Development of a TEAD-independent reporter system for specific and sensitive measurement of YAP/TAZ activity [0.03%]
开发一种TEAD独立的报告系统，用于特异性和灵敏地测量YAP/TAZ活性
Jiuge Zhang,Wenqian Yang,Qiuyun Yuan et al.
Jiuge Zhang et al.
Accurate quantification of Yes-associated protein (YAP) and its paralog TAZ is critical for understanding their biological functions, however, existing reporter systems are constrained by their reliance on endogenous TEAD transcription fact...
Insights from Interleukin-6 trans-signaling and implications for the control of cytokine activity [0.03%]
有关白细胞介素-6复 hợp因子信号转导的启示及其对细胞因子活性控制的意义
Stefan Rose-John
Stefan Rose-John
Interleukin-6 is a protein of 184 amino acids and belongs to the four-helical family of cytokines. Interleukin-6 is a major inflammatory mediator and an important target in the treatment of autoimmune diseases. In addition, Interleukin-6 ha...
ATM kinase phosphorylates HSP90 on T297 changing its conformation dynamics and promoting its interaction with HER2 receptor tyrosine kinase [0.03%]
ATM激酶通过T297位点磷酸化HSP90，改变其构象动力学并促使其与HER2受体酪氨酸激酶相互作用
Giulia Fianco,Irene Taddei,Veronica Oropallo et al.
Giulia Fianco et al.
Heat Shock Protein 90 (HSP90) is an essential molecular chaperone whose activity is regulated not only by co-chaperones but also by distinct post-translational modifications. Interestingly, its chaperone activity is essential for the stabil...
USP49 regulates lipid metabolism in hepatocellular carcinoma by stabilizing RACK1 to promote tumor proliferation and migration [0.03%]
USP49通过稳定RACK1来调节肝细胞癌中的脂质代谢以促进肿瘤增殖和迁移
Weikang Xu,Jijun Shan,Jifei Wang et al.
Weikang Xu et al.
Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options. While ubiquitin-specific peptidase 49 (USP49) has been implicated in various cancers, its role in HCC is unclear. Here, we found that USP49 is upre...
FOXA2/ALDOB axis modulation of fatty acid beta-oxidation influences irinotecan resistance in colorectal cancer [0.03%]
FOXA2/ALDOB轴调控脂肪酸β氧化影响结直肠癌.irinotecan耐药性
Yuan Jin,Chao Hu,Dianfu Pang
Yuan Jin
Colorectal cancer (CRC) exhibits altered lipid metabolism associated with therapy resistance. FOXA2, a lipid metabolism activator, mediates fatty acid β-oxidation in CRC, but its role in irinotecan (CPT-11) resistance remains unclear. Thro...
Regulation of E-cadherin by mixed lineage kinase 3 (MLK3) mediates cell adhesion in ovarian cancer spheroids [0.03%]
混合谱系激酶3通过调节E-钙黏着蛋白介导卵巢癌细胞球的细胞粘附
Mariah C J Rozier,Danielle N Adjei,Rachel A Radtke et al.
Mariah C J Rozier et al.
Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that activates MAPK signaling pathways and promotes cell proliferation, migration and invasion. E-cadherin is an essential cel...
ADAR1 upregulates the translation of cytochrome c via the inhibition of translocation into stress granules, facilitating apoptosis by an anticancer agent [0.03%]
ADAR1通过抑制细胞应激颗粒化促进抗癌剂诱导的凋亡
Motoki Isono,Tomoka Yamakawa,Kyoka Nagaoka et al.
Motoki Isono et al.
Adenosine-to-inosine (A-to-I) RNA editing catalyzed by adenosine deaminase acting on RNA (ADAR) 1 is the most abundant RNA modification in humans. We noticed that there are multiple A-to-I RNA editing sites in the 3'-UTR of cytochrome c (CY...
Understanding complex formation of gp130 cytokines for the design of selective therapeutics [0.03%]
调控gp130细胞因子复合物形成以设计选择性药物治疗方案
Isabel Ramón Roth,Jana I Fuehring,Christoph Garbers
Isabel Ramón Roth
Cytokines activate their target cells via binding to specific receptors on the cell surface. The receptor glycoprotein 130 (gp130) is ubiquitously expressed throughout the human body and used by nine members of the interleukin-6 (IL-6) fami...
Loss of Sugen Kinase 495 in macrophages alleviates chronic colitis by improving mitochondrial stress [0.03%]
巨噬细胞中Sugen激酶495的丧失通过改善线粒体应激来缓解慢性结肠炎
Jikai He,Yuanmei Lou,Pingan Yao et al.
Jikai He et al.
Inflammatory bowel disease (IBD), highlighted by chronic intestinal inflammation, is an escalating global health concern. The pathogenesis of IBD is not fully understood, with DSS-induced chronic colitis in mice serving as a prevalent model...
Prevotella copri leads to colonic barrier dysfunction via the succinate receptor 1-FoxM1-IL-6 axis [0.03%]
琥珀酸受体1-FoxM1-IL-6轴介导的普氏菌导致结肠屏障功能障碍
Rui Li,Shuang Liu,Haiyan Zhang et al.
Rui Li et al.
Prevotella copri, a key commensal bacterium in the human gut microbiome, exhibits both positive and negative abundance correlations with various disorders. Although multiple studies have suggested an association between P. copri and intesti...