HAO2 inhibits the growth and lipid metabolism of head and neck squamous cell carcinoma by enhancing MYH9 ubiquitination mediated by STUB1 and USP14 [0.03%]
HAO2通过增强STUB1和USP14介导的MYH9泛素化抑制头颈部鳞状细胞癌的生长和脂质代谢
Danqing Yan,Weilai Tong,Wei You et al.
Danqing Yan et al.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy globally, characterized by high invasiveness and poor prognosis. Over half of patients experience recurrence or metastasis within three years, underscoring th...
Targeting GHSR-1α with silibinin to enhance mitophagy and prevent tubular injury in diabetic kidney disease [0.03%]
靶向GHSR-1α利用异构体硅醇素促进线粒体自噬预防糖尿病肾病中的小管损伤
Nannan Zhang,Chao Chen,Lin Chen et al.
Nannan Zhang et al.
Diabetic kidney disease (DKD) remains a leading cause of global renal failure, with tubular injury driven by mitochondrial dysfunction representing a critical yet therapeutically unaddressed mechanism. Although the flavonolignan silibinin h...
KAT2B inhibits cholangiocarcinoma proliferation by binding with histone demethylase KDM6B [0.03%]
KAT2B通过与组蛋白去甲基化酶KDM6B结合抑制胆管癌增殖
Rongfang Qiu,Ziwei Xu,Hui Meng et al.
Rongfang Qiu et al.
Background: Cholangiocarcinoma is a highly malignant tumor of the biliary system with a poor prognosis. The epigenetic molecular mechanisms underlying its occurrence and progression remain unclear, and no effective molecu...
Molecular, cellular, and clinical aspects of myofibrillar myopathy caused by HSPB8 frameshift mutations [0.03%]
HSPB8 框移突变所致肌原纤维肌病的分子、细胞及临床特征分析
Wenli Zhou,Veronica Marchesi,Matthew McLeod et al.
Wenli Zhou et al.
HSPB8 belongs to the small heat shock protein family, which comprises ten chaperones with molecular weights below 29 kDa. HSPB8 is broadly expressed across human tissues, with the highest levels in skeletal muscles, the cardiac muscle, and ...
Rac1 promotes exosome secretion from proximal renal tubules to accelerate DKD [0.03%]
Rac1促进近端肾小管外泌体的释放以加速糖尿病肾病的发展
Meng Wang,Yanmeng Zhou,Ye Qian et al.
Meng Wang et al.
Chronic low-grade sterile inflammation is one hallmark of diabetic kidney disease (DKD). Exosomes secretion from renal cells plays an important role in the transmission of inflammatory substances, which is associated with DKD. Ras-related C...
Hepatic GAL1 deficiency alleviates steatosis via WWP2-mediated PARP1 degradation and activation of the SIRT1-CPT1A pathway [0.03%]
肝GAL1缺乏通过WWP2介导的PARP1降解和SIRT1-CPT1A途径活化缓解脂肪变性
Yuqi Li,Ruikai Li,Peng Wang et al.
Yuqi Li et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease worldwide and is closely associated with obesity, diabetes, and other metabolic disorders. Because M...
Dusp22 deficiency in cardiomyocytes exacerbates doxorubicin-induced cardiotoxicity by aggravating mitochondria-dependent apoptosis via JNK pathway [0.03%]
Dusp22缺乏通过加剧JNK介导的线粒体依赖性凋亡加重多柔比星引起的心肌细胞毒性
Miao Xiao,Bo Liao,Bo Zhou et al.
Miao Xiao et al.
The dose-cumulative cardiotoxicity of Doxorubicin (Dox) severely limits clinical anti-tumor treatment. Dual-specificity phosphatase 22 (DUSP22), which is expressed in various tissues, plays a key biological role in immune responses and tumo...
A Pumilio-dependent post-transcriptional mechanism drives pulmonary hypertension via KCNK3 suppression [0.03%]
Pumilio依赖的转录后机制通过KCNK3抑制驱动肺动脉高压
Xiaodong Deng,Faqi Zhu,Ying Guo et al.
Xiaodong Deng et al.
Pulmonary hypertension (PH) is a lethal vascular disorder characterized by obstructive remodelling of pulmonary arteries, driven predominantly by pathological phenotypes of pulmonary artery smooth muscle cells (PASMCs), including excessive ...
Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies [0.03%]
YAP1变异引起视盘发育异常的机制研究
Srishti Silvano,Van Annika Rick-Lenze,James Bagnall et al.
Srishti Silvano et al.
The conserved transcriptional co-activator YAP1 is a central regulator of organ development and tissue homeostasis, integrating mechanical and biochemical cues to control cell proliferation and survival. YAP1 variants underlie a spectrum of...
Sreelakshmi Vasudevan,Maya Tang,Paul S-H Park
Sreelakshmi Vasudevan
A C203R mutation in M-opsin is a cause of blue cone monochromacy (BCM) in human patients. The equivalent mutation in murine M-opsin is C198R since human M-opsin has an extra 5 amino acid residues in the amino terminal region that are not pr...