The contribution and therapeutic implications of IGHMBP2 mutations on IGHMBP2 biochemical activity and ABT1 association [0.03%]
IGHMBP2突变对生化活性和ABT1关联性的贡献及其治疗意义
Gangadhar P Vadla,Kamal Singh,Christian L Lorson et al.
Gangadhar P Vadla et al.
Mutations within immunoglobulin mu DNA binding protein (IGHMBP2), an RNA-DNA helicase, result in SMA with respiratory distress type I (SMARD1) and Charcot Marie Tooth type 2S (CMT2S). The underlying biochemical mechanism of IGHMBP2 is unkno...
Corrigendum to "Functional characterization of AF-04, an afucosylated anti-MARV GP antibody" [BBA Mol. Basis Dis. 1870 (2024) 166964] [0.03%]
对“AF-04的功能表征，一种抗MARV GP的去岩藻糖基化抗体”[BBA Mol. Basis Dis. 1870 (2024) 166964]的勘误
Min Zhang,Yuting Zhang,Haiyan Wu et al.
Min Zhang et al.
Pyrazole derivative Z10 ameliorates acute pancreatitis by inhibiting the ERK/Ddt pathway [0.03%]
吡唑派生物Z10通过抑制ERK/Ddt通路减轻急性胰腺炎
Wenying Zeng,Jian Pan,Wanlian Li et al.
Wenying Zeng et al.
Acute pancreatitis (AP) can lead to death; however, there is no specific treatment for AP. Screening of drugs for AP treatment is rarely performed. Compounds were screened in a primary pancreatic acinar cell and peritoneal macrophage cocult...
GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease [0.03%]
GDI2的缺失缓解了5xFAD阿尔茨海默病模型小鼠的神经退化和记忆丧失
Meitian Wang,Xiuqing He,Jie Li et al.
Meitian Wang et al.
Accumulation of insoluble deposits of amyloid β-peptide (Aβ), derived from amyloid precursor protein (APP) processing, represents one of the major pathological hallmarks of Alzheimer's disease (AD). Perturbations in APP transport and hydr...
PADI4 negatively regulates RIG-I-mediated antiviral response through deacetylation of IFN-β promoter via HDAC1 [0.03%]
PADI4通过HDAC1去乙酰化IFN-β启动子从而负向调控RIG-I介导的抗病毒反应
Qingwen Feng,Qingwei Guo,Weijie Yu et al.
Qingwen Feng et al.
The production of type I interferon (IFN) is precisely modulated by host to protect against viral infection efficiently without obvious immune disorders. Elucidating the tight control towards type I IFN production would be helpful to get in...
Oleic and linoleic acids promote chondrocyte apoptosis by inhibiting autophagy via downregulation of SIRT1/FOXO1 signaling [0.03%]
油酸和亚油酸通过下调SIRT1/FOXO1信号传导抑制自噬从而促进软骨细胞凋亡
Xiaodong Li,Chen Zhao,Chuanyuan Mao et al.
Xiaodong Li et al.
Osteoarthritis (OA) is a complex joint disease that currently has no cure. OA involves metabolic disorders in chondrocytes and an imbalance between autophagy and apoptosis. As a common risk factor for OA, obesity induces changes in the fatt...
Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease [0.03%]
阿尔茨海默病中围绕淀粉样斑块的营养不良轴突中的中性脂质积聚
Hao Huang,Md Golam Sharoar,Joseph Pathoulas et al.
Hao Huang et al.
Alzheimer's disease (AD) is characterized by the formation β-amyloid (Aβ) deposited neuritic plaques. Recent evidence suggests that abnormal lipid metabolism and accumulation could serve as biomarkers for neurodegenerative diseases, inclu...
Imp7 siRNA nanoparticles protect against mechanical ventilation-associated liver injury by inhibiting HMGB1 production and NETs formation [0.03%]
Imp7 siRNA纳米颗粒通过抑制HMGB1生成和NETS形成来保护机械通气所致的肝损伤
Ning Ding,Hui Xiao,Lixiao Zhen et al.
Ning Ding et al.
Mechanical ventilation (MV) has the potential to induce extra-pulmonary organ damage by adversely affecting the lungs and promoting the secretion of inflammatory cytokines. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory med...
The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2 [0.03%]
肠道微生物代谢物乙酰-L-肉碱通过CADM2改善肠炎症和免疫平衡
Kai Lin,Weiyang Zheng,Mingyue Guo et al.
Kai Lin et al.
Intestinal symbiotic bacteria play a key role in the regulation of immune tolerance in inflammatory bowel disease (IBD) hosts. However, the bacterial strains directly involved in this regulation and their related metabolites are largely unk...
Jia-Horung Hung,Ping-Hsing Tsai,Wilson Jr F Aala et al.
Jia-Horung Hung et al.
Background: Previous studies have confirmed the expression of tissue inhibitor of metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains unknown. ...