Knock-in reporter constructs and drug screening for compounds to restore RKIP expression in cancer [0.03%]
用于恢复癌症中RKIP表达的化合物的报告基因插入构建和药物筛选
Sawssen Bouali,Xunzhen Zheng,Chris Figy et al.
Sawssen Bouali et al.
RKIP (Raf Kinaes Inhibitory Protein) is ubiquitously expressed in almost all normal tissues of metazoans. Consistent with its negative regulatory role in cell proliferation and survival, RKIP expression is progressively downregulated in can...
Oncogenic epigenetic factor EP300 is a potential therapeutic target for bladder carcinoma [0.03%]
致癌表观遗传因子EP300可能是膀胱癌的潜在治疗靶点
Qing Zhang,Yingzhou Hong,Chongjie He et al.
Qing Zhang et al.
Bladder cancer remains a major cause of global mortality with limited therapies. Here, we reported that epigenetic regulator EP300 acts as oncogenic role in bladder cancer. Public data show EP300 mutations correlated with better prognosis, ...
Adipose-derived mesenchymal stem cell exosomes enhance diabetic wound healing via the amelioration of fibroblast senescence through the SMARCAL1-Drp1 signaling pathway [0.03%]
脂肪源性间充质干细胞外泌体通过SMARCAL1-Drp1信号通路改善成纤维细胞衰老以促进糖尿病伤口愈合
Hang Wu,Xuan Jiang,Jieyun Cai et al.
Hang Wu et al.
Delayed healing of diabetic wounds (DW) represents a significant complication among diabetic patients, for which current therapeutic approaches remain suboptimal. Accumulating evidence indicates that fibroblast senescence plays a critical r...
12,13-diHOME ameliorates MASLD by regulating Sestrin2-mediated AMPK/ULK1/Lipophagy in obese mice [0.03%]
12,13-二羟基十八碳四烯酸通过调节肥胖小鼠中的Sestrin2介导的AMPK/ULK1/Lipophagy改善MASLD
Kexin Zhang,Chengxia Kan,Hongyan Qiu et al.
Kexin Zhang et al.
Obesity-driven metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by hepatic lipid accumulation and impaired lipid metabolism. Enhancing lipophagy, the autophagic degradation of lipid droplets, represents a pr...
Dapagliflozin targets RORγt to improve myocardial ischemia-reperfusion injury-induced heart failure by regulating the CD4+ T cell/Th17 cell axis within cardiac tissue [0.03%]
达格列净通过调节心脏组织中CD4⁺T细胞/Th17细胞轴靶向RORγt来改善心肌缺血再灌注损伤诱导的心力衰竭
Yan Wu,Xuewan Ge,Dongbiao Yu et al.
Yan Wu et al.
Dapagliflozin (DAPA) is the first sodium-glucose cotransporter 2 (SGLT2) inhibitor to receive approval for clinical use in China. However, the mechanism behind the cardioprotective effects of DAPA remains unclear, as cardiac tissue does not...
Vesicular nucleotide transporter (VNUT)-dependent ATP secretion by hepatic stellate cells promotes liver fibrosis [0.03%]
肝星状细胞依赖性囊泡核苷酸转运体(VNUT)的ATP分泌促进肝纤维化
Masaharu Kabashima,Nao Hasuzawa,Lixiang Wang et al.
Masaharu Kabashima et al.
Although liver fibrosis presents a substantial global health challenge, therapeutic options that directly target liver fibrosis remain limited. Hepatic stellate cells (HSCs) are key contributors to fibrosis through extracellular matrix prod...
Glucosamine suppresses hepatocellular carcinoma progression through dual inhibition of cell cycle progression and nucleotide metabolism [0.03%]
葡萄糖胺通过双重抑制细胞周期进程和核苷酸代谢来抑制肝癌进展
Yan-Lai Zhang,Jia-Xin Yin,Qun Liu et al.
Yan-Lai Zhang et al.
Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver cancer with limited treatment options and poor prognosis. Glucosamine (GlcN), a widely used dietary supplement, demonstrates anti-inflammatory properties but its antitumor p...
HER2-dependent paraptosis and ferroptosis induction by cannabidiol in breast cancer cells [0.03%]
大麻二酚诱导乳腺癌细胞中依赖于 HER2 的类凋亡和铁死亡作用
Na Young Kim,Mina Lee,Yejin Hong et al.
Na Young Kim et al.
HER2 (human epidermal growth factor receptor 2) is a well-established oncogenic driver and therapeutic target in breast cancer. Cannabidiol (CBD), a non-psychoactive phytocannabinoid, has demonstrated anticancer potential, yet its mechanism...
Leveraging macrophage plasticity for precision-targeted tumor immunotherapy [0.03%]
利用巨噬细胞的可塑性进行精准靶向肿瘤免疫治疗
Shu-Jin Li,Xiao-He Wang,Ling-Rui Li et al.
Shu-Jin Li et al.
While immunotherapy has demonstrated remarkable therapeutic potential in certain malignancies, its overall clinical efficacy remains suboptimal. Emerging evidence indicates that the tumor microenvironment (TME) plays a pivotal role in deter...
Tumor-derived ITIH2 activates PI3K/AKT pathway via THBS1 ubiquitination and promotes tumor angiogenesis in hepatocellular carcinoma [0.03%]
肝细胞癌中肿瘤衍生的ITIH2通过THBS1泛素化激活PI3K / AKT途径并促进肿瘤血管生成
Zijian Liu,Jingsheng Yuan,Qiwen Zeng et al.
Zijian Liu et al.
The heterogeneous tumor microenvironment (TME) plays a critical role in the initiation and progression of hepatocellular carcinoma (HCC). Within the TME, tumor vascular endothelial cells (ECs) are key stromal components that drive angiogene...