NSUN2 as a therapeutic target: Modulating tumor growth and immune microenvironment in colon adenocarcinoma [0.03%]
NSUN2作为治疗靶点：调节结肠腺癌的肿瘤生长及免疫微环境
Yuchen Wen,Mengjun Huang,Haoyu Fu et al.
Yuchen Wen et al.
Elevated expression of the RNA methyltransferase NSUN2 is significantly associated with advanced disease progression and shorter overall survival in colorectal adenocarcinoma (COAD), underscoring its clinical relevance. To elucidate the fun...
Ferroptosis-driven coronary plaque vulnerability: A tandem mechanism involving endothelial cells, macrophages, and smooth muscle cells [0.03%]
铁死亡驱动的冠状动脉斑块易损性：内皮细胞、巨噬细胞和平滑肌细胞的串联机制
Youqi Zhu,Zhicong Gu,Yurun Su et al.
Youqi Zhu et al.
The formation and progression of vulnerable plaques constitute the pathological basis of coronary atherosclerotic heart disease. Ferroptosis, an iron-dependent non-apoptotic form of programmed cell death, has emerged as an important contrib...
Dysregulation of the CUL2-Sirt2 axis exacerbates lung epithelial barrier injury in Staphylococcus aureus-induced pneumonia [0.03%]
CUL2-Sirt2轴的调控紊乱会加重金黄色葡萄球菌肺炎引起的肺上皮屏障损伤
Xiangyu Zhou,Zhuyun Zhao,Ke Wang
Xiangyu Zhou
Background: Staphylococcus aureus infection can cause severe lung injury and inflammation, with mechanisms including excessive activation of the NF-κB pathway and disruption of the epithelial barrier. The role of host re...
H3K27ac-induced IFITM3 promotes progression of TNBC and resistance to anti-PD-1/PD-L1 therapy via the TNF-α/NF-κB/PD-L1 axis [0.03%]
H3K27ac诱导的IFITM3通过TNF-α/NF-κB/PD-L1轴促进三阴性乳腺癌的发展和抗PD-1 / PD-L1疗法的耐药性
Guangyan Li,Baiyang Fu,Xi Wang et al.
Guangyan Li et al.
Triple-negative breast cancer (TNBC) is highly malignant with limited effective targeted therapies, leading to poor patient outcomes. Although immune checkpoint inhibitors (ICIs) have shown promise in cancer treatment, most patients with TN...
USP47 alleviates metabolic-associated fatty liver disease by activating the PPARα signaling pathway through the stabilization of SIRT1 [0.03%]
USP47通过稳定SIRT1激活PPARα信号通路从而缓解代谢相关脂肪性肝病
Ya Cao,Zhengrong Wen,Jiachuan Chen et al.
Ya Cao et al.
Background: Metabolic-associated fatty liver disease (MAFLD) is a common chronic liver disease caused by lipid accumulation in hepatocytes, and multiple deubiquitinating enzymes (DUBs) have been reported to play roles in ...
Ubiquitin-like modifications in adipose tissue development and obesity: New insights [0.03%]
泛素样修饰在脂肪组织发育和肥胖中的作用：新见解
Shayantani Chakraborty,Weiqin Chen
Shayantani Chakraborty
Obesity involves abnormal adipose tissue remodeling, including increased fat cell number (hyperplasia) and size (hypertrophy), along with dysregulated adipogenesis, function, and turnover of white, beige, and brown fat cells. These changes ...
Systemic review of commonly used hyperuricemia models: From bench to preclinical studies [0.03%]
高尿酸血症常用模型的系统性评述：从实验研究到临床前试验
Chuanli Hou,Kaiqiang Li,William Kwame Amakye et al.
Chuanli Hou et al.
Reliable hyperuricemia models are fundamental for investigating disease mechanisms and evaluating pharmaceuticals as well as food-derived bioactive compounds with therapeutic potential. A variety of experimental models have been established...
Revisiting the NETs-CYBB-p38 MAPK axis in bronchiectasis: The underlying oxidative injury mechanism [0.03%]
重新审视NETs-CYBB-p38 MAPK轴在支气管扩张中的作用：潜在的氧化损伤机制
Shaochu Zheng,Jinling Tang,Xiaopu Wu et al.
Shaochu Zheng et al.
Background: Bronchiectasis is a chronic neutrophilic respiratory disease frequently complicated by Pseudomonas aeruginosa (P. aeruginosa) infection. Neutrophil extracellular traps (NETs) exert dual effects in host defense...
TIMM23-ERAL1 Axis: A novel regulator of mitochondrial apoptosis in hepatocellular carcinoma [0.03%]
TIMM23-ERAL1轴在肝细胞癌线粒体凋亡中的作用与机制研究
Yihong Chen,Qiyi Qian,Juejiashan Li et al.
Yihong Chen et al.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy of the digestive system characterized by increasing global incidence and mortality rates. Translocase of the Inner Mitochondrial Membrane 23 (TIMM23), a key component of the m...
Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress [0.03%]
乌头毒碱通过激活p38MAPK途径上调CHOP并诱导内质网应激来抑制胰腺癌进展
Mengyao Tian,Xuehui Wang,Wangyang Chen et al.
Mengyao Tian et al.
Pancreatic cancer (PC) remains among the most lethal gastrointestinal malignancies and is characterized by poor prognosis and limited therapeutic options. The discovery of natural antitumor compounds from traditional Chinese medicine has em...