DNMT3B attenuates the development of thoracic aortic aneurysm and dissection by suppressing TFEB-mediated autophagy in vascular smooth muscle cells [0.03%]
DNA甲基化转移酶DNMT3B通过抑制血管平滑肌细胞中TFEB介导的自噬来预防胸主动脉瘤和夹层的发生发展
Yulin Bao,Yaxin Zhu,Yuting Niu et al.
Yulin Bao et al.
While emerging evidence highlights the importance of DNA methyltransferase 3B (DNMT3B) in cardiovascular pathophysiology, its precise role in thoracic aortic aneurysm and dissection (TAAD) remains poorly understood. Here, we elucidate the f...
The irisin-PINK1/Parkin axis plays an essential role in mediating microglial mitophagy: A crucial mechanism for exercise-induced neuroprotection against Parkinson's disease [0.03%]
irisin-PINK1/Parkin轴在调节小胶质细胞自噬中发挥重要作用：运动介导的帕金森病神经保护的关键机制
Bin Wang,Xin Liu,Xin Tian et al.
Bin Wang et al.
The progression of Parkinson's disease (PD) is primarily driven by chronic neuroinflammation in microglia and impaired mitochondrial quality control. Here, we show that 10 weeks of treadmill running ameliorates motor deficits, dopaminergic ...
Key module genes in proximal tubular cells drive microenvironmental chronic inflammation and fibrosis in diabetic kidney disease: A single-cell transcriptomic study [0.03%]
单细胞转录组学揭示近端小管细胞关键模块基因驱动糖尿病肾脏疾病微环境慢性炎症和纤维化
Wenjing Zhou,Zhaogui Chen,Guanghui Ying et al.
Wenjing Zhou et al.
Diabetic kidney disease (DKD) is one of the most severe microvascular complications of diabetes, with proximal tubular (PT) epithelial cells playing a pivotal role in its progression, yet the underlying dynamic molecular mechanisms remain u...
The CFIm25/FDPs axis orchestrates protective mitophagy in macrophages to attenuate myocardial infarction [0.03%]
CFIm25/FDPs轴通过在巨噬细胞中诱导保护性线粒体自噬从而减轻心肌梗死病情恶化症状
Ye Zhou,Yi Li,Meng Liu et al.
Ye Zhou et al.
Alternative cleavage and polyadenylation (APA) is a major post-transcriptional regulatory mechanism that is frequently dysregulated following myocardial infarction (MI). To investigate its role in post-infarction remodeling, we focused on t...
Roles of cholesteryl α-glucosides produced by Helicobacter pylori in the interactions with the host immune system [0.03%]
胆固醇葡萄糖苷通过霍乱弧菌在宿主免疫系统中的作用研究及其对胃癌影响的研究之二:胆固醇α-葡萄糖苷在霍乱弧菌与宿主免疫系统相互作用中的作用
Michio Shimamura
Michio Shimamura
Helicobacter pylori extracts cholesterol from the host epithelial cells during infection for nutrition and lipid raft formation. However, the presence of cholesterol in invading bacteria facilitates phagocytosis and subsequent immune respon...
Synergistic apoptosis-sensitizing effect of PD-L1 inhibitor ARB-272572 encapsulated in TRAIL-expressing extracellular vesicles for renal cell carcinoma therapy [0.03%]
载有TRAIL表达的细胞外囊泡封装PD-L1抑制剂ARB-272572协同增强肾细胞癌凋亡敏感效应用于肾癌治疗
Ronghui Sun,Quanjiang Li,Jun Peng et al.
Ronghui Sun et al.
Renal cell carcinoma(RCC) is a therapy-resistant malignancy with rising global incidence, highlighting an urgent need for innovative treatments. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis i...
CNDP2 drives renal tubular fibrosis in diabetic kidney disease via a sulfur-containing amino acids-mTOR signaling axis [0.03%]
CNDP2通过含硫氨基酸-mTOR信号轴驱动糖尿病肾脏疾病中的肾小管纤维化
Yan Li,Qiao-An Zheng,Yan-Rong Chen et al.
Yan Li et al.
Background: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, with proximal tubule fibrosis being a key pathological feature. Our previous study identified significant upregulation of cytosolic ...
The intratumoral microbiota: Orchestrating metabolic-immune crosstalk and shaping the therapeutic landscape in cancer [0.03%]
肿瘤微生物群：在癌症中调节代谢-免疫交叉对话和塑造治疗格局
Shilin Wang,Ziyi Liu,Chunyun Jiang et al.
Shilin Wang et al.
The intratumoral microbiota is now recognized as a key component of the tumor microenvironment, where it influences tumor metabolism, shapes immune activity, and modulates treatment responses. Microbial metabolites such as short-chain fatty...
Roshni Bibi,Swayamsiddhi,Subham Saishree et al.
Roshni Bibi et al.
Previous research shows that cancer vaccines hold great potential as immunotherapeutic agents which activate the body's tumor-cell elimination powers through immune recognition. Cancer vaccines encounter restricted success because of three ...
Yao Wang,Lei Wang,Sabine Ruf et al.
Yao Wang et al.
Orthodontically induced inflammatory root resorption (OIIRR) is a common complication associated with excessive compressive force during orthodontic treatment, leading to irreversible cementum destruction. However, the cellular and molecula...