Thrombospondin-1-mediated crosstalk between autophagy and oxidative stress orchestrates repair of blast lung injury [0.03%]
血小板素1介导的自噬与氧化应激相互作用协调修复爆炸性肺损伤
Lin Zhang,Yongheng Wang,Linqiang Tian et al.
Lin Zhang et al.
Coal mining carries inherent risks of catastrophic gas explosions capable of inflicting severe lung injury. Using complementary in vivo and in vitro models, we explored mechanisms underlying alveolar epithelial damage and repair following a...
Elevated senescence in the bone marrow mesenchymal stem cells of acquired aplastic anemia patients: A possible implication of DNA damage responses and telomere attrition [0.03%]
获得性再生障碍性贫血患者骨髓间充质干细胞的衰老加速：DNA损伤反应和端粒消耗的一种可能含义
Pragati Saxena,Jyotika Srivastava,Bhuvnesh Rai et al.
Pragati Saxena et al.
Background: Bone marrow mesenchymal stem cells (BM-MSC) are an integral part of the BM niche that is essential to maintain hematopoietic homeostasis. In aplastic anemia (AA), a few studies have reported phenotypic defects...
A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy [0.03%]
稳定的肝脏特异性尿酸氧化酶基因敲除高尿酸血症小鼠模型发现肝源性嘌呤合成及尿酸肾病被激活
Lei Pang,Ningning Liang,Changgui Li et al.
Lei Pang et al.
Urate oxidase (Uox)-deficient mice could be an optimal animal model to study hyperuricemia and associated disorders. We develop a liver-specific conditional knockout Uox-deficient (UoxCKO) mouse using the Cre/loxP gene targeting system. The...
Immune infiltration related CENPI associates with the malignant features and drug resistance of lung adenocarcinoma [0.03%]
与免疫浸润相关的CENPI与肺腺癌的恶性特征和药物抵抗性相关
Ziyang Feng,Guangzu Cui,Jun Tan et al.
Ziyang Feng et al.
Centromere protein I (CENPI) is an important member of centromeric proteins family, which is crucial to chromosome alignment and segregation. Nevertheless, the interrelation between CENPI expression and tumor progression is in the shadows. ...
HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD [0.03%]
组蛋白去乙酰化酶9的抑制减轻了由香烟烟雾引起的COPD小鼠骨骼肌的萎缩并增强了其再生能力
Guixian Zheng,Chao Li,Xiaoli Chen et al.
Guixian Zheng et al.
Cigarette smoke (CS) is the major risk factor for chronic obstructive pulmonary disease (COPD), and sarcopenia is one of the significant comorbidities of COPD. However, the pathogenesis of CS-related deficient skeletal muscle regeneration h...
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy [0.03%]
IGF2BP3通过稳定CAMK1调节肾小管的线粒体动态平衡以缓解糖尿病肾病
Du Yuan,Hao Li,Wenni Dai et al.
Du Yuan et al.
Background: CAMK1 has been shown to be involved in human disease progression via regulating mitochondrial dynamics. However, whether CAMK1 mediates mitochondrial dynamics to regulate diabetic nephropathy (DN) process rema...
Gamut of glycolytic enzymes in vascular smooth muscle cell proliferation: Implications for vascular proliferative diseases [0.03%]
糖酵解酶类在血管平滑肌细胞增殖中的作用：对血管增生性疾病的意义
Ankan Sarkar,Sandip V Pawar,Kanwaljit Chopra et al.
Ankan Sarkar et al.
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the media of the blood vessels and are responsible for maintaining vascular tone. Emerging evidence confirms that VSMCs possess high plasticity. During vascular injury, V...
Dawn era for revisited cancer therapy by innate immune system and immune checkpoint inhibitors [0.03%]
利用固有免疫系统和免疫检查点抑制剂重启癌症治疗的黎明时代
Hee-Do Kim,Chia-Ying Yeh,Yu-Chan Chang et al.
Hee-Do Kim et al.
Immunotherapy is a promising therapeutic strategy for cancer. However, it shows limited efficacy against certain tumor types. The activation of innate immunity can suppress tumors by mitigating inflammatory and malignant behaviors through i...
Transcriptome analysis identifies genetic risk markers and explores the pathogenesis for inflammatory bowel disease [0.03%]
转录组分析确定基因风险标记并探索炎症性肠病的发病机制
Jiyan Wang,Mingming Sun,Xu Liu et al.
Jiyan Wang et al.
Inflammatory bowel disease (IBD) is an incurable and disabling bowel disease driven by multiple risk factors that severely limit patients' quality of life. We integrated the RNA-sequencing data of 1238 IBD patients, and investigated the pat...
Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation [0.03%]
髓样特异性删除组VIA钙独立磷脂酶A2通过MIP-1α激活在雄性小鼠中主要诱导促炎LPS反应
Lukas Klement,Chutima Jansakun,Bin Yan et al.
Lukas Klement et al.
Polymorphisms of group VIA calcium-independent phospholipase A2 (PLA2G6) are associated with blood C-reactive protein suggesting its role in inflammation. We showed that myeloid-specific Pla2g6-deficiency in Pla2g6M-/- mice led to exaggerat...