CCAT1 attenuates intermittent hypoxia associated endothelial cell pyroptosis through STAU1-mediated IRF1 mRNA degradation [0.03%]
间歇性缺氧相关的内皮细胞焦亡是由STAU1介导的IRF1 mRNA降解所抑制，CCAT1起到相反作用
Wen Liu,Xinxin Li,Qing Zhu et al.
Wen Liu et al.
Background: Previous studies have established that vascular endothelial dysfunction is prevalent among obstructive sleep apnea (OSA) patients. Nonetheless, the mechanism by which intermittent hypoxia (IH) contributes to e...
Oncostatin M promotes versican expression in cardiac fibroblasts to facilitate extracellular matrix remodeling [0.03%]
肿瘤坏死因子M促进心脏成纤维细胞中的血管素表达以促进细胞外基质重塑
Yunxiaoxiao Wu,Ziyu Zeng,Chenying Xiang et al.
Yunxiaoxiao Wu et al.
Myocardial injury is accompanied by an acute inflammatory response. Our previous work identified Oncostatin M as a key cytokine promoting heart regeneration through stimulating cardiomyocyte proliferation, while its effects on fibroblasts c...
HMGA2 inhibits Pink1-mediated mitophagy and promotes vascular calcification [0.03%]
HMGA2抑制Pink1介导的线粒体自噬并促进血管钙化
Shengjue Xiao,Zhengdong Chen,Yiqing Yang et al.
Shengjue Xiao et al.
Mitochondrial dysfunction is implicated in the development of vascular calcification, whereas protective mitophagy helps to hinder its progression. HMGA2 plays a pivotal role in regulating mitochondrial integrity and mitophagy. However, the...
ZFP36L1-mediated PRDM1 mRNA degradation inhibits inflammatory activation of Kupffer cells and ameliorates DCD liver ischemic-reperfusion injury [0.03%]
ZFP36L1介导的PRDM1mRNA降解抑制 kupffer细胞炎症活化并改善dcdb肝缺血再灌注损伤
Peng Du,Meng Deng,Xin Ge et al.
Peng Du et al.
Background: Ischemia-reperfusion injury (IRI) represents a significant and unavoidable clinical challenge in donation after cardiac death (DCD) liver transplantation. Excessive sterile inflammation plays a critical role i...
MAIT cells accumulated via CXCL12-CXCR4 chemotaxis are involved in pathologic gastric inflammation among Helicobacter pylori-infected patients [0.03%]
胃炎患者体内通过CXCL12-CXCR4化学吸引积累的MAIT细胞参与了病理性胃炎的发生发展过程
Fang Zhang,Youjian Zhou,Tingting Xia et al.
Fang Zhang et al.
Background: Helicobacter pylori can cause gastritis, peptic ulcers, and even gastric cancer. In addition to conventional T cells, mucosal-associated invariant T (MAIT) cells may have an important immunologic role in mucos...
Osteopontin aggravates myocardial fibrosis by promoting phenotypic transition of cardiac fibroblasts via Hippo-YAP pathway [0.03%]
骨基质蛋白通过Hippo-YAP信号促进心肌纤维化中的表型转换作用
Chen Liu,Wentao Liu,Yuan Wang et al.
Chen Liu et al.
Osteopontin (OPN), a glycosylated protein ubiquitously in cellular matrix, exhibits a low expression in normal myocardial tissue but a high expression in fibrotic myocardial tissue. However, the action and mechanisms of OPN on the pathogene...
Type 5 diabetes: A comprehensive review to understand the basis of diabetes of poverty [0.03%]
五型糖尿病：全面回顾以了解贫困糖尿病的病因基理
Jalal Taneera,Rania Saeed,Eglal Mahgoub et al.
Jalal Taneera et al.
Malnutrition-Related Diabetes Mellitus (MRDM) is a subtype of diabetes associated with chronic malnutrition, primarily observed in low- and middle-income countries (LMICs) and impoverished populations. The disease is characterized by onset ...
Repair of amyloid-β-induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion [0.03%]
P21活化激酶激活和Rab3a介导的囊泡融合共同修复淀粉样蛋白诱导的细胞膜损伤
Deepak Kunhi Valappil,Priyadarshini Veerabhadraswamy,Prakhyath Hegde et al.
Deepak Kunhi Valappil et al.
The interaction of amyloid-β (Aβ) peptides with the plasma membrane (PM) is a potential trigger that initiates the formation of higher-order aggregates, membrane alterations/damage, and progressive neurotoxicity in Alzheimer's disease (AD...
Integrative analysis of single-cell and bulk transcriptomes reveals metabolic heterogeneity and identifies PFKP as a therapeutic target in cervical cancer [0.03%]
单细胞和批量转录组的综合分析揭示了代谢异质性，并在宫颈癌中将PFKP鉴定为治疗靶点
Yujing Shi,Zhaoyue Zhang,Xiaoke Di et al.
Yujing Shi et al.
Cervical cancer (CC) is still a major gynecological tumor among women globally. The heterogeneity landscape and prognostic value of metabolic reprogramming in CC remain unclear. Our research first uncovered metabolic heterogeneity and ident...
Targeting the NLRP3 inflammasome signalling in acute myeloid leukemia: Mechanisms, therapeutics, and future directions [0.03%]
靶向急性髓系白血病中NLRP3炎性小体信号通路：机制、疗法和未来方向
Sally H Fayad,Alaa Mohamed Salah,Ayad A Jaffa et al.
Sally H Fayad et al.
Acute myeloid leukemia (AML) is one of the most frequent hematological malignancies. It is a complex and aggressive disease of undifferentiated hematopoietic progenitor cells, with high rates of relapse and drug resistance, posing significa...