Developmental DVE-1 programs ACT-5-dependent microvillar organization to preserve intestinal homeostasis in C. elegans [0.03%]
发育中的DVE-1程序化ACT-5依赖的微绒毛排列以在秀丽隐杆线虫中维持肠上皮稳态
Liuqingqing Yang,Jiahui Liu,Shuqi Guo et al.
Liuqingqing Yang et al.
The intestinal epithelium balances nutrient absorption and barrier defense using its apical brush border. Disrupting this structure causes malabsorption and disease, but the transcriptional programs driving its formation remain unclear. Her...
Eicosanoids in lung cancer: Mechanisms, metabolism, and therapeutic potential [0.03%]
肺癌中的二十烷衍生物：机制、代谢及治疗潜力
Woo Hyun Park
Woo Hyun Park
Lung cancer is the leading cause of cancer-related mortality worldwide, and its pathogenesis is intricately associated with chronic inflammation and metabolic reprogramming. Eicosanoids, a diverse class of lipid mediators derived predominan...
Raman spectroscopic characterization of protein changes induced by 5-fluorouracil in colon cancer cells [0.03%]
5-氟尿嘧啶诱导的结肠癌细胞内蛋白质变化的拉曼光谱分析
Monika Kopeć,Karolina Beton-Mysur,Anna Sroka-Bartnicka et al.
Monika Kopeć et al.
This paper aims to evaluate the current state of knowledge on understanding the impact of cytostatic on colon cancer progression. We have compared the Raman profile of the normal colon fibroblast cell line (CCD-18Co) and two colon epithelia...
Extracellular vesicles in tumor immune escape and therapeutic resistance: mechanisms and immunopharmacological opportunities [0.03%]
肿瘤免疫逃逸和治疗抵抗的细胞外囊泡机制及免疫药理学机遇
Zhehao Xiao,Ziman Luo,Lijun Chen et al.
Zhehao Xiao et al.
Extracellular vesicles (EVs) are key mediators of intercellular communication in cancer. In this review, we focus on how EVs mechanistically link tumor immune escape with therapeutic resistance and how these insights may be translated into ...
Curcumin suppresses HNSCC tumorigenesis through directly targeting FOSL1/JUN [0.03%]
姜黄素通过直接作用于FOSL1 / JUN抑制头颈鳞状细胞癌的肿瘤发生
Jerry Li,Sarita Pandit,Kanakaraju Manupati et al.
Jerry Li et al.
Natural products and affordable herbal medications have emerged as promising alternatives for cancer therapy, particularly for patients with limited access to standard treatments. Among these, curcumin, the bioactive polyphenol from Curcuma...
Temporal gene expression profiling reveals the protective mechanism of APIP in atrial fibrillation following myocardial infarction [0.03%]
时间基因表达谱分析揭示了心肌梗死后房颤的保护机制(APIP)
Yun-Long Zhang,Tang-Na Chen,Jia-Kang He et al.
Yun-Long Zhang et al.
Background: Atrial fibrillation (AF), the most prevalent form of cardiac arrhythmia, frequently develops as a complication of acute myocardial infarction (MI). Nonetheless, the temporal dynamics of gene expression and key...
Mechanism of Helicobacter pylori-induced FOXO3a ubiquitination and degradation in gastric epithelial cells by modifying YWHAZ through B4GALT5-mediated glycosylation during gastric carcinogenesis [0.03%]
胃癌发生过程中B4GALT5介导的糖基化通过修饰YWHAZ诱导胃上皮细胞FOXO3a泛素化和降解的机制研究
Wenbin Tuo,Zilu Qu,Tian Xiang et al.
Wenbin Tuo et al.
Background: Abnormal glycosylation modifications are pivotal in tumorigenesis. However, the mechanism by which Helicobacter pylori (H. pylori) infection affects glycosylation during gastric cancer (GC) progression is not ...
ZNF750 loss defines an ESCC subtype with constitutive NF-κB activation and vulnerability to bortezomib [0.03%]
ZNF750丢失定义了一种具有构成型NF-κB激活和硼替佐米易感性的食管鳞癌亚型
Yanghui Bi,Mengyao Wang,Yong Zhang et al.
Yanghui Bi et al.
Background: Esophageal squamous cell carcinoma (ESCC) lacks effective targeted therapies. The tumor suppressor ZNF750 is frequently inactivated, yet the primary mechanism and its therapeutic implications remain poorly def...
Schisandrin A inhibits head and neck squamous cell carcinoma progression via the PI3K/AKT/GSK3β pathway [0.03%]
五味子素A通过PI3K/AKT/GSK3β信号通路抑制头颈鳞状细胞癌的发展
Han-Yu Wu,Wen-Jing Wang,Qian Lin et al.
Han-Yu Wu et al.
Background: Head and neck squamous cell carcinoma (HNSCC) is a major public health concern with limited effective therapeutic options. There is an urgent need to identify novel, safe, and efficacious treatments for this a...
Targeted inhibition of the H3K27ac/OGT/O-GlcNAcylation axis to overcome gemcitabine-induced chemotherapy resistance in bladder cancer [0.03%]
靶向抑制H3K27ac/OGT/O-GlcNA酰化轴以克服吉西他滨诱导的膀胱癌化疗耐药性
Zhijuan Liang,Liping Wang,Dan Li et al.
Zhijuan Liang et al.
Gemcitabine (Gem), a primary treatment for advanced and metastatic bladder cancer, can lead to malignant progression and drug resistance, though the underlying mechanisms are not fully understood. Post-translational modifications (PTMs) are...