lipid dynamics in chicken embryos [0.03%]
乙酰辅酶a酰基转移酶2作为代谢调节因子：其对鸡胚胎肝脂代谢的影响研究
Mengling Peng,Luyao Kan,Xinyu Zhao et al.
Mengling Peng et al.
Despite the established role of acetyl-CoA acyltransferase 2 (ACAA2) in hepatic lipid homeostasis in mammals, its function in regulating hepatic lipid metabolism during the embryonic stage of chickens remains unexplored. This study aimed to...
Different effects of Lorenzo's oil components against very long-chain fatty acid-induced endoplasmic reticulum stress in peroxisome-deficient CHO cells [0.03%]
橄榄油成分对抗极长链脂肪酸诱导的过氧化物酶体缺陷CHO细胞内质网应激的不同的效应
Hanif Ali,Mone Yamanishi,Rumana Yesmin Hasi et al.
Hanif Ali et al.
Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder caused by mutations in the ABCD1 gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). The accumulation of saturated VLCFAs, such as C24:0 and C26:0, is bel...
Håvard S Haukaas,Harald Stenmark
Håvard S Haukaas
Membrane contact sites (MCSs) between the different compartments of the cell play important roles in lipid, protein and ion transfer. Phosphoinositides are crucial for the functions of many MCSs, either as membrane anchors for MCS proteins,...
Mateusz Kondratowicz,Ambroise Wu,Ewa Grela et al.
Mateusz Kondratowicz et al.
The plasma membrane, composed mostly of lipids and proteins, is a dynamic structure essential for maintaining cellular homeostasis and signaling. Its composition, organization and molecular dynamics have important functional consequences fo...
Control of ALOX5 expression in monocytic cells using a synthetic riboswitch [0.03%]
利用合成核糖开关控制单核细胞中ALOX5的表达
Robin W Bruckhoff,Julia H Oberlis,Dieter Steinhilber et al.
Robin W Bruckhoff et al.
The human 5-lipoxygenase (5-LOX), which is encoded by the arachidonate 5-lipoxygenase (ALOX5) gene, has its canonical function in leukotriene (LT) biosynthesis, which controls inflammatory and allergic responses. Besides oxylipin formation ...
Polyunsaturated fatty acids in kidney diseases: Navigating the fine line between healing and damage [0.03%]
多不饱和脂肪酸与肾脏疾病：治疗与损伤之间的微妙平衡
Mehrdad Aghasizadeh,Ahmad Reza Bahrami,Maryam M Matin
Mehrdad Aghasizadeh
Polyunsaturated fatty acids (PUFAs) regulate renal inflammation through metabolites generated by COX, LOX, and CYP pathways. While prostaglandins, leukotrienes, and 20-hydroxyeicosatetraenoic acid (20-HETE) exacerbate kidney injury, epoxyei...
Effect of α-ketoglutarate on maternal lipid homeostasis and mitochondrial status perturbed by gestational arsenic exposure [0.03%]
α-酮戊二酸改善母体砷暴露造成的脂代谢紊乱及线粒体损伤效应研究
Tong Zhan,Shuang-Rui Bao,Ying Sun et al.
Tong Zhan et al.
Arsenic is a common environmental toxicant with known hepatotoxic effects, yet its impact on maternal lipid metabolism during pregnancy remains poorly understood. In this study, we established a pregnant mouse model to investigate the effec...
Linarin alleviates high-fat diet-induced NAFLD via modulating the PI3K/Akt/mTOR pathway, autophagy, and gut microbiota [0.03%]
通过调节PI3K/Akt/mTOR途径、自噬和肠道微生物群，Linarin缓解高脂饮食引起的NAFLD
Mengfan Lv,Yaxin Zhai,Hao Yu et al.
Mengfan Lv et al.
Linarin (Lin) is a flavonoid compound widely found in traditional herbal medicines and is recognized for its diverse biological properties, including anti-inflammatory, analgesic, antioxidant, hepatoprotective, and anti-apoptotic effects. N...