Nano-curcumin mitigates muscle impairment in hypoxic hindlimb-unloaded mice [0.03%]
纳米姜黄素可减轻缺氧引起的载荷不足小鼠的肌肉损伤
Rizwan Qaisar,Saeed Ahmad Khan,Mutasem Rawas-Qalaji et al.
Rizwan Qaisar et al.
Background: Skeletal muscle atrophy due to hindlimb unloading (HU) is worsened under hypoxic conditions, mimicking clinical scenarios such as prolonged bed rest and chronic cardiopulmonary disease. Curcumin has therapeuti...
Thoracic aortic aneurysm and dissection: Similarities, differences and pharmacotherapy [0.03%]
胸部主动脉瘤和夹层：相似性、差异及药物治疗
Yan-Ni Hu,Mi Wang,Zheng Zhang
Yan-Ni Hu
Aortic aneurysms and aortic dissections are major diseases affecting the thoracic aorta, with high morbidity and mortality. Thoracic aortic aneurysm (TAA) is characterized by bulge in the weakened aortic wall, which is usually asymptomatic ...
Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability [0.03%]
circRNA Circ_0075691通过与EIF4A3互作调节颗粒细胞内PTGS2 mRNA稳定性来调控脂质代谢
Pengyu Huang,Jianshu Cai,Gangxin Chen et al.
Pengyu Huang et al.
Background: Circular RNAs (circRNAs) are implicated in polycystic ovary syndrome (PCOS), yet their roles in granulosa cell dysfunction remain unclear. This study explores the mechanistic role of circ_0075691 in PCOS-assoc...
ATP6V0d2 alleviates acute liver injury via promoting hepatocyte autophagy [0.03%]
ATP6V0d2通过促进肝细胞自噬缓解急性肝损伤
Mengxia Zhang,Zhemin Shi,Yi Yang et al.
Mengxia Zhang et al.
Liver injury is the pathological basis of various liver diseases, and severe acute liver injury can progress to acute liver failure with a high mortality. Although continuous progress has been made over the past few decades, the molecular m...
Mitigating loss of lean muscle in GLP-1 and dual GLP-1/GIP agonists: Pipeline opportunities and limitations [0.03%]
GLP-1和双GLP-1/GIP受体激动剂减轻肌肉损耗：机遇与局限性
Justin Hierholzer,Harrison Benson,Heba A Ewida et al.
Justin Hierholzer et al.
Glucagon-like peptide-1 (GLP-1) receptor and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonists drive significant transformation in the landscape for type 2 diabetes and obesity management, yet 15-40% of weight loss in t...
Goosecoid promotes hepatic stellate cell epithelial-mesenchymal transition via transcriptional activation of serum- and glucocorticoid-induced protein kinase 1 in liver fibrosis [0.03%]
Goosecoid通过转录激活血清和糖皮质激素诱导的蛋白激酶1促进肝星状细胞上皮间质转化以治疗肝纤维化
Yongjuan Wang,Xiaoli Xie,Jiajun Tian et al.
Yongjuan Wang et al.
Background: Goosecoid (GSC) is a transcription factor implicated in epithelial-mesenchymal transition (EMT) during embryogenesis and cancer, but its function in organ fibrosis remains poorly understood. This study investi...
Multimodal psychological intervention improves psychological well-being and inflammatory profiles in patients with diabetic nephropathy [0.03%]
多模式心理干预可改善糖尿病肾病患者的心理健康和炎症指标
Hangyan Tang,Shengquan Liu
Hangyan Tang
Patients with diabetic nephropathy (DN) often experience negative emotions and a decline in quality of life, conditions in which the neuro-endocrine-immune axis plays a crucial role. In this study, we explored the effects of an eight-week m...
Placental aberrant inflammation and spatial-specific lipid metabolism contribute to hypertensive disorder of pregnancy susceptibility in preeclampsia offspring [0.03%]
胎盘异常炎症和空间特异性脂质代谢贡献了子痫前期后代患妊娠高血压疾病的易感性
Pei-Ran Hu,Jing-Hui Xu,Yan Shi et al.
Pei-Ran Hu et al.
Epidemiological studies have demonstrated that daughters of preeclamptic mothers have an increased risk of hypertensive disorders of pregnancy (HDP), but the underlying mechanisms remain unclear. To investigate the molecular changes underly...
Berbamine attenuates acetaminophen-induced liver injury by engaging GCLC and enhancing ferroptosis-regulatory antioxidant pathways [0.03%]
延胡索乙素通过激活GCLC和增强铁死亡调控的抗氧化通路抑制对乙酰氨基酚致肝损伤
Mengli Tao,Jiayi Shi,Yingying Zhang et al.
Mengli Tao et al.
Objective: Acetaminophen (APAP)-induced liver injury (ALI), the major cause of acute drug-induced hepatotoxicity, lacks effective therapies. Berbamine (BBM), a bisbenzylisoquinoline alkaloid derived from the genus Berberi...
SIRT5 promotes vascular regeneration in peripheral muscle ischemia by regulating malonylation and glycolysis [0.03%]
SIRT5通过调控琥珀酰化和糖酵解促进外周肌肉缺血的血管再生
Kanghui Chen,Hang Chen,Peng Wang et al.
Kanghui Chen et al.
Peripheral artery disease (PAD) is a prominent contributor to the global prevalence and mortality of cardiovascular diseases, yet the therapeutic strategies remain limited and urgently to explore the new methods of promoting vascular regene...